Simtuzumab

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Simtuzumab
DrugBank Accession Number
DB12152
Background

Simtuzumab has been used in trials studying the treatment and basic science of Myelofibrosis, Pancreatic Cancer, Colorectal Cancer, and Idiopathic Pulmonary Fibrosis.

Type
Biotech
Groups
Investigational
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Protein Chemical Formula
Not Available
Protein Average Weight
Not Available
Sequences
Not Available
Synonyms
  • GS-6624
  • Simtuzumab

Pharmacology

Indication

Not Available

Pharmacology
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Contraindications & Blackbox Warnings
Contraindications
Contraindications & Blackbox Warnings
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Our Blackbox Warnings cover Risks, Contraindications, and Adverse Effects
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AbciximabThe risk or severity of adverse effects can be increased when Abciximab is combined with Simtuzumab.
AdalimumabThe risk or severity of adverse effects can be increased when Adalimumab is combined with Simtuzumab.
AlemtuzumabThe risk or severity of adverse effects can be increased when Alemtuzumab is combined with Simtuzumab.
AlirocumabThe risk or severity of adverse effects can be increased when Alirocumab is combined with Simtuzumab.
AnsuvimabThe risk or severity of adverse effects can be increased when Simtuzumab is combined with Ansuvimab.
Anthrax immune globulin humanThe risk or severity of adverse effects can be increased when Anthrax immune globulin human is combined with Simtuzumab.
Antilymphocyte immunoglobulin (horse)The risk or severity of adverse effects can be increased when Antilymphocyte immunoglobulin (horse) is combined with Simtuzumab.
Antithymocyte immunoglobulin (rabbit)The risk or severity of adverse effects can be increased when Antithymocyte immunoglobulin (rabbit) is combined with Simtuzumab.
Asfotase alfaThe risk or severity of adverse effects can be increased when Asfotase alfa is combined with Simtuzumab.
AtezolizumabThe risk or severity of adverse effects can be increased when Atezolizumab is combined with Simtuzumab.
Interactions
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Food Interactions
Not Available

Categories

Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
Not Available
Kingdom
Organic Compounds
Super Class
Organic Acids
Class
Carboxylic Acids and Derivatives
Sub Class
Amino Acids, Peptides, and Analogues
Direct Parent
Peptides
Alternative Parents
Not Available
Substituents
Not Available
Molecular Framework
Not Available
External Descriptors
Not Available
Affected organisms
Not Available

Chemical Identifiers

UNII
11Z5AIU653
CAS number
1318075-13-6

References

General References
Not Available
PubChem Substance
347911289
Wikipedia
Simtuzumab

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
2CompletedPreventionPrimary Sclerosing Cholangitis (PSC)1
2CompletedTreatmentAgnogenic Myeloid Metaplasia1
2CompletedTreatmentFibrosis, Liver1
2CompletedTreatmentFibrosis, Liver / Hepatitis C Infection With HIV Co-Infection / Hepatitis C Viral Infection / Human Immunodeficiency Virus (HIV) Infections1
2CompletedTreatmentMalignant Neoplasm of Pancreas1
2CompletedTreatmentNon-Alcoholic Steatohepatitis (NASH)1
2TerminatedTreatmentColorectal Cancers1
2TerminatedTreatmentIdiopathic Pulmonary Fibrosis (IPF)2
2TerminatedTreatmentLiver Fibrosis Due to NASH2
1CompletedBasic ScienceIdiopathic Pulmonary Fibrosis (IPF)1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available

Drug created on October 20, 2016 21:29 / Updated on February 21, 2021 18:53