This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Buflomedil
- DrugBank Accession Number
- DB13510
- Background
Not Available
- Type
- Small Molecule
- Groups
- Experimental
- Structure
Structure for Buflomedil (DB13510)
- Weight
- Average: 307.39
Monoisotopic: 307.178358289 - Chemical Formula
- C17H25NO4
- Synonyms
- Buflomedil
Pharmacology
- Indication
Not Available
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Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareAbciximab The risk or severity of bleeding can be increased when Buflomedil is combined with Abciximab. Abrocitinib The risk or severity of bleeding and thrombocytopenia can be increased when Buflomedil is combined with Abrocitinib. Acebutolol Buflomedil may decrease the antihypertensive activities of Acebutolol. Aceclofenac The risk or severity of bleeding can be increased when Aceclofenac is combined with Buflomedil. Acemetacin The risk or severity of bleeding can be increased when Acemetacin is combined with Buflomedil. - Food Interactions
- Not Available
Products
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Categories
- ATC Codes
- C04AX20 — Buflomedil
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as alkyl-phenylketones. These are aromatic compounds containing a ketone substituted by one alkyl group, and a phenyl group.
- Kingdom
- Organic compounds
- Super Class
- Organic oxygen compounds
- Class
- Organooxygen compounds
- Sub Class
- Carbonyl compounds
- Direct Parent
- Alkyl-phenylketones
- Alternative Parents
- Phenylbutylamines / Butyrophenones / Phenoxy compounds / Methoxybenzenes / Benzoyl derivatives / Aryl alkyl ketones / Anisoles / Alkyl aryl ethers / N-alkylpyrrolidines / Gamma-amino ketones show 5 more
- Substituents
- Alkyl aryl ether / Alkyl-phenylketone / Amine / Anisole / Aromatic heteromonocyclic compound / Aryl alkyl ketone / Azacycle / Benzenoid / Benzoyl / Butyrophenone show 17 more
- Molecular Framework
- Aromatic heteromonocyclic compounds
- External Descriptors
- Not Available
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- V7I71DQ432
- CAS number
- 55837-25-7
- InChI Key
- OWYLAEYXIQKAOL-UHFFFAOYSA-N
- InChI
- InChI=1S/C17H25NO4/c1-20-13-11-15(21-2)17(16(12-13)22-3)14(19)7-6-10-18-8-4-5-9-18/h11-12H,4-10H2,1-3H3
- IUPAC Name
- 4-(pyrrolidin-1-yl)-1-(2,4,6-trimethoxyphenyl)butan-1-one
- SMILES
- COC1=CC(OC)=C(C(=O)CCCN2CCCC2)C(OC)=C1
References
- General References
- Not Available
- External Links
- ChemSpider
- 2373
- BindingDB
- 50170664
- 19836
- ChEBI
- 94538
- ChEMBL
- CHEMBL188921
- ZINC
- ZINC000000005191
- Wikipedia
- Buflomedil
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Pill Capsule Injection, solution Solution Oral Solution / drops Oral Tablet Tablet, coated Tablet, extended release - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.486 mg/mL ALOGPS logP 2.33 ALOGPS logP 1.88 Chemaxon logS -2.8 ALOGPS pKa (Strongest Acidic) 15.61 Chemaxon pKa (Strongest Basic) 8.69 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 5 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 48 Å2 Chemaxon Rotatable Bond Count 8 Chemaxon Refractivity 86.27 m3·mol-1 Chemaxon Polarizability 34.46 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 195.6510473 predictedDarkChem Lite v0.1.0 [M-H]- 173.64964 predictedDeepCCS 1.0 (2019) [M+H]+ 196.7119473 predictedDarkChem Lite v0.1.0 [M+H]+ 176.00766 predictedDeepCCS 1.0 (2019) [M+Na]+ 195.8176473 predictedDarkChem Lite v0.1.0 [M+Na]+ 182.10092 predictedDeepCCS 1.0 (2019)
Drug created at June 23, 2017 20:43 / Updated at February 21, 2021 18:54