Antiplatelet agents
- Name
- Antiplatelet agents
- Accession Number
- DBCAT000149
- Description
Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.
- Drugs
Drug Drug Description 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine Not Available Abciximab A monoclonal anti-glycoprotein IIb/IIIa receptor antibody used to prevent thrombosis during percutaneous coronary intervention. Acetylsalicylic acid A salicylate used to treat pain, fever, inflammation, migraines, and reducing the risk of major adverse cardiovascular events. Ajoene Not Annotated Aloxistatin Not Annotated Anagrelide A platelet-reducing agent used to treat thrombocythemia, and its related complications, secondary to myeloproliferative neoplasms. Andrographolide Investigated for use/treatment in ulcerative colitis. Apafant Apafant is a small molecule drug. The usage of the INN stem '-pafant' in the name indicates that Apafant is a platelet-activating factor antagonist. Apafant has a monoisotopic molecular weight... Ataprost Ataprost is a small molecule drug. Ataprost has a monoisotopic molecular weight of 348.23 Da. Beraprost For the treatment of pulmonary hypertension. Bisindolylmaleimide VIII Not Available Buflomedil Not Annotated Butylphthalide Butylphthalide has been used in trials studying the prevention of Restenosis. Cangrelor A P2Y12 platelet receptor antagonist used during percutaneous coronary intervention to reduce the risk for periprocedural myocardial infarction (MI), repeat coronary revascularization, and stent thrombosis (ST). Caplacizumab A von Willebrand factor (vWF)-directed antibody fragment used to treat acquired thrombotic thrombocytopenic purpura (aTTP). Cilostamide Cilostamide is a small molecule drug. Cilostamide has a monoisotopic molecular weight of 342.19 Da. Cilostazol An antiplatelet agent and vasodilator used for the symptomatic relief of intermittent claudication. Clopidogrel An antiplatelet agent used to prevent blood clots in peripheral vascular disease, coronary artery disease, and cerebrovascular disease. Cloricromen Not Annotated Daltroban Daltroban is a small molecule drug. Daltroban has a monoisotopic molecular weight of 353.05 Da. Dazmegrel Dazmegrel is a small molecule drug. Dazmegrel has a monoisotopic molecular weight of 283.13 Da. Defibrotide A mixture of single-stranded oligonucleotides used in the treatment of severe hepatic veno-occlusive disease with renal or pulmonary dysfunction following hematopoietic stem-cell transplantation. Dipyridamole A phosphodiesterase inhibitor used to prevent postoperative thromboembolic events. Efegatran Efegatran is a small molecule drug. Efegatran has a monoisotopic molecular weight of 416.25 Da. Emoxypine Emoxypine is under investigation in clinical trial NCT06221826 (MEXIDOL® in the Rehabilitation Treatment of Patients With Acute Cerebral Failure). Enfenamic acid Enfenamic acid is a small molecule drug. Enfenamic acid has a monoisotopic molecular weight of 241.11 Da. Epoprostenol A vasodilator and platelet aggregation inhibitor used for the management of primary pulmonary hypertension and pulmonary hypertension in patients with heart failure. Eptifibatide A peptide-based antagonist for glycoprotein IIb/IIIa used in the medical management of myocardial infarction and as an adjunct to percutaneous coronary intervention. Foropafant Foropafant is a small molecule drug. The usage of the INN stem '-pafant' in the name indicates that Foropafant is a platelet-activating factor antagonist. Foropafant has a monoisotopic molecular weight... Hydroxytyrosol Hydroxytyrosol has been used in trials studying the prevention of Breast Cancer. Ibudilast For the treatment of multiple sclerosis, asthma, and cerebrovascular disease. Icosapent ethyl An ethyl ester of eicosapentaenoic acid (EPA) that reduces synthesis and enhances clearance of triglycerides that is used to treat patients with severe hypertriglyceridemia. Ifetroban Ifetroban has been used in trials studying the treatment of Skin Diseases, Autoimmune Diseases, Pathologic Processes, Scleroderma, Limited, and Scleroderma, Diffuse, among others. Iloprost A synthetic prostacyclin analog used to treat pulmonary arterial hypertension (PAH) and frostbites. Indobufen A reversible platelet aggregation inhibitor used to prevent coronary and peripheral artery occlusion. Ketanserin Ketanserin has been investigated for the treatment of Septic Shock, Severe Sepsis, and Diabetic Foot Ulcer. Lamifiban Lamifiban is a small molecule drug. The usage of the INN stem '-fiban' in the name indicates that Lamifiban is a fibrinogen receptor antagonist (glycoprotein IIb/IIIa receptor antagonist). Lamifiban has... Ligustrazine Ligustrazine is under investigation in clinical trial NCT05942352 (Clinical Study of Ligustrazine in Treating Alcohol Addiction). Linsidomine Not Annotated Maritime pine extract A plant extract in nutritional supplements for healthy hair, skin, and nails. Naftopidil Naftopidil has been investigated for the treatment of Disorder of Urinary Stent. Nimesulide A cyclooxygenase 2 inhibitor used to treat acute pain and primary dysmenorrhea. Nitroaspirin Nitroaspirin has been investigated for the treatment of Intermittent Claudication. Pentoxifylline A methylxanthine derivative used to treat intermittent claudication caused by chronic occlusive arterial disease of the limbs. Picotamide A platelet aggregation inhibitor indicated in the treatment of myocardial infarction, thrombosis, cerebrovascular disorders, pulmonary emboli, and atherosclerosis. Piroximone Piroximone is a small molecule drug. Piroximone has a monoisotopic molecular weight of 217.09 Da. Plafibride Plafibride is a small molecule drug. Plafibride has a monoisotopic molecular weight of 355.13 Da. Prasugrel A P2Y12 platelet inhibitor used to reduce risk of thrombotic cardiovascular events in unstable angina or non-ST-elevation myocardial infarction (NSTEMI), and in patients with STEMI when managed with either primary or delayed PCI. Ramatroban Ramatroban has been used in trials studying the treatment of Asthma. Relcovaptan Not Annotated Resveratrol Being investigated for the treatment of Herpes labialis infections (cold sores). Ridogrel Used as an adjunctive therapy to induce thrombolysis in patients suffering acute myocardial infarction. Rosmarinic acid Not Annotated S-Nitrosoglutathione Not Annotated Sarpogrelate Sarpogrelate has been investigated for the treatment of Diabetes Mellitus, Diabetic Nephropathy, Coronary Artery Disease, and Renal Insufficiency, Chronic. Satigrel Satigrel is a small molecule drug. Satigrel has a monoisotopic molecular weight of 337.13 Da. Sibrafiban Sibrafiban is a small molecule drug. The usage of the INN stem '-fiban' in the name indicates that Sibrafiban is a fibrinogen receptor antagonist (glycoprotein IIb/IIIa receptor antagonist). Sibrafiban has... SKF-96365 free base SKF-96365 is a receptor-mediated calcium entry (RMCE) inhibitor structurally different from other calcium antagonists. Sulfinpyrazone A platelet inhibitory and uricosuric agent used to inhibit thrombotic and embolic processes and to manage the chronic phases of gout . Sulotroban Sulotroban is a small molecule drug. Sulotroban has a monoisotopic molecular weight of 335.08 Da. Tesmilifene Intended for the treatment of various forms of cancer. Ticagrelor A P2Y12 platelet inhibitor used in patients with a history of myocardial infarction or with acute coronary syndrome (ACS) to prevent future myocardial infarction, stroke and cardiovascular death. Ticlopidine A platelet aggregation inhibitor used in the prevention of conditions associated with thrombi, such as stroke and transient ischemic attacks (TIA). Tirofiban A platelet aggregation inhibitor used to prevent thrombotic events in non-ST elevated acute coronary syndrome. Tranilast For the treatment of bronchial asthma, keloid and hypertrophic scar, and allergic disorders such as asthma, allergic rhinitis and atopic dermatitis. Trapidil Used in the treatment of chronic stable angina . Triflusal A medication related to acetylsalicylic acid with antithrombotic effects used in the treatment of thromboembolic diseases. Vapiprost Vapiprost is a small molecule drug. Vapiprost has a monoisotopic molecular weight of 477.29 Da. Vicagrel Vicagrel is under investigation in clinical trial NCT03599284 (The Efficacy, Safety and Pharmacokinetic of Antiplatelet Therapy for Vicagrel). Vorapaxar A platelet aggregation inhibitor used to reduce thrombotic cardiovascular events in patients with a history of myocardial infarction (MI) or peripheral arterial disease (PAD). Xemilofiban Xemilofiban is a small molecule drug. The usage of the INN stem '-fiban' in the name indicates that Xemilofiban is a fibrinogen receptor antagonist (glycoprotein IIb/IIIa receptor antagonist). Xemilofiban has... - Drugs & Drug Targets