Beta-secretase 2

BE0021401ProteinHumansBACE2

Responsible for the proteolytic processing of the amyloid precursor protein (APP). It is acted on by 1 drug in DrugBank.

Gene name
BACE2
UniProtKB entry
Q9Y5Z0Swiss-Prot
Cellular location
Cell membrane
Residues / weight
518 residues · 56,180 Da
Also known as
3.4.23.45 · AEPLC · ALP56 · Asp 1 · ASP1

Resolves to

Protein
UniProtQ9Y5Z0UniProt nameBACE2_HUMAN
Gene
HGNCHGNC:934NCBI Gene25825GeneCardsBACE2
Pharmacology
IUPHAR/GtoPdb2331KEGGhsa:25825
Structure
PDB2EWYPDB3ZKGPDB3ZKI
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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17GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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2+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Beta-secretase 2, and which indications are they being tested in?

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