- Accession Number
A group of compounds derived from ammonia by substituting organic radicals for the hydrogens. (From Grant & Hackh's Chemical Dictionary, 5th ed)
Drug Drug Description Indium In-111 satumomab pendetide For diagnosis of extrahepatic malignant cancers Choline A nutrient found in a wide variety of vitamins including pre-natal formulations. Spermine For nutritional supplementation, also for treating dietary shortage or imbalance Fluvoxamine A selective serotonin-reuptake inhibitor used to treat obsessive-compulsive disorder. Amphetamine A CNS stimulant and sympathomimetic agent indicated for the treatment of Attention Deficit Hyperactivity Disorder (ADHD). Esmolol A cardioselective beta-adrenergic blocker used for the short-term control of ventricular rate and heart rate in various types of tachycardia, including perioperative tachycardia and hypertension. Carbidopa A dopa decarboxylase inhibitor used in combination with levodopa for the symptomatic treatment of idiopathic Parkinson disease and other conditions associated with parkinsonian symptoms. Phentermine A sympathomimetic anorectic agent used as a short-term adjunct therapy that is included in a regimen of weight reduction in cases of exogenous obesity. Tramadol A centrally-acting opioid agonist and SNRI (serotonin/norepinephrine reuptake inhibitor) used for the management of moderate to severe pain in adults. Betaxolol A cardioselective beta blocking agent commonly used to treat hypertension and elevated intraocular pressure (when administered ophthalmically). Succinylcholine A depolarizing skeletal muscle relaxant used adjunctly to anesthesia and for skeletal muscle relaxation during intubation, mechanical ventilation, and surgical procedures. Dofetilide A class III antiarrhythmic drug used for the maintenance of normal sinus rhythm and cardioversion in cases of atrial fibrillation and atrial flutter. Midodrine An alpha-adrenergic agonist used to treat orthostatic hypotension. Citalopram A selective serotonin reuptake inhibitor (SSRI) used in the treatment of depression. Eletriptan A triptan used for the treatment of migraines. Oxyphenonium For the treatment of visceral spasms Isoetharine For the treatment of asthma, wheezing, and chronic asthmatic bronchitis. Gadodiamide A gadolinium-based contrast agent used for the visualization of lesions with vascularity during magnetic resonance imaging (MRI) scans. Milrinone A PDE-III inhibitor with inotropic, lusitropic, and vasodilatory properties used for the short-term treatment of acute decompensated heart failure. Sulfanilamide A sulfonamide anti-infective used to treat vulvovaginal candidiasis caused by Candida albicans. Sulfisoxazole A sulfonamide antibiotic used with other antibiotics to prevent and treat a variety of bacterial infections. Metoprolol A beta-blocker used in the treatment of hypertension and angina, and used to reduce mortality due to myocardial infarction. Crotamiton A topical scabicidal and antipruritic agent used for scabies eradication and for the relief of pruritus. Venlafaxine A selective serotonin and norepinephrine reuptake inhibitor (SNRI) used for the treatment of major depression. Atomoxetine A selective norepinephrine reuptake inhibitor (SNRI) used in the management of Attention Deficit Hyperactivity Disorder (ADHD). Zolmitriptan A member of the triptan class of 5-HT(1B/1D/1F) receptor agonist drugs used for the acute treatment of migraine with or without aura in adults. Ethambutol An antituberculosis agent used in the prophylaxis and treatment of tuberculosis (TB). Atenolol A synthetic beta-1 selective blocker used in the management of hypertension and chronic angina, and to reduce mortality in known or suspected myocardial infarction in hemodynamically stable patients. Sulfadiazine A sulfonamide antibiotic used in a variety of infections, such as urinary tract infections, trachoma, and chancroid. Sapropterin A cofactor used as an adjunct to phenylalanine restriction in the treatment of phenylketonuria (PKU). Norepinephrine A sympathomimetic used in the control of blood pressure during various hypotensive states and as an adjunct treatment during cardiac arrest. Timolol A non-selective beta adrenergic blocker used in the treatment of elevated intraocular pressure in ocular hypertension or open angle glaucoma. Colestipol A bile acid sequestrant used as an adjunct to diet and exercise to reduce LDL-C cholesterol levels in patients with primary hypercholesterolemia. Mexiletine A class 1B antiarrhythmic agent used in the treatment of documented ventricular arrhythmias that warrant treatment. Phenylephrine An alpha-1 adrenergic agonist used in the management of hypotension, generally in the surgical setting associated with the use of anesthetics. Phenylpropanolamine A sympathomimetic that was previously used in nasal decongestants and weight loss products, but has been withdrawn by the FDA due to safety risks and lack of efficacy. Gentian violet cation An antiseptic violet dye used to prevent various infections, including fungal and bacterial infections. Carbamoylcholine A direct acting miotic agent administered ophthalmically to decrease intraocular pressure after cataract surgery, and to induce miosis during surgery. Metocurine iodide For use as an anesthesia adjunct to induce skeletal muscle relaxation and to reduce the intensity of muscle contractions in convulsive therapy. Dipivefrin A prodrug of epinephrine used in ophthalmic solutions to reduce intraocular pressure in chronic open-angle glaucoma. Fluoxetine A selective serotonin reuptake inhibitor used to treat major depressive disorder, bulimia, OCD, premenstrual dysphoric disorder, panic disorder, and bipolar I. Hexylcaine Used as a local anesthetic for surface application, infiltration or nerve block Gallamine triethiodide A nondepolarizing nerve blocker used in addition to anesthesia to cause skeletal muscle relaxation. Sotalol A methane sulfonanilide beta adrenergic antagonist used to treat life-threatening ventricular arrhythmias and to maintain sinus rhythm in atrial fibrillation or flutter. Tridihexethyl Used as an adjunct in the treatment of peptic ulcer disease and in Acquired nystagmus Carteolol A beta adrenergic antagonist used to treat arrhythmia, angina, hypertension, and glaucoma. Acetohydroxamic acid A synthetic urea derivative used to treat urea splitting bacterial infections of the urinary tract. Propranolol A non-selective beta adrenergic antagonist used to treat hypertension, angina, atrial fibrillation, myocardial infarction, migraine, essential tremor, hypertrophic subaortic stenosis, and pheochromocytoma. Fenfluramine Fenfluramine is a phenethylamine that is structurally similar to serotonin. Due to its ability to increase extracellular serotonin levels, modulate serotonergic and other neurologic receptors, and control neurotransmission, it is effective in treating pharmacoresistant seizures. Sulfamethizole A sulfonamide antibiotic used to treat a wide variety of susceptible bacterial infections. Levocarnitine A quaternary ammonium compound used to treat carnitine deficiency or to stimulate gastric and pancreatic secretions in hyperlipoproteinemia. Labetalol An alpha and beta adrenergic antagonist used to treat hypertension, angina, and sympathetic overactivity syndrome. Metaraminol For the treatment and prevention of hypotension due to hemorrhage, spinal anesthesia, and shock associated with brain damage Bisoprolol A beta-1 adrenergic blocking agent used to prevent myocardial infarction and heart failure and to treat mild to moderate hypertension. Sulfacetamide A corticosteroid used to treat inflammatory ocular conditions and acne vulgaris. Sevelamer A phosphate binder used to treat hyperphosphatemia. Verapamil A non-dihydropyridine calcium channel blocker used in the treatment of angina, arrhythmia, and hypertension. Sulfametopyrazine An antibiotic used in the treatment or prevention of bacterial infections and malaria. Epinephrine A hormone and neurotransmitter used to treat allergic reactions, to restore cardiac rhythm, and to control mucosal congestion, glaucoma, and asthma. Sumatriptan A serotonin receptor agonist used to treat migraines and cluster headaches. Furosemide A loop diuretic used to treat hypertension and edema in congestive heart failure, liver cirrhosis, renal disease, and hypertension. Methoxamine An alpha adrenergic agonist used to treat hypotension. Pralidoxime A cholinesterase reactivator used to treat organophosphate poisoning. Naftifine An antifungal agent used to treat infections of the Tinea, Trichophyton, and Epidermophyton species. Deferoxamine A chelating agent used to treat iron or aluminum toxicity and some blood transfusion dependent anemias. Tranylcypromine A monoamine oxidase inhibitor used to treat major depressive disorder. Propantheline An antimuscarinic agent used to treat urinary incontinence, hyperhidrosis, as well as cramps and spasms of the stomach, intestines, and bladder. Mefenamic acid An NSAID used to treat mild to moderate pain for no more than a week, and primary dysmenorrhea. Marimastat For the treatment of various cancers Gadopentetic acid A gadolinium compound used as a contrast agent in MRIs. Tripelennamine A histamine H1 antagonist used to treat hypersensitivity reactions, coughs, and the common cold. Orciprenaline A beta-2 adrenergic agonist used to treat bronchospasm, asthma, and COPD. Dobutamine A beta-1 agonist used to treat cardiac decompensation in patients with organic heart disease or from cardiac surgery. Cysteamine A cystine depleting agent used to treat the effects of cystinosis. Pseudoephedrine An alpha and beta adrenergic agonist used to treat nasal and sinus congestion, as well as allergic rhinitis. Benzphetamine A sympathomimetic used to manage exogenous obesity short term. Alprenolol For the treatment of hypertension, angina, and arrhythmia Ritodrine An adrenergic beta agonist used to treat premature labor. Benzonatate A non-narcotic oral antitussive drug used to suppress coughing. Terbutaline A beta-2 adrenergic agonist used as a bronchodilator and to prevent premature labor. Sulfapyridine A sulfonamide antibiotic used to treat dermatitis herpetiformis, benign mucous membrane pemphigoid and pyoderma gangrenosum. Bitolterol Used to dilate air passages in the lungs that have become narrowed as a result of disease or inflammation. It is used in the treatment of asthma and chronic obstructive... Almotriptan A 5-HT1B/1D receptor agonist used to treat migraines. Phenoxybenzamine An alpha adrenergic antagonist used to treat pheochromocytoma and episodes of hypertension and sweating. Colesevelam A bile acid sequestrant used to lower LDL-C in adults with hyperlipidemia and pediatric patients with heterozygous familial hypercholesterolemia, and to improve glycemic control in type 2 diabetes. Diethylpropion An appetite suppressant used for the short term treatment of exogenous obesity in addition to calorie restriction. Salmeterol A long-acting beta-2 adrenergic receptor agonist used to treat asthma and COPD. Meclofenamic acid An NSAID used to treat mild to moderate pain, primary dysmenorrhea, heavy menstrual blood loss, rheumatoid arthritis, and osteoarthritis. Methantheline For the treatment of peptic ulcer disease, irritable bowel syndrome, pancreatitis, gastritis, biliary dyskinesia, pylorosplasm, and reflex neurogenic bladder in children. Hexafluronium Used as an adjunct with succinylcholine (or suxamethonium chloride) to prolong muscle relaxation and to prevent succinylcholine-induced muscle fasciculations. Demecarium For the topical treatment of chronic open-angle glaucoma. Naratriptan A 5-HT1B/1D receptor agonist used to treat migraines. Rizatriptan A 5-HT1B/1D receptor agonist used to treat migraines. Pindolol A beta adrenoceptor antagonist used to treat hypertension, edema, ventricular tachycardias, and atrial fibrillation. Methyldopa A centrally-acting alpha-2 adrenergic agonist used to manage hypertension alone or in combination with hydrochlorothiazide, and to treat hypertensive crises. Edetic acid A chelating agent used to treat mercury and lead toxicity and some blood transfusion dependent anemias. Formoterol An inhaled long-acting beta2-adrenergic receptor agonist used as a bronchodilator in the management of asthma and COPD. Dimenhydrinate A medication used to prevent and treat nausea, vomiting, vertigo, and motion sickness. Glycopyrronium An anticholinergic agent used to treat hyperhidrosis, severe drooling, COPD, used with other medications to treat ulcers, and used in anesthesia. Dopamine A catecholamine neurotransmitter used to treat hemodynamic imbalances, poor perfusion of vital organs, low cardiac output, and hypotension. Frovatriptan A 5-HT1B/1D receptor agonist used to treat migraines. Salbutamol A beta-2 adrenergic receptor agonist used to treat asthma, bronchitis, COPD, as well as prevent exercise induced bronchospasms. Edrophonium A cholinesterase inhibitor used to diagnose and evaluate myasthenia gravis. Sulfamethoxazole An oral sulfonamide antibiotic, given in combination with trimethoprim, used to treat a variety of infections of the urinary tract, respiratory system, and gastrointestinal tract. Bethanechol A muscarinic agonist used to treat postoperative and postpartum nonobstructive functional urinary retention and neurogenic atony of the bladder with retention. Amlexanox Used as a paste in the mouth to treat aphthous ulcers (canker sores). Tolterodine A muscarinic receptor antagonist used to treat overactive bladder with urinary incontinence, urgency, and frequency. Selegiline A monoamine oxidase inhibitor used to treat major depressive disorder and Parkinson's. Isoprenaline A catecholamine non-selective beta-adrenergic agonist typically used to treat bradycardia and heart block. Melatonin An endogenous hormone produced by the pineal gland that regulates sleep-wake cycles and when provided exogenously has beneficial effects on sleep-onset latency; available as an over-the-counter supplement. Promethazine A first-generation antihistamine used for the treatment of allergic conditions, nausea and vomiting, and motion sickness. Diphenhydramine A H1 receptor antihistamine used in the treatment of seasonal allergies, and various allergic reactions including sneezing, runny nose, itchy/watery eyes, itching of nose or throat, pruritus, urticaria, insect bites/stings, and allergic rashes. Butenafine A topical antifungal used to treat tinea versicolor, tinea pedis, tinea cruris, and tinea corporis. Arbutamine Used to elicit acute cardiovascular responses (cardiac stumulant), similar to those produced by exercise, in order to aid in diagnosing the presence or absence of coronary artery disease (CAD) in... Sertraline A selective serotonin reuptake inhibitor (SSRI) indicated to treat major depressive disorder, social anxiety disorder and many other psychiatric conditions. Ambenonium A cholinesterase inhibitor that targets both muscarinic and nicotinic receptors indicated for the treatment of myasthenia gravis. Carvedilol A non selective beta-adrenergic antagonist used to treat mild to severe chronic heart failure, hypertension, and left ventricular dysfunction following myocardial infarction in clinically stable patients. Bretylium A norepinephrine release inhibitor used for the prophylaxis and therapy of ventricular fibrillation, as well as the treatment of life-threatening ventricular arrhythmias. Orphenadrine A muscarinic antagonist used as an adjunct for the symptomatic relief of musculoskeletal pain and discomfort. Escitalopram A selective serotonin re-uptake inhibitor used in the treatment of major depressive disorder (MDD), generalized anxiety disorder (GAD), and other select psychiatric disorders such as obsessive-compulsive disorder (OCD). Dexfenfluramine For the management of obesity including weight loss and maintenance of weight loss in patients on a reduced calorie diet Acebutolol A selective β1-receptor antagonist used for the management of hypertension and ventricular premature beats in adults. Tubocurarine Tubocurarine is a non-depolarizing neuromuscular blocking agent and the first identified curare alkaloid. Curare is one of the names used to describe plant-derived poisons used by indigenous South Americans to... Nadolol A non-selective beta-adrenergic antagonist used for the management of arrhythmias, angina pectoris, and hypertension. Levobunolol A beta-adrenergic antagonist used for the reduction of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma. Metipranolol A beta-adrenergic antagonist used for the reduction of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma. Aminophylline A bronchodilator consisting of theophylline that is used for the treatment of bronchospasm due to asthma, emphysema and chronic bronchitis. Levodopa A dopamine precursor used in the management of Parkinson's disease, often in combination with carbidopa, as well as other conditions associated with parkinsonism. Bromodiphenhydramine For management of symptoms related to hay fever and other types of allergy and used to help bring up phlegm, thin secretions, and make a cough productive. Decamethonium For use as a skeletal muscle relaxant Lisdexamfetamine A central nervous system (CNS) stimulant used to treat attention deficit hyperactivity disorder (ADHD) and moderate to severe eating disorders. Arformoterol A beta-2 adrenergic agonist and bronchodilator used for long term, symptomatic treatment of reversible bronchoconstriction in patients with chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema. Fenoterol A beta-2 adrenergic agonist and bronchodilator used for the symptomatic treatment of asthma. Pirbuterol A beta-2 adrenergic agonist and bronchodilator used for the symptomatic treatment of asthma. Bevantolol For the treatment of angina pectoris and hypertension. Practolol Used in the emergency treatment of cardiac arrhythmias. Sulfacytine Used orally in the treatment of acute urinary tract infections. Sulfadoxine A long acting sulfonamide used for the treatment or prevention of malaria. Oxtriphylline A bronchodilator used for the treatment of asthma, bronchitis, COPD, and emphysema. Metocurine Metocurine is a muscle relaxant. Penbutolol A beta-adrenergic antagonist used for the management of mild to moderate arterial hypertension, alone or in combination with other antihypertensive agents. Ephedrine An alpha and beta-adrenergic agonist indicated to treat hypotension under anesthesia, allergic conditions, bronchial asthma, and nasal congestion. Mephentermine A sympathomimetic agent used in the treatment of hypotension. Procaterol A beta-2 adrenergic receptor agonist and bronchodilator used for the treatment of asthma and chronic obstructive pulmonary disease (COPD). Neostigmine A cholinesterase inhibitor used in the symptomatic treatment of myasthenia gravis by improving muscle tone. Choline magnesium trisalicylate Choline magnesium trisalicylate is used to reduce pain and inflammation caused by conditions such as arthritis. This medication is also used to treat fever in adults. Clenbuterol A decongestant and bronchodilator used in a variety of respiratory conditions. Bambuterol A long acting beta2-adrenoceptor agonist for the management of lung diseases associated with bronchospasm. Amrinone A positive inotropic agent and phosphodiesterase inhibitor used in the management of treatment of congestive heart failure. Phenazopyridine A local anesthetic used for the symptomatic relief of pain, burning, urgency, frequency, and general discomfort caused by lower urinary tract irritations that are a result of infection, trauma, surgery, endoscopic procedures, or the passage of equipment or catheters. 5-Methoxy-N,N-diisopropyltryptamine 5-methoxy-N,N-diisopropyltryptamine (5-MeO-DIPT) is a tryptamine derivative and shares many similarities with schedule I tryptamine hallucinogens such as alpha-ethyltryptamine, N,N-dimethyltryptamine, N,N-diethyltryptamine, bufotenine, psilocybin and psilocin. Since 1999, there has been a... MMDA MMDA is a recreational drug. It has no current medical uses and is a Schedule I controlled substance in the USA at present. Bufotenine A hallucinogenic serotonin analog found in frog or toad skins, mushrooms, higher plants, and mammals, especially in the brains, plasma, and urine of schizophrenics. Bufotenin has been used as a... Indopan Indopan (alpha-methyltryptamine) is a stimulant and psychoactive drug which produces effects similar to 3,4-methylenedioxy-N-methylamphetamine (MDMA), despite being structurally dissimilar. It was developed in the 1960's by Upjohn with the intention... Midomafetamine Clinical trials are now testing the therapeutic potential of MDMA for post-traumatic stress disorder (PTSD) and anxiety associated with terminal cancer. MDMA is one of the four most widely used... 2,5-Dimethoxyamphetamine Not Available 2,5-Dimethoxy-4-ethylamphetamine Not Available 4-Methoxyamphetamine Not Available Fenethylline Not Available 4-Bromo-2,5-dimethoxyamphetamine Not Available Cathine Used to decrease appetite. Embutramide Not Available Dimethyltryptamine Some people use this compound as a psychedelic inducing agent. 1-Phenylcyclohexylamine Not Available Tenamfetamine An amphetamine derivative that inhibits uptake of catecholamine neurotransmitters. It is a hallucinogen. It is less toxic than its methylated derivative but in sufficient doses may still destroy serotonergic neurons... 4-Bromo-2,5-dimethoxyphenethylamine Not Available Etryptamine Developed in the 1960's for use as an antidepressant before market withdrawal in 1962. Fenproporex Fenproporex is used as an appetite suppressant, and anti-obesity agent ; however, due to substance abuse potential, it is an illicit substance in many countries. In some countries, such as... Chlorphentermine Used as an appetite suppressant. Dextroamphetamine A sympathomimetic agent used in the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy. Metamfetamine A sympathomimetic agent used in the treatment of attention deficit hyperactivity disorder (ADHD) and exogenous obesity. Oxprenolol A non-selective beta-adrenergic antagonist used to treat hypertension, angina pectoris, arrhythmias, and anxiety. Sulfamerazine An antibacterial agent used in the treatment of various bacterial infections, such as bronchitis, prostatitis, and urinary tract infections. Sulfamethazine An antibacterial agent used in the treatment of various bacterial infections, such as bronchitis, prostatitis, and urinary tract infections. Alverine A smooth muscle relaxant used to relieve abdominal pain associated with gastrointestinal conditions like heartburn, flatulence, and Irritable Bowel Syndrome. Isopropamide A long-acting anticholinergic drug used to relieve symptoms of spastic and painful symptoms of gastrointestinal conditions and symptoms of flu, colds, and related conditions. Pargyline For the treatment of moderate to severe hypertension. SC-74020 Not Available Roflumilast A selective phosphodiesterase 4 inhibitor indicated to decrease the risk of exacerbations in patients with severe chronic obstructive pulmonary disease (COPD) associated with a history of exacerbations and chronic bronchitis. Cetrimonium A compound that can be used as a topical antiseptic. 2-Aminophenol Not Available Phosphorylcolamine Not Available Coprogen Not Available Methylamine Not Available Putrescine Putrescine is a toxic diamine formed by putrefaction from the decarboxylation of arginine and ornithine. Putrescine is a solid. This compound belongs to the polyamines. These are compounds containing more... Benzhydroxamic Acid Not Available Indirubin-3'-monoxime Not Available WAY-151693 Not Available Aminooxyacetic acid A compound that inhibits aminobutyrate aminotransferase activity in vivo, thereby raising the level of gamma-aminobutyric acid in tissues. [PubChem] Platelet Activating Factor Not Available Flufenamic acid An analgesic drug used to relieve pain associated with rheumatoid diseases. 2-Fluoroaniline Not Available Benzylamine Not Available Ghavamiol Not Available Vorinostat A histone deacetylase (HDAC) inhibitor used for the treatment of cutaneous manifestations in patients with progressive, persistent, or recurrent cutaneous T- cell lymphoma (CTCL) following prior systemic therapies. N-Dodecyl-N,N-Dimethyl-3-Ammonio-1-Propanesulfonate Not Available Filaminast Filaminast is a phosphodiesterase 4 inhibitor (PDE4 inhibitor). As such, has potential in the treatment of asthma and chronic obstructive pulmonary disease (COPD). 3,4-dimethylaniline Not Available Acetylcholine A parasympathomimetic neurotransmitter used to induce miosis of the iris in seconds after delivery of the lens in cataract surgery, in penetrating keratoplasty, iridectomy and other anterior segment surgery where rapid miosis may be required. 4,5-Dimethyl-1,2-phenylenediamine Not Available Sphingosine An amino alcohol with a long unsaturated hydrocarbon chain. Sphingosine and its derivative sphinganine are the major bases of the sphingolipids in mammals. (Dorland, 28th ed) 3,5-Difluoroaniline Not Available Hexamethylene diamine Not Available Glutathionylspermidine Not Available Gallichrome Not Available Trypanothione Not Available Spermidine Spermidine is a polyamine formed from putrescine. It is found in almost all tissues in association with nucleic acids. It is found as a cation at all pH values, and... Butylamine Butylamine is a colourless liquid which acquires a yellow colour upon storage in air. It is one of the four isomeric amines of butane. It is known to have the... Xylarohydroxamate Not Available Histidinol Not Available Malachite Green Not Available N,N,N-Trimethyl-2-(phosphonooxy)ethanaminium Calcium and magnesium salts used therapeutically in hepatobiliary dysfunction. Ethanolamine A viscous, hygroscopic amino alcohol with an ammoniacal odor. It is widely distributed in biological tissue and is a component of lecithin. It is used as a surfactant, fluorimetric reagent,... Butyrylthiocholine A sulfur-containing analog of butyrylcholine which is hydrolyzed by butyrylcholinesterase to butyrate and thiocholine. It is used as a reagent in the determination of butyrylcholinesterase activity. [PubChem] 4-Phenylbutylamine Not Available Phenethylamine Not Available Octamethylenediamine Not Available 6-hydroxydopa quinone Not Available Bb-3497 Not Available 3-Phenylpropylamine Not Available 4-Phospho-D-erythronohydroxamic acid Not Available Niflumic acid A cyclooxygenase-2 inhibitor used to alleviate inflammation, pain, and edema associated with acute and chronic inflammatory conditions, such as rheumatoid arthritis, osteoarthritis, post-operative inflammatory conditions, and physical trauma. N-acetylhistamine Not Available Methapyrilene Methapyrilene, formerly marketed in many drug products, was shown to be a potent carcinogen. Manufacturers voluntarily withdrew methapyriline drug products from the market in May and June 1979. Prenylamine Prenylamine was withdrawn from the Canadian, US, and UK markets in 1988 due to concerns regarding cardiac arrhythmias. Clofedanol An antitussive used for the symptomatic relief of acute cough caused by minor throat and bronchial irritation. Celiprolol A beta-blocker for the management of hypertension and angina pectoris. Brasofensine For the treatment of Parkinson's Disease. Nebivolol A beta blocking agent used to treat hypertension and aid in the management of heart failure. Dapoxetine A selective serotonin reuptake inhibitor used in the treatment of premature ejaculation. Ximelagatran For the treatment of acute deep vein thrombosis. Ezogabine An antiepileptic agent used as an adjuvant treatment of partial-onset seizures. Belinostat A histone deacetylase (HDAC) inhibitor used for the treatment of patients with relapsed or refractory peripheral T-cell lymphoma (PTCL). Arimoclomol Investigated for use/treatment in amyotrophic lateral sclerosis (ALS), diabetes mellitus type 2, neurologic disorders, and neuropathy (diabetic). SQ-109 Investigated for use/treatment in bacterial infection, infectious and parasitic disease (unspecified), and tuberculosis. REP8839 For the treatment of bacterial infections caused by susceptible microorganisms (Staphylococcus aureus, including methicillin-resistant S. aureus (MRSA), and Streptococcus pyogenes). Silver sulfadiazine A topical sulfonamide antibiotic that acts on the bacterial cell wall and cell membrane; approved for the treatment of burns. Histamine An ingredient of topical drugs for the relief of joint pain or muscle aches and pains. C31G Investigated for use/treatment in contraception, HIV infection, and prevention of stdis. AZD 3355 Investigated for use/treatment in gastroesophageal reflux disease (GERD). OPC-28326 Investigated for use/treatment in peripheral vascular disease and raynaud's disease. Pelitinib Investigated for use/treatment in colorectal cancer and lung cancer. CGC-11047 Investigated for use/treatment in lymphoma (unspecified), macular degeneration, prostate cancer, and solid tumors. Alethine Investigated for use/treatment in blood (blood forming organ disorders, unspecified), lymphoma (unspecified), and multiple myeloma. DP-b99 Investigated for use/treatment in strokes and traumatic brain injuries. Sulfathiazole Sulfathiazole is effective against a wide range of gram positive and gram negative pathogenic microorganisms. Although no longer used in humans, it is used in cattle. Sulfadimethoxine For use in the treatment of infections. Nylidrin A vasodilator used to treat patients with peripheral vascular disorders, and elderly patients with symptoms associated with organic mental disorders. Solabegron Investigated for use/treatment in diabetes mellitus type 2, irritable bowel syndrome (IBS), and urinary incontinence. Droxidopa A medication used to treat symptomatic neurogenic orthostatic hypotension (nOH) caused by dopamine beta-hydroxylase deficiency, non-diabetic autonomic neuropathy and primary autonomic failure caused by conditions such as Parkinson's disease. LX-2931 Investigated for use/treatment in rheumatoid arthritis, inflammatory disorders (unspecified), and autoimmune diseases. Refametinib Investigated for use/treatment in cancer/tumors (unspecified). Darapladib Investigated for use/treatment in atherosclerosis. Methoxyamine Investigated for use/treatment in cancer/tumors (unspecified). Trodusquemine Investigated for use/treatment in obesity and diabetes mellitus type 2. Tucidinostat Investigated for use/treatment in cancer/tumors (unspecified). Diethylnorspermine Investigated for use/treatment in renal cell carcinoma, pancreatic cancer, melanoma, and lung cancer. Etilevodopa Investigated for use/treatment in parkinson's disease. Panobinostat A non-selective histone deacetylase inhibitor used to treat multiple myeloma in combination with other antineoplastic agents. Bosutinib An antineoplastic agent used for the treatment of chronic, accelerated, or blast phase Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML) in adults with inadequate clinical response to other treatments. Flupirtine Investigated for use/treatment in fibromyalgia. Dalfampridine A potassium channel blocker used for the improvement of motor function in patients with multiple sclerosis (MS). Perifosine Investigated for use/treatment in solid tumors, multiple myeloma, leukemia (unspecified), lung cancer, and brain cancer. Safinamide A MAO-B inhibitor used as an add-on treatment to levodopa/carbidopa for Parkinson's disease during "off" episodes. Asoprisnil Investigated for use/treatment in uterine fibroids. Mepyramine An antihistamine agent used for the symptomatic treatment of allergy, hypersensitivity reactions, and pruritic skin disorders. Isometheptene A sympathomimetic used to relieve painful spasms in combination with other agents such as caffeine and metamizole. Levonordefrin A topical sympathomimetic amine found in local anesthetic products that is used for nasal decongestion or vasoconstriction during dental procedures. Methacholine A parasympathomimetic bronchoconstrictor used to diagnose bronchial hyperreactivity in subjects who do not have clinically apparent asthma. Norelgestromin A progestin used for the prevention of pregnancy in women who elect to use a transdermal patch as a method of contraception. Propylhexedrine It is used to provide temporary symptomatic relief of nasal congestion due to colds, allergies and allergic rhinitis. Bufuralol Bufuralol is a new, non-selective -adrenoceptor blocking agent. Aniline Aniline, phenylamine or aminobenzene is an organic compound with the formula C6H5NH2. Consisting of an amine attached to a benzene ring, aniline is the prototypical aromatic amine. Being a precursor... Sulfaphenazole For the treatment bacterial infections. Ambroxol A medication indicated for airway secretion clearance therapy. Betaine A methyl group donor used for the treatment of homocystinuria to decrease elevated homocysteine blood levels. Mangafodipir An organ-specific paramagnetic contrast agent indicated for the imaging of the hepatobiliary system and detecting lesions in the liver and pancreas. Methenamine A urinary tract antiseptic and antibacterial drug used for the prophylaxis and treatment of frequently recurring urinary tract infections requiring a long-term therapy. Methylnaltrexone A μ-opioid antagonist used for the treatment of opioid-induced constipation in palliative patients that are inadequately responding to laxative therapy. Protokylol Protokylol is a β-adrenergic receptor agonist used as a bronchodilator in Europe and the United States. Sulfameter Long acting sulfonamide used in leprosy, urinary, and respiratory tract infections. Triethylenetetramine A copper chelating agent used for the management of Wilson's disease in cases where penicillamine therapy is clinically inappropriate. Efaproxiral Not Available Sulfamoxole For the treatment of bacterial infection. Chloropyramine For the treatment of allergic conjunctivitis, allergic rhinitis, bronchial asthma, and other atopic (allergic) conditions. Bopindolol For the management of hypertension, edema, ventricular tachycardias, and atrial fibrillation. Bupranolol Used to manage hypertension and tachycardia. Also used to treat glaucoma. Ivacaftor A cystic fibrosis transmembrane conductance regulator (CFTR) potentiator used alone or in combination products to treat cystic fibrosis in patients who have specific genetic mutations that are responsive to the medication. Tetraethylammonium Tetraethylammonium is an experimental drug with no approved indication. Serotonin For temporary relief of nervousness, anxiety, mood swings, joint pains, weakness, drowsiness, itching and lethargy. Not evaluated by the FDA, homeopathic product. Tyramine Tyramine (4-hydroxyphenethylamine; para-tyramine, mydrial or uteramin) is a naturally occurring monoamine compound and trace amine derived from the amino acid tyrosine. Tyramine acts by inducing the release of catecholamine. An... Acetylcarnitine An acetylated form of the amino acid derivative L-carnitine that assists in mitochondrial fatty acid metabolism. It is under investigation as a treatment for numerous conditions, including neuropathy, depression, and dementia. Fingolimod A sphingosine 1-phosphate receptor modulator used to treat patients with the relapsing-remitting form of multiple sclerosis (MS) and studied to manage lung complications of COVID-19. Teriflunomide A pyrimidine synthesis inhibitor with anti-inflammatory and immunomodulatory properties used to treat patients with the relapsing-remitting form of multiple sclerosis. Gadoxetic acid A gadolinium-based contrast agent used in magnetic resonance imaging (MRI) to help characterize lesions in the liver. Dabrafenib A kinase inhibitor used to treat patients with specific types of melanoma, non-small cell lung cancer, and thyroid cancer. Adrafinil Used to relieve excessive sleepiness and inattention in elderly patients. Isoxsuprine A beta-adrenergic agonist used in the symptomatic treatment of cerebrovascular insufficiency, peripheral vascular disease of arteriosclerosis obliterans, thromboangiitis obliterans (Buerger's disease) and Raynaud's disease. Indenolol Indenolol is a drug of the beta-adrenergic blocker class. Ibuproxam Ibuproxam is a non steroidal anti-inflammatory drug (NSAID). Hexoprenaline Hexoprenaline is a stimulant of beta 2 adrenergic receptors. It is used as a bronchodilator, antiasthmatic, and tocolytic agent. Hexamethonium A nicotinic cholinergic antagonist often referred to as the prototypical ganglionic blocker. It is poorly absorbed from the gastrointestinal tract and does not cross the blood-brain barrier. It has been... Azosemide Azosemide is a loop diuretic used to treat hypertension, edema, and ascites. Fendiline Fendiline is a coronary vasodilator which inhibits calcium function in muscle cells in excitation-contraction coupling. It has been proposed as an antiarrhythmic and antianginal agent. Fendiline is non-selective. Etofenamate An NSAID used to treat muscle and joint pain. Etilefrine An adrenergic agonist primarily of α1 and β1 receptors used as an anti-hypotensive. Clobutinol Clobutinol is a cough suppressant that is withdrawn from the US and EU markets. Clobutinol may prolong the QT interval. In 2007, Clobutinol was determined to cause cardiac arrhythmia in... Chlorphenoxamine An antihistamine used as an antipruritic. Befunolol Used in the management of open angle glaucoma. PMID: 12480285. Bromhexine A mucolytic drug used to decrease the viscosity of mucus in the airway, enhancing mucus clearance. Benfluorex Benfluorex is an anorectic and hypolipidemic agent that is structurally related to fenfluramine. It was patented and manufactured by a French pharmaceutical company Servier. The European Medicines Agency (EMA) recommended... Miltefosine An antileishmanial agent used to treat leishmaniasis, a group of disease caused by parasites of the Leishmania type. Isosulfan blue A visual lymphatic imaging agent used during lymphography as an adjunct. Florbetaben (18F) A radiopharmaceutical diagnostic agent used during Positron Emission Tomography (PET) imaging of the brain to estimate β-amyloid neuritic plaque density in adult patients to diagnose the causes of cognitive impairment. Florbetapir (18F) A radiopharmaceutical diagnostic agent used during Positron Emission Tomography (PET) imaging of the brain to estimate β-amyloid neuritic plaque density in adult patients to diagnose the causes of cognitive impairment. Technetium Tc-99m exametazime A radiopharmaceutical diagnostic agent used as an adjunct for scintigraphy in the detection of altered regional cerebral perfusion in stroke. Phenaridine Phenaridine (2,5-Dimethylfentanyl) is a synthetic fentanyl derivative opioid. It was developed in 1972, and is used for surgical anasthesia in Russia. Phenaridine has similar effects to fentanyl. In rat studies,... Nisoxetine Nisoxetine is a selective norepinephrine reuptake inhibitor (SNRI) developed in the 1970s. It was originally investigated as an antidepressant but has no current clinical applications aside from being a research... Talopram Talopram is a selective norepinephrine reuptake inhibitor (SNRI) that is structurally similar to citalopram and melitracen. It was researched in the 1960s and 1970s but never marketed. Synephrine Synephrine, also referred to as, p-synephrine, is naturally occurring alkaloid. It is present in approved drug products as neo-synephrine, its m-substituted analog. p-synephrine and m-synephrine are known for their longer... Arotinolol Artinolol was introduced to be used as an antihypertensive agent since 1986. It has been studied for other functions like tremor control for patients with Parkinson disease and it is... Moxisylyte By the WHO, moxisylyte is indicated for the symptomatic management of sequelae of cerebral infarction or hemorrhage. The cerebral infarction is characterized by the blockage of the artery either by... Lumacaftor A protein chaperone used in combination with ivacaftor for the treatment of cystic fibrosis in patients who are homozygous for the F508del mutation in the CFTR gene. Morniflumate An NSAID derived from niflumic acid used in the symptomatic treatment of inflammatory conditions of the airways, ENT, and the urogenital and osteoarticular systems. Butylscopolamine An antispasmodic and anticholinergic agent used for the symptomatic treatment of abdominal cramping and pain. Osimertinib A tyrosine kinase inhibitor used in the treatment of certain types of non-small cell lung carcinoma. Hydroxyamphetamine An indirectly acting sympathomimetic agent producing mydriasis for diagnostic purposes. Iofetamine I-123 Not Annotated Ferric ammonium citrate Not Annotated Thonzonium A cationic surfactant used to disperse exudate and cellular debris, as well as enhance the penetration of antimicrobials. Benzalkonium An antiseptic agent used as a preservative in medications or as a disinfectant in cleaning products. Racepinephrine A bronchodilator used to treat intermittent asthma. Benzethonium A medication used as to clean hands and clean minor cuts and scrapes. Light green SF yellowish Light green SF yellowish is a green triarylmethane dye that is used in the preparation of the staining solution which is widely used as a counterstain. It is used in... Diethylamino hydroxybenzoyl hexyl benzoate Indicated for use as a sunscreen agent. Brilliant green cation An ingredient used in topical medications to prevent infections of the umbilical cord. Ichthammol Ichthammol is also referred to as ammonium bituminosulfonate or ammonium bituminosulphonate. It is an ammonium salt of dark sulfonated shale oil (bituminous schists) produced via distillation of the oil followed... Cocamidopropyl betaine Cocamidopropyl betaine is a mixture of closely related organic compounds derived from coconut oil and dimethylaminopropylamine that typically acts as an amphoteric surfactant in cosmetics and personal care products. It... Amitraz Amitraz is a non-systemic acaricide and insecticide. It was generated in 1969 by the Boots Co. in England. Amitraz presents insect repellent effects and hence, it can be used as... Clorsulon Not Annotated Robenacoxib Robenacoxib is a non-steroidal anti-inflammatory drug used in veterinary medicine for the relief of pain and inflammation in cats and dogs. Sulfachlorpyridazine A sulfonamide antimicrobial used for urinary tract infections and in veterinary medicine. Sulfaethoxypyridazine Not Annotated Sulfanitran Not Annotated Sulfaquinoxaline Sulfaquinoxaline is a veterinary medicine which can be given to cattle and sheep to treat coccidiosis.It is available in Pakistan with Sanna Laboratories in combination with Amprolium and Vitamin K... Ractopamine Not Annotated Cetalkonium An antiseptic used as a preservative or to treat certain topical infections. Etafedrine A beta-2 adrenoceptor agonist used to treat a cough associated with inflamed mucosa. Domiphen Anti-infective (topical), it is used for the treatment of Acute Infectious Dental Diseases and other conditions. Oxilofrine An amphetamine used to treat a cough associated with inflamed mucosa. Afuresertib Afuresertib has been used in trials studying the treatment of Cancer and Neoplasms, Haematologic. Psilocybin Psilocybin has been investigated for the treatment of Anxiety and Stage IV Melanoma. In November, 2019, it was granted Breakthrough Therapy status by the FDA. Buparlisib Buparlisib has been used in trials studying the treatment and basic science of Lymphoma, Metastases, Lung Cancer, Solid Tumors, and Breast Cancer, among others. Ilorasertib Ilorasertib has been used in trials studying the treatment of Myelodysplasia, Solid Neoplasm, Advanced Cancers, Advanced Solid Tumors, and Acute Myelogenous Leukemia, among others. GSK-2330672 GSK2330672 has been investigated for the treatment of Diabetes Mellitus, Type 2. Ribociclib A kinase inhibitor used to treat HR+, HER2- advanced or metastatic breast cancer. Zytron Zytron (DMPA) is under investigation for the treatment and health services research of HIV, Lactation, Contraception, Postpartum Depression, and Immune Cells (Mucosal and Systemic). DMPA has been investigated for the... Talinolol Talinolol has been investigated for the basic science of Gastrointestinal Motility Disorder. Tosedostat Tosedostat has been used in trials studying the treatment and supportive care of AML, Leukemia, Pancreas Cancer, Multiple Myeloma, and Pancreatic Cancer, among others. Tosedostat is an inhibitor of the... Lanicemine Lanicemine has been used in trials studying the treatment and basic science of Depression, Major Depressive Disorder, and Treatment Resistant Major Depressive Disorder. Flumatinib Flumatinib has been used in trials studying the treatment of Myelogenous Leukemia, Chronic. Lanopepden Lanopepden has been used in trials studying the treatment of Pneumonia, Infections, Bacterial, Skin Diseases, Infectious, and Skin Infections, Bacterial. Lesogaberan Lesogaberan has been used in trials studying the treatment and basic science of GERD, Reflux, Heartburn, Regurgitation, and Reflux Disease, among others. Safingol Safingol has been used in trials studying the treatment of Unspecified Adult Solid Tumor, Protocol Specific. Idalopirdine Idalopirdine has been used in trials studying the treatment of Cognition, Schizophrenia, and Alzheimer's Disease. Uprosertib Uprosertib has been used in trials studying the treatment of Cancer, Melanoma, Solid Tumours, Cervical Cancer, and HER2/Neu Negative, among others. Golvatinib Golvatinib has been investigated for the treatment of Platinum-Resistant Squamous Cell Carcinoma of the Head and Neck. Abemaciclib A medication used to treat HR+ HER2- advanced or metastatic breast cancer. Serdemetan Serdemetan has been used in trials studying the treatment of Neoplasms. BMS-777607 BMS-777607 has been investigated for the basic science of Malignant Solid Tumour. Ritobegron Ritobegron is under investigation in clinical trial NCT02256735 (Study to Investigate the Effect of KUC 7483 CL on the QT/QTc Interval of the ECG in Comparison to Placebo and Moxifloxacin... CUDC-101 CUDC-101 has been used in trials studying the treatment of Cancer, Tumors, Liver Cancer, Breast Cancer, and Gastric Cancer, among others. Tulobuterol An inhaled long-acting beta2-adrenergic receptor agonist used as a bronchodilator in the management of asthma and COPD. ABT-751 ABT-751 has been investigated for the treatment of Lung Cancer, Non-Small Cell Lung Cancer, and Non-Small-Cell Lung Cancer. CG-200745 Cg200745 has been used in trials studying the treatment of Solid Tumour. Dasotraline Dasotraline is a serotonin, norepinephrine and dopamine reuptake inhibitor (SNDRI) that is under investigation for the treatment of Binge Eating Disorder, Adult Attention Hyperactivity Disorder, Attention Deficit Hyperactivity Disorder, and... Dopexamine Dopexamine has been used in trials studying the diagnostic and treatment of Free Flap, Oral Cancer, Hypotension, Septic Shock, and Head and Neck Cancer. Navitoclax Navitoclax has been used in trials studying the treatment and basic science of Solid Tumors, Non-Hodgkin's Lymphoma, EGFR Activating Mutation, Chronic Lymphoid Leukemia, and Hematological Malignancies, among others. Navitoclax is... Ricolinostat Ricolinostat is under investigation for the treatment of Breast Carcinoma and Metastatic Breast Cancer. R-306465 R306465 has been used in trials studying the treatment of Neoplasms. Resminostat Resminostat has been used in trials studying the treatment of Sezary Syndrome, Mycosis fungoides, Hodgkin's Lymphoma, Hepatocellular Carcinoma, and Lymphoma, T-Cell, Cutaneous, among others. Mebeverine An antispasmodic used for the symptomatic treatment of stomach pain and spasms associated with irritable bowel syndrome and other gastrointestinal illnesses. Abexinostat Abexinostat has been used in trials studying the treatment of Sarcoma, Lymphoma, Leukemia, Lymphocytic, and Hodgkin Disease, among others. It is a novel, broad-spectrum hydroxamic acid-based inhibitor of histone deacetylase... Ondelopran Ondelopran has been used in trials studying the treatment of Alcohol Dependence. Pentetreotide A somatostatin receptor inhibitor, available in a kit with Indium-111, used as a contrast agent in the visualization of somatostatin receptor-positive neuroendocrine tumours. Emixustat Emixustat has been used in trials studying the treatment of Geographic Atrophy, Age-Related Macular Degeneration, and Dry Age-related Macular Degeneration. Bucindolol Bucindolol has been investigated in Heart Failure. Dichloroisoproterenol Dichloroisoproterenol has been used in trials studying the treatment and basic science of Insulin Resistance and Polycystic Ovary Syndrome. Reproterol A short-acting β2 adrenoreceptor agonist used to treat various types of asthma including allergic asthma, non-allergic asthma, and exercise-induced asthma. Pyroxamide Pyroxamide has been used in trials studying the treatment of Leukemia, Lymphoma, Small Intestine Cancer, Precancerous Condition, and Myelodysplastic Syndromes, among others. Pradigastat Pradigastat has been used in trials studying the treatment of Non-alcoholic Fatty Liver Disease (NAFLD). Chlorsulfaquinoxaline Chlorsulfaquinoxaline has been used in trials studying the treatment of Lung Cancer and Colorectal Cancer. Gallopamil Gallopamil has been used in trials studying the treatment of Asthma. Ozenoxacin A quinolone antibiotic used to treat impetigo caused by susceptible bacteria. Cafedrine Cafedrine is under investigation in clinical trial NCT01311414 (Effect of Cafedrine/Theodrenaline and Urapidil on Cerebral Oxygenation). Theodrenaline Theodrenaline is under investigation in clinical trial NCT01311414 (Effect of Cafedrine/Theodrenaline and Urapidil on Cerebral Oxygenation). Didox Didox has been used in trials studying the supportive care of Gastric Cancer. Quisinostat Quisinostat has been used in trials studying the treatment of Lymphoma, Neoplasms, Myelodysplastic Syndromes, and Advanced or Refractory Leukemia. Tiapride A dopamine D2 and D3 receptor antagonist indicated in the treatment of chorea in Huntington's disease, as well as agitation and anxiety in the elderly or with acute or chronic alcoholism. Mephedrone Mephedrone has been investigated in Alcohol-Related Disorders and Amphetamine-Related Disorders. Levosalbutamol A beta-2 adrenergic receptor agonist used to treat COPD and asthma. Ambroxol acefyllinate A bronchodilator indicated in the symptomatic treatment of bronchopulmonary disorders associated with bronchospasm. Methylbenactyzium Not Annotated Teclozan An antiprotozoal agent indicated in the treatment of intestinal amebiasis. Bamethan Not Annotated Medifoxamine Medifoxamine was marketed as an atypical antidepressant, with anxiolyitc properties in France, Spain, and Morrocco in the 1990s but was later withdrawn from the market due to it causing cases... Propanidid An intravenous anesthetic that has been used for rapid induction of anesthesia and for maintenance of anesthesia of short duration. (From Martindale, The Extra Pharmacopoeia, 30th ed, p918) Neltenexine Neltenexine is an elastase inhibitor. It may be useful for preventing pulmonary emphysema. Phthalylsulfathiazole A sulfonamide antibacterial indicated in the treatment of gastrointestinal infections. Octopamine Octopamine is structurally similar to norepinephrine. It has been used as a nootropic, and therefore it and all of its enantiomer are prohibited by the World Anti-doping Agency (WADA) as... Bucetin Bucetin is an analgesic and antipyretic medication which was approved for use in Germany but was withdrawn from the market in 1986 due to renal toxicity caused by the medication... Benzododecinium Benzododecinium is used as an antiseptic/disinfectant compound. It has been marketed as a tincture for antiseptic product for wounds in the Czech Republic. Sulfaisodimidine Sulfaisodimidine also called sulfisomidine is an antibacterial product that has been studied for the treatment of urinary tract infections in the 1950s, however, it is unclear whether this drug has... Olaflur A fluoride treatment for patients at risk of dental caries, sensitive teeth, or enamel decalcification. Idrocilamide Not Annotated Tolpropamine Not Annotated Melevodopa A methyl ester of levodopa indicated in combination with carbidopa for the treatment of Parkinson's disease. Ibopamine A sympathomimetic, indicated in the induction of mydriasis and treatment of pos-surgical ocular hypotonia. Suloctidil Not Annotated Bufexamac An NSAID used to treat skin conditions like atopic eczema and inflammatory dermatoses. Deanol Deanol is commonly referred to as 2-(dimethylamino)ethanol, dimethylaminoethanol (DMAE) or dimethylethanolamine (DMEA). It holds tertiary amine and primary alcohol groups as functional groups. Deanol has been used in the treatment... Viminol An opioid analgesic indicated in the treatment of pain. Norfenefrine Not Annotated Sodium feredetate Not Annotated Adrenalone Not Annotated Oxyfedrine Not Annotated Thiazinam Not Annotated Dimetofrine Not Annotated Valethamate An anticholinergic medication used to symptomatically manage conditions involving smooth muscle spasms including spastic constipation, dysmenorrhea, and gastrointestinal tract cramping. Otilonium A spasmolytic medication used to treat irritable bowel syndrome (IBS). Emepronium Not Annotated Cloranolol Not Annotated Mepindolol Mepindolol is a 2-methyl derivative of pindolol. It is a beta blocker. Sulfatolamide Not Annotated 4-dimethylaminophenol Not Annotated Clobenzorex Not Annotated Benzoxonium An antiseptic indicated in skin disinfection and prevention of infections. Heptaminol A cardiac stimulant and vasodilator indicated in the treatment of hemorrhoids and venolymphatic insufficiency. Succinylsulfathiazole Not Annotated Gallamine Not Annotated Calcium pangamate Not Annotated Melagatran Not Annotated Methoxyphenamine Not Annotated Carbuterol Not Annotated Tenitramine Not Annotated Alcuronium A non-depolarizing skeletal muscle relaxant similar to tubocurarine. It is used as an anesthesia adjuvant. Penthienate Not Annotated Sulfathiourea Not Annotated Gepefrine Not Annotated Decamethoxine Not Annotated Trolnitrate Not Annotated Terodiline Not Annotated Sulfaguanidine Not Annotated Trolamine Trolamine is used as an alkalizing agent, surfactant, and counter-ion in cosmetic and pharmaceutical formulations . It is not considered to be an active pharmacological ingredient and so has no... Obidoxime Not Annotated Epanolol Epanolol is an beta blocker. Sulfamethoxypyridazine A sulphonamide antibiotic indicated in the treatment of gonorrhea, inflammation, urinary tract ulcers, and bronchitis. Tertatolol Tertatolol is a beta blocker. Prenalterol Not Annotated Xamoterol Xamoterol is a β1-adrenoceptor partial agonist that has shown to improve systolic and diastolic function in studies with heart failure patients. It modulates the sympathetic control of the heart but... Mefenorex Not Annotated Enasidenib An isocitrate dehydrogenase-2 inhibitor used to treat relapsed or refractory acute myeloid leukemia with an isocitrate dehydrogenase-2 mutation. Deoxyepinephrine Sympathomimetic, vasoconstrictor agent. 2,5-Dimethoxy-4-ethylthioamphetamine 2,5-Dimethoxy-4-ethylthioamphetamine (ALEPH-2) is a phenylisopropylamine derivative with alleged anxiolytic and hallucinogenic properties. Dioctyldimonium Not Annotated Choline salicylate The oral gel is indicated for the relief of pain and discomfort of common mouth ulcers, cold sores, denture sore spots, infant teething and mouth ulcers, and sore spots due... Pentetic acid DTPA is widely used in industry and medicine. As a medical agent, it is approved for its use in medical imaging and for the decorporation of internally deposited radionuclides. It... Bromotheophylline Bromotheophylline is used as a diuretic and also, in combination with DB00316, it is used for the relief of temporary water weight gain, bloating, swelling and full feeling associated with... Acetyl sulfisoxazole Acute, recurrent or chronic urinary tract infections (primarily pyelonephritis, pyelitis and cystitis) due to susceptible organisms (usually Escherichia coli, Klebsiella-Enterobacter, staphylococcus, Proteus mirabilis and, less frequently, Proteus vulgaris) in the... Palmidrol A cannabinoid receptor-inactive eCB-related molecule used as prophylactic in helping to prevent respiratory viral infection. Palmidrol is available for human use as a supplement (400 mg capsules) and as food... Dexverapamil Not Annotated Emopamil Prevents renal injury after warm & cold ischemia. Desmethylsertraline Desmethylsertraline is a metabolite of sertraline. Phytosphingosine Not Annotated p-Phenylenediamine Not Annotated Distearyldimonium Not Annotated p-Aminophenol Not Annotated Ethylenediamine Ethylenediamine is approved for use within allergenic epicutaneous patch tests which are indicated for use as an aid in the diagnosis of allergic contact dermatitis (ACD) in persons 6 years... N,N'-diphenyl-1,4-phenylenediamine Not Annotated 4-(Isopropylamino)diphenylamine 4-(Isopropylamino)diphenylamine is approved for use within allergenic epicutaneous patch tests which are indicated for use as an aid in the diagnosis of allergic contact dermatitis (ACD) in persons 6 years... Quaternium-15 Quaternium-15 is approved for use within allergenic epicutaneous patch tests which are indicated for use as an aid in the diagnosis of allergic contact dermatitis (ACD) in persons 6 years... N-Cyclohexyl-N'-phenyl-1,4-phenylenediamine N-Cyclohexyl-N'-phenyl-1,4-phenylenediamine is approved for use within allergenic epicutaneous patch tests which are indicated for use as an aid in the diagnosis of allergic contact dermatitis (ACD) in persons 6 years... Patent Blue A dye used to label lymphatic vessels, arterial territories, and lymph nodes prior to biopsy in some cancers. Tyramine O-sulfate Not Annotated Dexpropranolol Not Available Clorgiline An antidepressive agent and monoamine oxidase inhibitor related to PARGYLINE. Didecyldimethylammonium A disinfectant and microbicidal agent used in a variety of products. N-acetylserotonin Not Available PD-0325901 PD-0325901 has been used in trials studying the treatment and basic science of Melanoma, Solid Tumour, Solid Tumors, Advanced Cancer, and Breast Neoplasms, among others. CTS-1027 CTS-1027 has been used in trials studying the treatment of Hepatitis C and Chronic Hepatitis C Virus Infection. Amifampridine A voltage gated potassium channel blocker used to treat Lambert-Eaton myasthenic syndrome. Gilteritinib An AXL receptor tyrosine kinase inhibitor used to treat relapsed or refractory acute myeloid leukemia. Citicoline An endogenous intermediate in the formation of phosphatidylcholine from choline which is thought to have neuroprotective effects. Glutamine hydroxamate Not Available Diethyltryptamine Diethyltryptamine (DET) is an orally active hallucinogenic agent and a substituted form of tryptamine. Alprazolam A triazolobenzodiazepine with intermediate onset commonly used to treat panic disorders and generalized anxiety in addition to anxiety associated with depression. 2-(aminomethyl)phenol 2-(aminomethyl)phenol is under investigation in clinical trial NCT03556319 (2-HOBA: Multiple Dosing Study in Older Adults). Martinostat Martinostat is under investigation in clinical trial NCT03721211 (Imaging With [11C]Martinostat in Breast Cancer). Miransertib Miransertib is under investigation in clinical trial NCT01473095 (Phase 1 Dose Escalation Study of ARQ 092 in Adult Subjects With Advanced Solid Tumors and Recurrent Malignant Lymphoma). AZD-8186 AZD-8186 is under investigation in clinical trial NCT03218826 (PI3Kbeta Inhibitor AZD8186 and Docetaxel in Treating Patients Advanced Solid Tumors With PTEN or PIK3CB Mutations That Are Metastatic or Cannot Be... Flutemetamol Flutemetamol is under investigation in clinical trial NCT02353949 (Investigating the Clinical Consequences of Flutemetamol-PET-scanning). Pittsburgh Compound B Pittsburgh Compound B is under investigation in clinical trial NCT01723553 (Amyloid-related Imaging Abnormalities (Microbleeds) in Atypical AD). Bixalomer Bixalomer is under investigation in clinical trial NCT01115985 (A Study to Assess the Effect of ASP1585 on Pharmacokinetics of Atorvastatin in Healthy Volunteers). VS-4718 VS-4718 is under investigation in clinical trial NCT02215629 (Dose Escalation Study in Acute Myeloid or B-Cell Acute Lymphoblastic Leukemia). Tefinostat Tefinostat is under investigation in clinical trial NCT02759601 (Dose Escalation Trial of Tefinostat for Cancer Associated Inflamation in Hepatocellular Carcinoma (HCC)). Lidocaine A local anesthetic used in a wide variety of superficial and invasive procedures. Ropivacaine An analgesic drug used for local or regional anesthesia for surgery and short-term management of pain. Bupivacaine A local anesthetic used in a wide variety of superficial and invasive procedures. Acetaminophen An analgesic drug used alone or in combination with opioids for pain management, and as an antipyretic agent. Flutamide An antiandrogen used for locally confined stage B2-C and D-2 metastatic prostate carcinoma. Diclofenac An NSAID used to treat the signs and symptoms of osteoarthritis and rheumatoid arthritis. Prilocaine A local anesthetic used in dental procedures. Gabapentin An anticonvulsant medication used in the management of peripheral neuropathic pains, postherpetic neuralgia, and partial-onset seizures. Levobupivacaine A drug used for nerve block and anesthesia. Tocainide An orally active class 1b antiarrhythmic agent that interferes with cardiac sodium channels and typically used to treat ventricular arrhythmias. Bicalutamide An androgen receptor inhibitor used to treat Stage D2 metastatic carcinoma of the prostate. Encainide A voltage-gated sodium channel blocker used for management of atrial or ventricular fibrillation, atrial flutter, and ventricular tachycardia, that is no longer used due to proarrhythmic adverse effects. Methylenedioxyethamphetamine Not Available Phenacetin Used principally as an analgesic. Carboxin A systemic agricultural fungicide and seed treatment agent. Eprotirome Investigated for use/treatment in hyperlipidemia, metabolic disease, and obesity. NCX 701 Investigated for use/treatment in pain (acute or chronic). UC-781 Investigated for use/treatment in HIV infection. Niclosamide An anthelmintic indicated in the treatment of beef, pork, fish, and dwarf tapeworm infections in adults and children. S-23 An androgen receptor modulator. Platensimycin Not Available Vismodegib A hedgehog pathway inhibitor used to treat patients with locally advanced or metastatic basal cell carcinoma. Crizotinib A receptor tyrosine kinase inhibitor used to treat metastatic non-small cell lung cancer (NSCLC) where the tumors have been confirmed to be anaplastic lymphoma kinase (ALK), or ROS1-positive. Cabozantinib A tyrosine kinase inhibitor used to treat advanced renal cell carcinoma, hepatocellular carcinoma, and medullary thyroid cancer. Mirabegron A beta-3 adrenergic agonist used to treat overactive bladder and neurogenic detrusor overactivity. Etidocaine Etidocaine is marketed under the name Duranest. It is an injectable local anesthetic during surgery, labor, and delivery. Etidocaine has a long duration of activity, but has the main disadvantage... Flutemetamol (18F) A radiopharmaceutical diagnostic agent used during Positron Emission Tomography (PET) imaging of the brain to estimate β-amyloid neuritic plaque density in adult patients to diagnose the causes of cognitive impairment. Propacetamol Propacetamol is a paracetamol prodrug of intravenous administration used to control fever and pain of perioperative period in multimodal analgesia therapy. Ombitasvir A direct acting antiviral agent used in combination with other antiviral agents for the treatment of Hepatitis C Virus (HCV) infections. Triclocarban An antibacterial agent used in liquid soaps and body washes. Nicarbazin Not Annotated Imidocarb Imidocarb is a urea derivative used in veterinary medicine as an antiprotozoal agent for the treatment of infection with Babesia and other parasites. Epacadostat Epacadostat has been used in trials studying the treatment of HL, Melanoma, Glioblastoma, Mucosal Melanoma, and Ovarian Carcinoma, among others. Enobosarm Enobosarm has been used in trials studying the treatment of Stress Urinary Incontinence and Triple Negative Breast Cancer. Foretinib Foretinib has been used in trials studying the treatment of Cancer, Breast Cancer, Carcinoma, Renal Cell, Recurrent Breast Cancer, and Neoplasms, Head and Neck, among others. Foretinib is an orally... Pilsicainide Pilsicainide has been investigated for the treatment of Paroxysmal Atrial Fibrillation. Inosine pranobex A medication used to treat subacute sclerosing panencephalitis. Butanilicaine Not Annotated Benorilate Not Annotated Reposal Reposal is a barbiturate derivative invented in the 1960s in Denmark that has sedative, hypnotic and anticonvulsant properties. It was used primarily in the treatment of insomnia. Fluorodopa (18F) Fluorodopa F 18 is indicated for use with positron emission tomography (PET) to visualize dopaminergic nerve terminals in the striatum for the evaluation of adult patients with suspected Parkinsonian syndromes... Ulixertinib Ulixertinib is a a novel, reversible, ATP-competitive ERK1/2 inhibitor with high potency and ERK1/2 selectivity . It is currently in clinical trials for the treatment of a wide range of... Tosylchloramide A chlorinated disinfectant of the genitals and injured skin. Mebenil An obsolete fungicide used to control various pathogens on cereals and seed potatoes. Mavacamten Mavacamten is under investigation in clinical trial NCT03442764 (A Phase 2 Study of Mavacamten in Adults With Symptomatic Non-Obstructive Hypertrophic Cardiomyopathy (nHCM)). Avacopan Avacopan is under investigation in clinical trial NCT02994927 (A Phase 3 Clinical Trial of CCX168 (Avacopan) in Patients With ANCA-Associated Vasculitis). Sitravatinib Sitravatinib is under investigation in clinical trial NCT03680521 (Neoadjuvant Sitravatinib in Combination With Nivolumab in Patients With Clear Cell Renal Cell Carcinoma). Birabresib Birabresib is under investigation in clinical trial NCT02698176 (A Dose Exploration Study With MK-8628 in Participants With Selected Advanced Solid Tumors (MK-8628-006)). Pexidartinib An antitumor agent that is used for the treatment of rare disease tenosynovial giant cell tumors (TGCT) by inhibiting colony-stimulating factor 1 and its receptor. 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide Not Available 6-bromoindirubin-3'-oxime Not Available Brilliant blue G A disclosing agent used in ophthalmological surgery to stain the internal limiting membrane (ILM). GW-3965 GW-3965 is a liver X receptor ligand. Trichostatin A Not Available Betaine aldehyde Not Available Andarine Andarine is a non-steroidal selective androgen receptor modulator. CGS-27023 Not Available N-Caffeoyltyramine Not Available Ilomastat Not Available Tryptamine Not Available Dodecyltrimethylammonium Not Available Lauryldimethylbetaine Not Available Cumidine Not Available 3-(cyclohexylamino)propanesulfonic acid Not Available NAP-226-90 Not Available Tetramethylammonium Not Available Cadaverine Cadaverine is a foul-smelling diamine formed by bacterial decarboxylation of lysine. Dodecyldimethylamine N-oxide Not Available MDL72527 Not Available 8-anilinonaphthalene-1-sulfonic acid Not Available Carmoterol A long acting beta-2 agonist indicated in the treatment of COPD, asthma, and chronic bronchitis. Cetyltrimethylammonium naproxenate An anti-inflammatory and antiseptic agent indicated to treat mouth inflammation and pain , including that caused by tooth extraction. Fluorocholine F-18 A radiopharmaceutical indicated in PET scans of the prostate. Fepradinol Not Annotated Sulfametrole An antibiotic indicated in combination intravenous products for various bacterial infections. Gallium Ga-68 gozetotide A radiopharmaceutical agent used in the diagnosis of prostate-specific membrane antigen (PSMA) positive lesions in male patients during positron emission tomography. TRO40303 TRO40303 is under investigation in clinical trial NCT01374321 (Safety and Efficacy Study of TRO40303 for Reduction of Reperfusion Injury in Patients Undergoing Percutaneous Coronary Intervention for Acute Myocardial Infarction). V116517 V116517 is under investigation in clinical trial NCT01688947 (Analgesic Efficacy and Safety of V116517 in Subjects With Moderate to Severe Chronic Pain Due to Postherpetic Neuralgia (PHN)). GSK2256098 GSK2256098 is under investigation in clinical trial NCT02523014 (Vismodegib and FAK Inhibitor GSK2256098 in Treating Patients With Progressive Meningiomas). GED-0507-34-Levo GED-0507-34-Levo is under investigation in clinical trial NCT02808390 (Efficacy and Safety Study of Ged-0507-34-levo for Treatment of UC). Capadenoson Capadenoson is under investigation in clinical trial NCT00518921 (Capadenoson in Angina Pectoris). Chiauranib Chiauranib is under investigation in clinical trial NCT03974243 (Chiauranib in Combination With Chidamide in Patients With Relapsed/refractory Non-hodgkin's Lymphoma). Acetyldinaline Acetyldinaline is under investigation in clinical trial NCT00005624 (CI-994 in Treating Patients With Advanced Myeloma). Dopastatin Dopastatin is under investigation in clinical trial NCT04335357 (TBR-760 in Adult Patients With Non-functioning Pituitary Adenomas). NSI-189 NSI-189 is under investigation in clinical trial NCT02695472 (Study of NSI-189 for Major Depressive Disorder). Methfuroxam Methfuroxam is under investigation in clinical trial NCT01213407 (Dendritic Cell Cancer Vaccine for High-grade Glioma). Naphthoquine Naphthoquine is under investigation in clinical trial NCT01930331 (Safety, Tolerability, Pharmacokinetics and Efficacy of ARCO). Nolasiban Nolasiban is under investigation in clinical trial NCT03081208 (Phase 3 Placebo Controlled Study of Nolasiban to Improve Pregnancy Rates in Women Undergoing IVF/ICSI). Razuprotafib Razuprotafib, also known as AKB-9778, is a small-molecule inhibitor restoring Tie2 activation by inhibiting VE-PTP.[L27171,L27176] In investigations against diabetes and COVID-19, razuprotafib is self-administered by patients through subcutaneous injection. Oleic monoethanolamide Not Available DL-Methylephedrine Used as an antitussive and decongestant . Amidephrine A sympathomimetic indicated in the treatment of acute, chronic, vasomotor, and allergic rhinitis. Caprylhydroxamic acid Not Annotated PG-530742 Investigated for use/treatment in osteoarthritis. Piroctone Piroctone olamine is used in combination with other substances as a part of shampoo effectively reduced the amount of dandruff and, at the same time, provided hair conditioning advantages. Recently... Famprofazone Famprofazone is a nonsteroidal anti-inflammatory agent found in combination products such as ‘Gewodin’ which is marketed in Taiwan. It is important to note that the drug is metabolized to methamphetamine...
- Drugs & Drug Targets