Short transient receptor potential channel 5
Details
- Name
- Short transient receptor potential channel 5
- Kind
- protein
- Synonyms
- hTRP-5
- hTRP5
- Transient receptor protein 5
- TRP-5
- TRP5
- TrpC5
- Gene Name
- TRPC5
- UniProtKB Entry
- Q9UL62Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0013477|Short transient receptor potential channel 5 MAQLYYKKVNYSPYRDRIPLQIVRAETELSAEEKAFLNAVEKGDYATVKQALQEAEIYYN VNINCMDPLGRSALLIAIENENLEIMELLLNHSVYVGDALLYAIRKEVVGAVELLLSYRR PSGEKQVPTLMMDTQFSEFTPDITPIMLAAHTNNYEIIKLLVQKRVTIPRPHQIRCNCVE CVSSSEVDSLRHSRSRLNIYKALASPSLIALSSEDPILTAFRLGWELKELSKVENEFKAE YEELSQQCKLFAKDLLDQARSSRELEIILNHRDDHSEELDPQKYHDLAKLKVAIKYHQKE FVAQPNCQQLLATLWYDGFPGWRRKHWVVKLLTCMTIGFLFPMLSIAYLISPRSNLGLFI KKPFIKFICHTASYLTFLFMLLLASQHIVRTDLHVQGPPPTVVEWMILPWVLGFIWGEIK EMWDGGFTEYIHDWWNLMDFAMNSLYLATISLKIVAYVKYNGSRPREEWEMWHPTLIAEA LFAISNILSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYF YYETRAIDEPNNCKGIRCEKQNNAFSTLFETLQSLFWSVFGLLNLYVTNVKARHEFTEFV GATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFDEGGTLPPP FNIIPSPKSFLYLGNWFNNTFCPKRDPDGRRRRRNLRSFTERNADSLIQNQHYQEVIRNL VKRYVAAMIRNSKTHEGLTEENFKELKQDISSFRYEVLDLLGNRKHPRSFSTSSTELSQR DDNNDGSGGARAKSKSVSFNLGCKKKTCHGPPLIRTMPRSSGAQGKSKAESSSKRSFMGP SLKKLGLLFSKFNGHMSEPSSEPMYTISDGIVQQHCMWQDIRYSQMEKGKAEACSQSEIN LSEVELGEVQGAAQSSECPLACSSSLHCASSICSSNSKLLDSSEDVFETWGEACDLLMHK WGDGQEEQVTTRL
- Number of residues
- 973
- Molecular Weight
- 111411.03
- Theoretical pI
- Not Available
- GO Classification
- Not Available
- General Function
- Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective (By similarity). May also be activated by intracellular calcium store depletion. Mediates calcium-dependent phosphatidylserine externalization and apoptosis in neurons via its association with PLSCR1 (By similarity)
- Specific Function
- actin binding
- Pfam Domain Function
- Signal Regions
- Not Available
- Transmembrane Regions
- 331-351 399-419 438-458 471-491 513-533 604-624
- Cellular Location
- Cell membrane
- Gene sequence
- Not Available
- Chromosome Location
- X
- Locus
- Xq23
- External Identifiers
Resource Link UniProtKB ID Q9UL62 UniProtKB Entry Name TRPC5_HUMAN GeneCard ID TRPC5 HGNC ID HGNC:12337 PDB ID(s) 6YSN, 7D4P, 7D4Q, 7E4T, 7WDB, 7X6C, 7X6I, 8GVW, 8GVX KEGG ID hsa:7224 IUPHAR/Guide To Pharmacology ID 490 NCBI Gene ID 7224 - General References
- Not Available