- Accession Number
Biological catalysts and their cofactors.
Drug Drug Description Asparaginase Escherichia coli An asparaginase enzyme from E. coli used as part of treatment regimens for acute lymphoblastic leukemias. Asparaginase Erwinia chrysanthemi An asparagine-specific enzyme used as part of a chemotherapeutic regimen to treat patients with acute lymphoblastic leukemia and lymphoblastic lymphoma. Pegaspargase A modified form of L-asparagine amidohydrolase used to treat acute lymphoblastic leukemia, which is dependent on an external source of asparagine. Calaspargase pegol An asparagine specific enzyme used to treat acute lymphoblastic leukemia. Ribaxamase Ribaxamase is under investigation in clinical trial NCT02563106 (A Study of SYN-004 for the Prevention of c.diff in Patients With a LRTI). Red blood cell-encapsulated L-asparaginase Red blood cell-encapsulated L-asparaginase is Asparaginase Escherichia coli encapsulated inside donor-derived red blood cells, which target cancer cells capable of altering asparagine and glutamine metabolism. It is being investigated in...
- Drugs & Drug Targets
Drug Target Type Asparaginase Escherichia coli L-asparagine target Asparaginase Escherichia coli Thyroxine-binding globulin carrier Pegaspargase L-asparagine target Pegaspargase Thyroxine-binding globulin carrier Calaspargase pegol L-asparagine target