Alkaline phosphatase, tissue-nonspecific isozyme

BE0027704ProteinMouseAlpl

Alkaline phosphatase that metabolizes various phosphate compounds and plays a key role in skeletal mineralization and adaptive thermogenesis (PubMed:10620060, PubMed:11028439, PubMed:14982838, PubMed:23942722, PubMed:33981039). It is acted on by 1 drug in DrugBank.

Gene name
Alpl
UniProtKB entry
P09242Swiss-Prot
Cellular location
Cell membrane
Residues / weight
524 residues · 57,514 Da
Also known as
3.1.3.1 · Akp-2 · Akp2 · Alkaline phosphatase 2 · Alkaline phosphatase liver/bone/kidney isozyme

Resolves to

Protein
UniProtP09242UniProt namePPBT_MOUSE
Gene
NCBI Gene11647
Pharmacology
KEGGmmu:11647
Drugs

What you can answer from here — as of December 18, 2025

1DrugApproved to experimental, with action, bond type and pharmacological action
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35GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which compounds in development act on Alkaline phosphatase, tissue-nonspecific isozyme, and which indications are they being tested in?

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