Hydroxyproline dehydrogenase

BE0020644ProteinHumansPRODH2

Dehydrogenase that converts trans-4-L-hydroxyproline to delta-1-pyrroline-3-hydroxy-5-carboxylate (Hyp) using ubiquinone-10 as the terminal electron acceptor. It is acted on by 1 drug in DrugBank.

Gene name
PRODH2
UniProtKB entry
Q9UF12Swiss-Prot
Residues / weight
460 residues · 50,897 Da
Also known as
1.5.5.3 · HSPOX1 · HYPDH · Kidney and liver proline oxidase 1 · Probable proline dehydrogenase 2

Resolves to

Protein
UniProtQ9UF12UniProt nameHYPDH_HUMAN
Gene
HGNCHGNC:17325NCBI Gene58510GeneCardsPRODH2
Pharmacology
KEGGhsa:58510
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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6+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Hydroxyproline dehydrogenase, how selective are they, and which programs against it are still in active trials?

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