Zerencotrep

DB21710ExperimentalSmall molecule

Zerencotrep is a small molecule drug. The usage of the INN stem '-cotrep' in the name indicates that Zerencotrep is a transient receptor potential canonical channel 5 (TRPC5) antagonist. Zerencotrep... Zerencotrep has a monoisotopic molecular weight of 524.11 Da.

Mechanism: Pharmacologically active on Short transient receptor potential channel 1, Short transient receptor potential channel 4, and Short transient receptor potential channel 5
Curator reviewed
Formula / weight: C₂₃H₂₀ClF₃N₄O₅ · 524.88 g/mol (avg)
Code names: HC-608 · Pico145

Resolves to

Compound

UNIIHMIMSYLCWQCAS1628287-16-0ChEMBLCHEMBL4466522ChEBI757686PubChem85473438

Structure

InChIKeyPRJHEJGMSOBHTO-UHFFFAOYSA-NSMILESCN1C2=C(N(CC3=CC=C(Cl)C=C3)C(OC3=CC(OC(F)(F)F)=CC=C3)=N2)C(=O)N(CCCO)C1=O

Targets

P48995TRPC1Q9UBN4TRPC4Q9UL62TRPC5

What you can answer from here — as of September 23, 2026

3Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

9+ReferencesStructured and connected to the statements they support

Which drugs share a target with Zerencotrep, and which of those have an active Phase 3 trial?

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