Gap junction delta-2 protein

BE0023585ProteinHumansGJD2

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. It is acted on by 1 drug in DrugBank.

Gene name
GJD2
UniProtKB entry
Q9UKL4Swiss-Prot
Cellular location
Cell membrane
Residues / weight
321 residues · 36,092 Da
Also known as
Connexin-36 · Cx36 · Gap junction alpha-9 protein · GJA9

Resolves to

Protein
UniProtQ9UKL4UniProt nameCXD2_HUMAN
Gene
HGNCHGNC:19154NCBI Gene57369GeneCardsGJD2
Pharmacology
KEGGhsa:57369
Structure
PDB2N6APDB7XKIPDB7XKK
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which approved drugs act on Gap junction delta-2 protein, how selective are they, and which programs against it are still in active trials?

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