1-phosphatidylinositol 3-phosphate 5-kinase

BE0021269ProteinHumansPIKFYVE

Dual specificity kinase implicated in myriad essential cellular processes such as maintenance of endomembrane homeostasis, and endocytic-vacuolar pathway, lysosomal trafficking, nuclear transport, stress- or hormone-induced signaling and cell cycle progression (PubMed:23086417). It is acted on by 1 drug in DrugBank.

Gene name
PIKFYVE
UniProtKB entry
Q9Y2I7Swiss-Prot
Cellular location
Endosome membrane
Residues / weight
2,098 residues · 237,134 Da
Also known as
2.7.1.150 · FYVE finger-containing phosphoinositide kinase · KIAA0981 · Phosphatidylinositol 3-phosphate 5-kinase · Phosphatidylinositol 3-phosphate 5-kinase type III

Resolves to

Protein
UniProtQ9Y2I7UniProt nameFYV1_HUMAN
Gene
HGNCHGNC:23785NCBI Gene200576GeneCardsPIKFYVE
Pharmacology
IUPHAR/GtoPdb2857KEGGhsa:200576
Structure
PDB7K2V
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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37GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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5+ReferencesStructured and connected to the statements they support
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Which compounds in development act on 1-phosphatidylinositol 3-phosphate 5-kinase, and which indications are they being tested in?

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