Neurogenic locus notch homolog protein 3

BE0021069ProteinHumansNOTCH3

Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination (PubMed:15350543, PubMed:14714274). It is acted on by 2 drugs in DrugBank.

Gene name
NOTCH3
UniProtKB entry
Q9UM47Swiss-Prot
Cellular location
Cell membrane
Residues / weight
2,321 residues · 243,629 Da
Also known as
Notch 3

Resolves to

Protein
UniProtQ9UM47UniProt nameNOTC3_HUMAN
Gene
HGNCHGNC:7883NCBI Gene4854GeneCardsNOTCH3
Pharmacology
IUPHAR/GtoPdb2860KEGGhsa:4854
Structure
PDB4ZLPPDB5CZVPDB5CZX
Drugs

What you can answer from here — as of September 03, 2024

2DrugsApproved to experimental, with action, bond type and pharmacological action
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8Pfam domainsDomain architecture mapped to Pfam families and clans
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6+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Neurogenic locus notch homolog protein 3, and which indications are they being tested in?

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