NAV

Pritelivir

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Pritelivir
DrugBank Accession Number
DB11844
Background

Pritelivir has been used in trials studying the prevention of HSV-2 and Genital Herpes.

Type
Small Molecule
Groups
Investigational
Structure
3D
Similar Structures
Weight
Average: 402.49
Monoisotopic: 402.082032804
Chemical Formula
C18H18N4O3S2
Synonyms
  • Pritelivir
External IDs
  • AIC-316
  • AIC316
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Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
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interactions in your software
Adenovirus type 7 vaccine liveThe therapeutic efficacy of Adenovirus type 7 vaccine live can be decreased when used in combination with Pritelivir.
Anthrax vaccineThe therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Pritelivir.
Bacillus calmette-guerin substrain connaught live antigenThe therapeutic efficacy of Bacillus calmette-guerin substrain connaught live antigen can be decreased when used in combination with Pritelivir.
Bacillus calmette-guerin substrain russian BCG-I live antigenThe therapeutic efficacy of Bacillus calmette-guerin substrain russian BCG-I live antigen can be decreased when used in combination with Pritelivir.
Bacillus calmette-guerin substrain tice live antigenThe therapeutic efficacy of Bacillus calmette-guerin substrain tice live antigen can be decreased when used in combination with Pritelivir.
Food Interactions
Not Available

Categories

Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as phenylpyridines. These are polycyclic aromatic compounds containing a benzene ring linked to a pyridine ring through a CC or CN bond.
Kingdom
Organic compounds
Super Class
Organoheterocyclic compounds
Class
Pyridines and derivatives
Sub Class
Phenylpyridines
Direct Parent
Phenylpyridines
Alternative Parents
Phenylacetamides / 2,4,5-trisubstituted thiazoles / Organosulfonamides / Tertiary carboxylic acid amides / Heteroaromatic compounds / Aminosulfonyl compounds / Azacyclic compounds / Organopnictogen compounds / Organonitrogen compounds / Organic oxides
show 2 more
Substituents
2,4,5-trisubstituted 1,3-thiazole / 2-phenylpyridine / Aminosulfonyl compound / Aromatic heteromonocyclic compound / Azacycle / Azole / Benzenoid / Carbonyl group / Carboxamide group / Carboxylic acid derivative
show 17 more
Molecular Framework
Aromatic heteromonocyclic compounds
External Descriptors
Not Available
Affected organisms
Not Available

Chemical Identifiers

UNII
07HQ1TJ4JE
CAS number
348086-71-5
InChI Key
IVZKZONQVYTCKC-UHFFFAOYSA-N
InChI
InChI=1S/C18H18N4O3S2/c1-12-17(27(19,24)25)26-18(21-12)22(2)16(23)11-13-6-8-14(9-7-13)15-5-3-4-10-20-15/h3-10H,11H2,1-2H3,(H2,19,24,25)
IUPAC Name
N-methyl-N-(4-methyl-5-sulfamoyl-1,3-thiazol-2-yl)-2-[4-(pyridin-2-yl)phenyl]acetamide
SMILES
CN(C(=O)CC1=CC=C(C=C1)C1=CC=CC=N1)C1=NC(C)=C(S1)S(N)(=O)=O

References

General References
Not Available
PubChem Compound
491941
PubChem Substance
347828188
ChemSpider
430613
BindingDB
50237366
ChEMBL
CHEMBL4069597
ZINC
ZINC000003955689
Wikipedia
Pritelivir

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
3RecruitingTreatmentHerpes Simplex Infections1
2CompletedPreventionHSV-2 / HSV-2 Infection1
2CompletedTreatmentHerpes Labialis1
2TerminatedPreventionGenital Herpes1
1CompletedOtherHerpes Simplex Infections1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0115 mg/mLALOGPS
logP2.37ALOGPS
logP1.97Chemaxon
logS-4.5ALOGPS
pKa (Strongest Acidic)8.58Chemaxon
pKa (Strongest Basic)4.42Chemaxon
Physiological Charge0Chemaxon
Hydrogen Acceptor Count5Chemaxon
Hydrogen Donor Count1Chemaxon
Polar Surface Area106.25 Å2Chemaxon
Rotatable Bond Count5Chemaxon
Refractivity101.96 m3·mol-1Chemaxon
Polarizability41.27 Å3Chemaxon
Number of Rings3Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-0pb9-0090500000-4e918e226f82f34b6031
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-0pdi-0491400000-8f1e957b87dc9ec6467e
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-0udi-0010900000-378ceed90c78f0eef585
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-004i-9010000000-2867667bd98beb24c63d
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-016r-0920000000-13d5332d52f774e465bf
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-004i-9601000000-f3e01f756d2c834baf5e
Predicted 1H NMR Spectrum1D NMRNot Applicable
Predicted 13C NMR Spectrum1D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
AdductCCS Value (Å2)Source typeSource
[M-H]-210.8699913
predicted
DarkChem Lite v0.1.0
[M-H]-185.10674
predicted
DeepCCS 1.0 (2019)
[M+H]+211.5638913
predicted
DarkChem Lite v0.1.0
[M+H]+187.46474
predicted
DeepCCS 1.0 (2019)
[M+Na]+210.6746913
predicted
DarkChem Lite v0.1.0
[M+Na]+193.9013
predicted
DeepCCS 1.0 (2019)

Drug created at October 20, 2016 20:53 / Updated at February 21, 2021 18:53