DNA replication helicase

BE0028602ProteinHHV-1HELI

Component of the helicase/primase complex. It is acted on by 1 drug in DrugBank.

Gene name
HELI
UniProtKB entry
P10189Swiss-Prot
Cellular location
Host nucleus
Residues / weight
882 residues · 98,715 Da
Also known as
3.6.4.-

Resolves to

Protein
UniProtP10189UniProt nameHELI_HHV11
Gene
NCBI Gene2703420
Pharmacology
KEGGvg:2703420
Structure
PDB9NDTPDB9NE0PDB9NEE
Drugs

What you can answer from here — as of October 16, 2026

1DrugApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which approved drugs act on DNA replication helicase, how selective are they, and which programs against it are still in active trials?

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