Lysyl oxidase homolog 2

BE0021305ProteinHumansLOXL2

Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine) (PubMed:27735137). It is acted on by 4 drugs in DrugBank.

Gene name
LOXL2
UniProtKB entry
Q9Y4K0Swiss-Prot
Cellular location
Secreted, extracellular space, extracellular matrix, basement membrane
Residues / weight
774 residues · 86,724 Da
Also known as
1.4.3.13 · Lysyl oxidase-like protein 2 · Lysyl oxidase-related protein 2 · Lysyl oxidase-related protein WS9-14

Resolves to

Protein
UniProtQ9Y4K0UniProt nameLOXL2_HUMAN
Gene
HGNCHGNC:6666NCBI Gene4017GeneCardsLOXL2
Pharmacology
IUPHAR/GtoPdb2853KEGGhsa:4017
Structure
PDB5ZE3
Drugs

What you can answer from here — as of September 03, 2024

4DrugsApproved to experimental, with action, bond type and pharmacological action
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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9+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Lysyl oxidase homolog 2, and which indications are they being tested in?

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