Growth Hormone

Name
Growth Hormone
Accession Number
DBCAT000145
Description

Growth hormone (somatotropin) can be synthesized with methods of recombinant DNA technology. Since action of GH is highly species-specific, recombinant growth hormones of several species (including humans, cows, and pigs) have been developed. They have been used to stimulate growth.

Drugs
DrugDrug Description
SomatotropinA recombinant human growth hormone used as replacement therapy in various conditions of growth failure, growth hormone deficiency, and weakness in children and adults.
SomatremA recombinant growth hormone used to treat adult growth hormone deficiency and treat disrupted growth in children due to growth hormone insufficiency or deficiency, turner's syndrome, chronic renal failure, and small stature for gestational age.
SomapacitanA human growth hormone analog subcutaneous injection indicated for adults with growth hormone deficiency.
Somatropin pegolSomatropin pegol is under investigation in clinical trial NCT00715689 (Dose Study in Growth Hormone Deficient Adults Investigating Safety, Pharmacokinetics and Pharmacodynamics of NNC126-0083).
AlbusomatropinAlbusomatropin has been used in trials studying the treatment of Growth Hormone-Deficiency and Growth Hormone Deficiency.
SomatrogonA long-acting recombinant human growth hormone used as the long-term treatment of pediatric patients who have growth failure due to growth hormone deficiency.
LonapegsomatropinA human growth hormone indicated in the treatment of growth failure due to inadequate endogenous growth hormone secretion.
Eftansomatropin alfaEftansomatropin alfa (GX-H9) comprises a recombinant human growth hormone fused to hyFc, a synthetic hybrid Fc fragment. It is under investigation for the treatment of growth hormone deficiency.
Drugs & Drug Targets
DrugTargetType
SomatotropinGrowth hormone receptortarget
SomatotropinProlactin receptortarget
SomatotropinCytochrome P450 1A2enzyme
SomatotropinCytochrome P450 2C19enzyme
SomatotropinP-glycoprotein 1transporter
SomatremGrowth hormone receptortarget
SomatremInsulin-like growth factor 1 receptortarget
SomapacitanCorticosteroid 11-beta-dehydrogenase isozyme 1enzyme
SomapacitanCytochrome P450 2C12, female-specificenzyme
SomapacitanCytochrome P450 1A2enzyme
SomapacitanCytochrome P450 2C19enzyme
SomapacitanSerum albumincarrier
SomapacitanGrowth hormone receptortarget
SomatrogonGrowth hormone receptortarget
LonapegsomatropinCorticosteroid 11-beta-dehydrogenase isozyme 1enzyme
LonapegsomatropinGrowth hormone receptortarget
LonapegsomatropinProlactin receptortarget
LonapegsomatropinCytochrome P450 1A2enzyme
LonapegsomatropinCytochrome P450 2C19enzyme
LonapegsomatropinP-glycoprotein 1transporter