Apilimod

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Apilimod
Accession Number
DB05611
Description
Not Available
Type
Small Molecule
Groups
Investigational
Structure
Thumb
Weight
Average: 418.501
Monoisotopic: 418.211724101
Chemical Formula
C23H26N6O2
Synonyms
  • Apilimod
External IDs
  • STA 5326
  • STA-5326

Pharmacology

Pharmacology
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Indication

Investigated for use/treatment in crohn's disease and psoriasis and psoriatic disorders.

Contraindications & Blackbox Warnings
Contraindications
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Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half-life
Not Available
Clearance
Not Available
Adverse Effects
Medicalerrors
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Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Products

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Product Ingredients
IngredientUNIICASInChI Key
Apilimod mesylate5G3P5OK11S870087-36-8GAJWNIKZLYZYSY-OKUPSQOASA-N

Categories

Drug Categories
Classification
Not classified

Chemical Identifiers

UNII
GFW2K84S4L
CAS number
541550-19-0
InChI Key
HSKAZIJJKRAJAV-KOEQRZSOSA-N
InChI
InChI=1S/C23H26N6O2/c1-18-5-4-6-19(15-18)17-25-28-21-16-22(29-10-13-30-14-11-29)27-23(26-21)31-12-8-20-7-2-3-9-24-20/h2-7,9,15-17H,8,10-14H2,1H3,(H,26,27,28)/b25-17+
IUPAC Name
4-{6-[(E)-2-[(3-methylphenyl)methylidene]hydrazin-1-yl]-2-[2-(pyridin-2-yl)ethoxy]pyrimidin-4-yl}morpholine
SMILES
CC1=CC=CC(\C=N\NC2=CC(=NC(OCCC3=CC=CC=N3)=N2)N2CCOCC2)=C1

References

General References
Not Available
ChemSpider
8348782
ChEMBL
CHEMBL4297643
ZINC
ZINC000011726230
Wikipedia
Apilimod

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
2CompletedNot AvailableCrohn's Disease (CD)1
2CompletedTreatmentActive, Moderate to Severe Rheumatoid Arthritis1
2CompletedTreatmentCrohn's Disease (CD)2
2RecruitingTreatmentCoronavirus Disease 2019 (COVID‑19) / COVID-19 Disease1
1Active Not RecruitingTreatmentLymphoma, Non-Hodgkin; Leukemia, Chronic Lymphocytic1
1CompletedTreatmentCommon Variable Immunodeficiency1
1, 2CompletedTreatmentCrohn's Disease (CD)1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0278 mg/mLALOGPS
logP3.91ALOGPS
logP4.82ChemAxon
logS-4.2ALOGPS
pKa (Strongest Acidic)14.42ChemAxon
pKa (Strongest Basic)5.89ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count8ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area84.76 Å2ChemAxon
Rotatable Bond Count8ChemAxon
Refractivity123.26 m3·mol-1ChemAxon
Polarizability45.92 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Drug created on November 18, 2007 18:26 / Updated on February 21, 2021 18:51