Benzene Derivatives
- Name
- Benzene Derivatives
- Accession Number
- DBCAT000418
- Description
Organic compounds derived from BENZENE.
- Drugs
Drug Drug Description Mesalazine An aminosalicylate drug used to treat mild to moderate active ulcerative colitis and also to maintain remission once achieved. Tolcapone A catechol-O-methyltransferase (COMT) inhibitor used as adjunct therapy in the symptomatic management of idiopathic Parkinson's disease. Terfenadine An antihistamine for the treatment of allergy symptoms. Sulpiride A selective D2 dopamine receptor antagonist indicated to treat chronic and acute schizophrenia. Remoxipride An discontinued atypical antipsychotic selective for dopamine D2 receptors. Methocarbamol A CNS depressant indicated with rest, physical therapy and other treatments to control the discomfort associated with various acute musculoskeletal conditions. Raloxifene A selective estrogen receptor modulator that is used to prevent and treat osteoporosis and reduce the risk of invasive breast cancer in high-risk postmenopausal women. Entacapone A selective reversible catechol-O-methyltransferase inhibitor for the treatment of Parkinson's disease. Toremifene A first generation nonsteroidal selective estrogen receptor modulator used to treat certain breast cancers. Bacitracin A cyclic polypeptide antibiotic used to prevent wound infections, treat pneumonia and empyema in infants, and to treat skin and eye infections. Tamoxifen A selective estrogen receptor modulator used to treat estrogen receptor positive breast cancer, reduce the risk of invasive breast cancer following surgery, or reduce the risk of breast cancer in high risk women. Losartan An angiotensin receptor blocker used to treat hypertension and diabetic nephropathy, and is used to reduce the risk of stroke. Furosemide A loop diuretic used to treat hypertension and edema in congestive heart failure, liver cirrhosis, renal disease, and hypertension. Flurbiprofen An NSAID used to treat the signs and symptoms of osteoarthritis and rheumatoid arthritis. Procaine A local anesthetic used for anesthesia, peripheral nerve block, and spinal nerve block. Meclizine A histamine H1 antagonist used to treat nausea, vomiting, and dizziness associated with motion sickness. Mefenamic acid An NSAID used to treat mild to moderate pain for no more than a week, and primary dysmenorrhea. Proparacaine A topical anesthetic used for ophthalmic practice. Guaifenesin An expectorant commonly found in OTC products for the symptomatic relief from congested chests and coughs associated with cold, bronchitis, and/or other breathing illnesses. Acetylsalicylic acid A salicylate used to treat pain, fever, inflammation, migraines, and reducing the risk of major adverse cardiovascular events. Fexofenadine A selective H1-antagonist for the symptomatic treatment of seasonal allergic rhinitis and chronic idiopathic urticaria. Bromfenac An NSAID used to treat postoperative pain and inflammation of the eye. Telmisartan An ARB used to treat hypertension, diabetic nephropathy, and congestive heart failure. Dimenhydrinate A medication used to prevent and treat nausea, vomiting, vertigo, and motion sickness. Irbesartan An angiotensin receptor blocker used to treat hypertension, delay progression of diabetic nephropathy, and treat congestive heart failure. Fenofibrate A peroxisome proliferator receptor alpha activator used to lower LDL-C, total-C, triglycerides, and Apo B, while increasing HDL-C in hypercholesterolemia, dyslipidemia, and hypertriglyceridemia. Diphenhydramine A H1 receptor antihistamine used in the treatment of seasonal allergies, and various allergic reactions including sneezing, runny nose, itchy/watery eyes, itching of nose or throat, pruritus, urticaria, insect bites/stings, and allergic rashes. Benzocaine A topical local anesthetic used for the temporary relief of pain and itching associated with minor burns, sunburn, scrapes and insect bites or minor skin irritations. Bicalutamide An androgen receptor inhibitor used to treat Stage D2 metastatic carcinoma of the prostate. Orphenadrine A muscarinic antagonist used as an adjunct for the symptomatic relief of musculoskeletal pain and discomfort. Gemfibrozil A lipid regulator that is used in the reduction of serum triglyceride levels in high-risk patients with hyperlipidemia. Bismuth subsalicylate An antidiarrheal and anti-inflammatory agent used for symptomatic treatment of nausea, indigestion, upset stomach, diarrhea, and other temporary discomforts of the stomach and gastrointestinal tract. Iohexol A contrast agent for intrathecal administration used in myelography and contrast enhancement for computerized tomography. Amisulpride A dopamine D2 receptor antagonist used in the treatment of acute and chronic schizophrenia, and in the prevention and treatment of postoperative nausea and vomiting in adults. Dapagliflozin A sodium-glucose cotransporter 2 inhibitor used in the management of type 2 diabetes mellitus. Desvenlafaxine An antidepressant agent and SNRI used for the treatment of major depressive disorders in adults. Nepafenac An ophthalmic NSAID used for the symptomatic treatment of pain and inflammation associated with cataract surgery. Chloramphenicol succinate A broad-spectrum antibiotic agent used for the treatment of acute and severe infections caused by susceptible bacterial strains. Ivacaftor A cystic fibrosis transmembrane conductance regulator (CFTR) potentiator used alone or in combination products to treat cystic fibrosis in patients who have specific genetic mutations that are responsive to the medication. Bisacodyl A stimulant laxative used for the temporary relief of occasional constipation and cleansing of the colon as a preparation for colonoscopy in adults. Empagliflozin An SGLT2 inhibitor used to manage type 2 diabetes mellitus. Benzoyl peroxide An antibacterial and anti-inflammatory agent used for the symptomatic treatment of mild to moderate acne vulgaris and rosacea. Fimasartan An angiotensin II receptor antagonist (ARB) used to treat hypertension and heart failure. Triclocarban An antibacterial agent used in liquid soaps and body washes. Toluene Used for the removal of ascarids (Toxocara canis and Toxascaris leonina) and hookworms (Ancylostoma caninum and Uncinaria stenocephala) and as an aid in removing tapeworms (Taenia pisiformis, Dipylidium caninum, and... Acalabrutinib A Bruton tyrosine kinase inhibitor used to treat mantle cell lymphoma, chronic lymphocytic leukemia, and small lymphocytic lymphoma. Tivozanib A kinase inhibitor to treat adult patients with renal cell carcinoma (RCC) who have failed prior systemic therapies or experienced relapsed disease. Relugolix An oral GnRH receptor antagonist for androgen deprivation therapy in the treatment of advanced prostate cancer. Revefenacin An anticholinergic agent used to treat COPD. Infigratinib An FGFR inhibitor used to treat locally advanced or metastatic cholangiocarcinoma in adults with a fibroblast growth factor receptor 2 (FGFR2) rearrangement. Glasdegib A sonic hedgehog receptor inhibitor used to treat newly diagnosed acute myeloid leukemia in patients over 75 years who cannot receive intense chemotherapy. Entrectinib Entrectinib is indicated for the treatment of metastatic ROS1-positive non-small cell lung cancer in adults. Entrectinib is also indicated in adults and children over 12 years old for the treatment... Siponimod A medication used to treat relapsing multiple sclerosis. Tazemetostat A methyltransferase inhibitor indicated to treat patients 16 years and older with metastatic or locally advanced epithelioid sarcoma not eligible for complete resection. Aliskiren A direct renin inhibitor used to manage hypertension. RSV-604 RSV-604 is under investigation in clinical trial NCT00416442 (Safety, Tolerability and Pharmacokinetic Study of Single and Multiple Intravenous Doses of RSV604 in Healthy Subjects.). Carbidopa A dopa decarboxylase inhibitor used in combination with levodopa for the symptomatic treatment of idiopathic Parkinson disease and other conditions associated with parkinsonian symptoms. Alprazolam A triazolobenzodiazepine with intermediate onset commonly used to treat panic disorders and generalized anxiety in addition to anxiety associated with depression. Dipivefrin A prodrug of epinephrine used in ophthalmic solutions to reduce intraocular pressure in chronic open-angle glaucoma. Methyldopa A centrally-acting alpha-2 adrenergic agonist used to manage hypertension alone or in combination with hydrochlorothiazide, and to treat hypertensive crises. Isoprenaline A catecholamine non-selective beta-adrenergic agonist typically used to treat bradycardia and heart block. Levodopa A dopamine precursor used in the management of Parkinson's disease, often in combination with carbidopa, as well as other conditions associated with parkinsonism. Fluorodopa (18F) Fluorodopa F 18 is indicated for use with positron emission tomography (PET) to visualize dopaminergic nerve terminals in the striatum for the evaluation of adult patients with suspected Parkinsonian syndromes... Dichlorobenzene Dichlorobenzene refers to any of, or a mixture of, three isomers consisting of benzene in which two of the hydrogen atoms are replaced by chlorine atoms: ortho-, meta-, and paradichlorobenzene.... Capmatinib A kinase inhibitor targeting c-Met receptor tyrosine kinase in the treatment of non-small cell lung cancer with MET exon 14 skipping. Anethole An excipient added to medications for flavouring. Trimethobenzamide An antiemetic used to treat postoperative nausea and vomiting and nausea associated with gastroenteritis. Benzyl benzoate A topical treatment for scabies and lice. Haloprogin Used to treat fungal (Tinea) skin infections such as athlete's foot, jock itch, ringworm, and tinea versicolor. Candesartan cilexetil An angiotensin receptor blocker used to treat hypertension, systolic hypertension, left ventricular hypertrophy, and delay progression of diabetic nephropathy. Salicylic acid An acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. Olsalazine An anti-inflammatory aminosalicylate used in the treatment of inflammatory bowel disease and ulcerative colitis. Magnesium salicylate An NSAID analgesic used in the symptomatic relief of mild to moderate muscular pain. Salsalate A nonsteroidal anti-inflammatory agent used in the symptomatic relief of rheumatoid arthritis, osteoarthritis and related rheumatic disorders. Choline magnesium trisalicylate Choline magnesium trisalicylate is used to reduce pain and inflammation caused by conditions such as arthritis. This medication is also used to treat fever in adults. Oxybenzone A sunscreen agent found in sunscreens that absorbs UV rays. Roflumilast A selective phosphodiesterase-4 inhibitor indicated to decrease the risk of exacerbations in patients with severe chronic obstructive pulmonary disease (COPD) and to treat plaque psoriasis. Benzene Hexacarboxylic Acid Not Available 2-Aminophenol Not Available Piclamilast Piclamilast (RP-73,401), is a selective PDE4 inhibitor comparable to other PDE4 inhibitors for its anti-inflammatory effects. It has been investigated for its applications to the treatment of conditions such as... Benzophenone An ingredient used in sunscreens to absorb UV radiation. 3-(5-amino-7-hydroxy-(1,2,3)triazolo(4,5-d)pyrimidin-2-yl)benzoic acid Not Available 2,4,6-Tribromophenol Not Available 4-guanidinobenzoic acid Not Available Thymol An essential oil found in various over-the-counter antibacterial and antifungal products. 2-Allylphenol Not Available Pyromellitic Acid Not Available 2,4-Dihydroxybenzoic Acid Not Available Arotinoid acid Arotinoid acid is a retinoic acid analog which acts as a selective RAR agonist. 3-Methoxybenzamide Not Available Pentabromophenol Not Available KB-141 An anticholesteremic agent. 4-Fluorobenzylamine Not Available Brequinar Not Available 4-(trifluoromethyl)phenol Not Available GW-3965 GW-3965 is a liver X receptor ligand. 3,4-Dihydroxybenzoic Acid Not Available Balanol Not Available Trichostatin A Not Available 1-(4-Amidinophenyl)-3-(4-Chlorophenyl)Urea Not Available NAP-226-90 Not Available o-Bromophenol Not Available Lefradafiban For the treatment of unstable angina. Tesmilifene Intended for the treatment of various forms of cancer. Renzapride For the treatment of constipation-predominant irritable bowel syndrome (IBS-C). Itopride An acetylcholine esterase inhibitor and dopamine D2 receptor antagonist used to treat symptoms of functional dyspepsia such as nausea and vomiting. Tamibarotene Investigated for use/treatment in leukemia (unspecified). ADL5859 Investigated for use/treatment in pain (acute or chronic). TG-100801 Investigated for use/treatment in macular degeneration. INCB3284 Investigated for use/treatment in inflammatory disorders (unspecified). LX1031 Irritable bowel syndrome (IBS) and other gastrointestinal disorders APD791 For the treatment and prophylaxis of arterial thrombosis. Naronapride Investigated for use/treatment in gastroesophageal reflux disease (GERD) and gastroparesis. SB-743921 Investigated for use/treatment in cancer/tumors (unspecified) and lymphoma (non-hodgkin's). TG100-115 Investigated for use/treatment in angioedema and myocardial infarction. SLx-4090 Investigated for use/treatment in hyperlipidemia. Sivifene Investigated for use/treatment in cervical dysplasia/cancer, genital warts, and skin cancer. AGI-1096 Investigated for use/treatment in transplant (rejection). SNX-5422 Investigated for use/treatment in cancer/tumors (unspecified). Ispinesib Investigated for use/treatment in breast cancer, lung cancer, solid tumors, renal cell carcinoma, pediatric indications, ovarian cancer, and head and neck cancer. Solabegron Investigated for use/treatment in diabetes mellitus type 2, irritable bowel syndrome (IBS), and urinary incontinence. Bimosiamose Investigated for use/treatment in asthma, psoriasis and psoriatic disorders, atopic dermatitis, inflammatory disorders (unspecified), and chronic obstructive pulmonary disease (COPD). Eltrombopag A thrombopoietin receptor agonist used to treat thrombocytopenia or aplastic anemia associated with various etiologies. Vernakalant An antiarrhythmic medication used to treat patients with atrial fibrillation. Dersalazine Investigated for use/treatment in inflammatory bowel disease. Tanomastat Investigated for use/treatment in pancreatic cancer, lung cancer, ovarian cancer, and osteoarthritis. Onalespib Investigated for use/treatment in cancer/tumors (unspecified). BNC105 Investigated for use/treatment in cancer/tumors (unspecified). Tucidinostat Investigated for use/treatment in cancer/tumors (unspecified). FK-960 Investigated for use/treatment in dementia, alzheimer's disease, schizophrenia and schizoaffective disorders, and memory loss. Fradafiban Investigated for use/treatment in angina. Aplaviroc Investigated for use/treatment in HIV infection. Tonabersat Investigated for use/treatment in migraine and cluster headaches. Saredutant Investigated for use/treatment in depression and anxiety disorders. Lixivaptan Investigated for use/treatment in hyponatremia and congestive heart failure. Odanacatib Investigated for use/treatment in osteoporosis . Phenyl aminosalicylate Not Annotated p-Cumylphenol Not Available Bisphenol A Not Available Mirdametinib PD-0325901 has been used in trials studying the treatment and basic science of Melanoma, Solid Tumour, Solid Tumors, Advanced Cancer, and Breast Neoplasms, among others. Andarine Andarine is a non-steroidal selective androgen receptor modulator. Sobetirome Not Available Bisphenol Z Not Available PH-797804 PH-797804 has been investigated for the treatment of Osteoarthritis. ABT-341 ABT-341 is a potent and selective DPP-4 inhibitor with a structure very similar to sitagliptin (in 2D; the 3D structure is significantly different). p-Benzoyl-L-phenylalanine Not Available Salicylamide Salicylamide is the common name for the substance o-hydroxybenzamide, or amide of salicyl. Salicylamide is a non-prescription drug with analgesic and antipyretic properties. It has similar medicinal uses to aspirin.... Cinitapride A benzamide with gastroprokinetic and antiemetic properties typically used for the treatment of gastrointestinal motility disorders such as gastroesophageal reflux disease (GERD), non-ulcer dyspepsia, and delayed gastric emptying. Triflusal A medication related to acetylsalicylic acid with antithrombotic effects used in the treatment of thromboembolic diseases. Enzalutamide A second-generation androgen receptor inhibitor used to treat castration-resistant prostate cancer and metastatic castration-sensitive prostate cancer. Etamivan Etamivan (INN) or ethamivan (USAN) is marketed under the name Analepticon. Etamvin is a respiratory stimulant drug similar to nikethamide. It is no longer used in the United States. Amylocaine A local and topical anaesthetic agent. Sonidegib An antineoplastic agent used for the treatment of locally advanced recurrent basal cell carcinoma (BCC) following surgery and radiation therapy, or in cases where surgery or radiation therapy are not appropriate. Sacubitril A neprilysin inhibitor used in combination with valsartan as an adjunct to reduce the risk of cardiovascular death and hospitalization for heart failure in patients with chronic heart failure (NYHA Class II-IV) and reduced ejection fraction. Mequinol A topical agent used in combination with tretinoin to treat solar lentigines. Methyl salicylate A topical counter-irritant used for the symptomatic relief of acute musculoskeletal pain in the muscles, joints, and tendons. Octisalate Ingredient in sunscreens for protection against damage effects of sun light, provides protection from sunburns, aging and skin cancer. Homosalate As ingredient in many sunscreen for protection against sunburn, skin aging and skin cancer. Phenyl salicylate Pain and fever . Trolamine salicylate A medication used to relieve minor aches and pains of the muscles and joints. Sulisobenzone An ingredient used in sunscreen to block UVA and UVB radiation. Bemotrizinol An ingredient used in sunscreen to block UVA and UVB radiation. Dioxybenzone A benzophenone derivative used in sunscreens to block UVB and short-wave UVA radiation. Diethylamino hydroxybenzoyl hexyl benzoate Indicated for use as a sunscreen agent. Glycol salicylate A salicylate used to treat mild to moderate muscle pain. Lufenuron Lufenuron is used in veterinary for the control of flea. Masitinib Masitinib is a tyrosine-kinase inhibitor used in the treatment of mast cell tumors in dogs. It has been available in Europe since 2009, under the brand name Masivet. In the... AZD-4877 AZD4877 has been used in trials studying the treatment of NHL, Tumors, Cancer, Lymphoma, and Neoplasms, among others. Mosapride A prokinetic 5-HT4 receptor agonist used to stimulate gastric motility. Adomeglivant Adomeglivant has been investigated for the basic science of Type 2 Diabetes. Vixotrigine Vixotrigine has been investigated for the treatment of Bipolar Disorder and Bipolar Depression. Navarixin Navarixin has been investigated for the treatment of Asthma. Momelotinib A Janus Kinase inhibitor used to treat intermediate or high-risk myelofibrosis. Danusertib Danusertib has been used in trials studying the treatment of Leukemia. Danegaptide Danegaptide has been investigated for the treatment of Focus of Study is STEMI. Mocetinostat Mocetinostat has been used in trials studying the treatment of Lymphoma, Urothelial Carcinoma, Relapsed and Refractory, Myelodysplastic Syndrome, and Metastatic Leiomyosarcoma, among others. Entinostat Entinostat is under investigation for the treatment and other of Volunteers, Breast Cancer, Human Volunteers, and Normal Volunteers. Entinostat has been investigated for the treatment of Non-Small Lung Cancer, Epigenetic... Flumatinib Flumatinib has been used in trials studying the treatment of Myelogenous Leukemia, Chronic. Vistusertib Vistusertib is under investigation for the treatment of Advanced Gastric Adenocarcinoma. Tasisulam Tasisulam has been used in trials studying the treatment and basic science of Melanoma, Lymphoma, Solid Tumors, Breast Cancer, and Ovarian Cancer, among others. Axelopran Axelopran has been used in trials studying the treatment of OIC and Opioid-induced Constipation. Tecovirimat An antiviral medication used to treat smallpox, monkeypox, and cowpox. CE-224535 CE-224535 has been used in trials studying the treatment of Osteoarthritis. Eplivanserin Eplivanserin has been used in trials studying the treatment of Sleep, Insomnia, Chronic Pain, Fibromyalgia, and Primary Insomnia, among others. VP-14637 MDT-637 has been investigated for the treatment of Drug Safety. N-6022 N6022 has been used in trials studying the treatment of Asthma and Cystic Fibrosis. Balicatib Balicatib has been used in trials studying the treatment of Osteoporosis and Knee Osteoarthritis. ABT-751 ABT-751 has been investigated for the treatment of Lung Cancer, Non-Small Cell Lung Cancer, and Non-Small-Cell Lung Cancer. Defactinib Defactinib has been investigated for the treatment of Malignant Pleural Mesothelioma. Darexaban Darexaban has been used in trials studying the prevention and basic science of Japanese, Caucasian, Thromboembolism, Pharmacodynamics, and Pharmacokinetics, among others. Tacedinaline Tacedinaline has been used in trials studying the treatment of Lung Cancer, Multiple Myeloma, and Pancreatic Cancer. Bavisant Bavisant has been used in trials studying the basic science and treatment of Alcoholism, Pharmacokinetics, Drug Interactions, Attention Deficit Hyperactivity Disorder, and Attention Deficit Disorders With Hyperactivity. ORG-25435 Org 25435 has been used in trials studying the treatment of Anaesthesia. Radotinib Radotinib is indicated for the treatment of different types of cancer, most notably Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML) with resistance or intolerance of other Bcr-Abl tyrosine-kinase inhibitors, such... LY-2456302 Ly2456302 has been used in trials studying the health services research and basic science of Anxiety Disorders and Alcohol Dependence. Betrixaban A Factor Xa inhibitor used for prophylaxis of venous thromboembolism in hospitalized patients. CI-1040 CI-1040 has been used in trials studying the treatment of Lung Cancer, Breast Cancer, Breast Neoplasms, Pancreatic Cancer, and Colorectal Cancer, among others. Lifibrol Lifibrol has been used in trials studying the basic science of Hyperlipoproteinemia and Hypercholesterolemia. Acotiamide Acotiamide has been used in trials studying the treatment of Dyspepsia and Functional Dyspepsia. BI-671800 Bi 671800 has been used in trials studying the treatment of Asthma and Rhinitis, Allergic, Perennial. MK-0686 MK0686 has been used in trials studying the treatment of Osteoarthritis, Pain, Postoperative, and Neuralgia, Postherpetic. AZD-9056 AZD9056 has been used in trials studying the basic science and treatment of Rheumatoid Arthritis. Etripamil Etripamil has been used in trials studying the treatment of Paroxysmal Supraventricular Tachycardia (PSVT). Emixustat Emixustat has been used in trials studying the treatment of Geographic Atrophy, Age-Related Macular Degeneration, and Dry Age-related Macular Degeneration. JNJ-41443532 JNJ-41443532 has been used in trials studying the basic science and treatment of Diabetes Mellitus, Type 2. Salirasib Salirasib has been used in trials studying the diagnostic of Carcinoma, Non-Small-Cell Lung. Mibampator Mibampator has been used in trials studying the treatment of Alzheimer's Disease. Boscalid Boscalid has been investigated for the treatment of OSDI, Glaucoma, Staining, Schirmers, and Disease Severity, among others. Relenopride Relenopride has been used in trials studying the treatment of Chronic Idiopathic Constipation. Tecarfarin Tecarfarin has been used in trials studying the prevention of Thrombosis and Thromboembolism. Etalocib Etalocib has been used in trials studying the treatment of Pancreatic Cancer, Carcinoma, Non-Small-Cell Lung, and Unspecified Adult Solid Tumor, Protocol Specific. DA-6886 DA-6886 has been used in trials studying the treatment of Irritable Bowel Syndrome. RO-4987655 RO4987655 has been used in trials studying the treatment of Neoplasms. Granotapide Granotapide has been used in trials studying the treatment of Type II Diabetes Mellitus. Acteoside Acteoside is under investigation in clinical trial NCT02662283 (Validity and Security of Reh-acteoside Therapy for Patients of IgA Nephropathy). LY-2300559 Ly2300559 has been used in trials studying the prevention of Migraine Headache. Tucaresol Tucaresol has been used in trials studying the treatment of HIV Infections. CEP-37440 CEP-37440 has been used in trials studying the treatment of Solid Tumors. Acoziborole SCYX-7158 has been used in trials studying the treatment of Trypanosomiasis, Parasitic Diseases, Protozoan Infections, and Trypanosomiasis, African. 4SC-202 4SC-202 has been used in trials studying the treatment of Advanced Hematologic Malignancies. Iobenzamic acid Not Annotated Clebopride A dopamine antagonist used to treat symptoms associated with functional gastrointestinal disorders. Clebopride may also be used to treat nausea and vomiting associated with chemotherapy. 4-dimethylaminophenol Not Annotated Morclofone Not Annotated Benorilate Not Annotated Anethole trithione A medication used to treat dry mouth associated with medication or radiotherapy of the head and neck. Nifuroxazide An antibiotic indicated in the treatment of susceptible gastrointestinal infections. Imidazole salicylate Not Annotated Iniparib Not Annotated Candesartan An angiotensin-receptor blocker indicated in the treatment of hypertension. Netarsudil A rho kinase inhibitor used to reduce intraocular pressure in patients with open angle glaucoma or ocular hypertension. SB-269970 SB-269970 is an experimental drug developed by GlaxoSmithKline. In the studies performed with this agent, it has been suggested that SB-269970 acts either as a selective antagonist or inverse agonist... Choline salicylate The oral gel is indicated for the relief of pain and discomfort of common mouth ulcers, cold sores, denture sore spots, infant teething and mouth ulcers, and sore spots due... Thiosalicylic acid Not Annotated Sacubitrilat A metabolite of LCZ696 with neprilysin inhibitory activity. p-Aminophenol Not Annotated Brovanexine Not Annotated Cavosonstat Cavosonstat is under investigation in clinical trial NCT02589236 (Study of Cavosonstat (N91115) in Patients With CF Homozygous for the F508del-CFTR Mutation). LGD-6972 LGD-6972 is under investigation in clinical trial NCT01919684 (Study to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of LGD-6972 in Healthy Subjects and Subjects With Type 2 Diabetes Mellitus). PF-05089771 PF-05089771 is under investigation in clinical trial NCT01529671 (A Safety And Tolerability Study Of PF-05089771 In Healthy Subjects And In Subjects With Otseoarthritis Of The Knee). TAS-116 TAS-116 is under investigation in clinical trial NCT02965885 (A Study of TAS-116 in Patients With Solid Tumors). Galicaftor Galicaftor is under investigation in clinical trial NCT03540524 (A Study Looking at the Safety, Tolerability and Efficacy of the Combination of the Study Drugs GLPG2451 and GLPG2222 With or Without... Selonsertib Selonsertib is under investigation in clinical trial NCT03053050 (Safety and Efficacy of Selonsertib in Adults With Nonalcoholic Steatohepatitis (NASH) and Bridging (F3) Fibrosis). GTX-758 GTX-758 is under investigation in clinical trial NCT01420861 (GTx-758 on Serum Prostate-specific Antigen (PSA) in Men With Castrate Resistant Prostate Cancer). Difamilast Difamilast is under investigation in clinical trial NCT01702181 (A Safety Study to Evaluate the Use and Effectiveness of a Topical Ointment to Treat Adults With Atopic Dermatitis). Fallypride Fallypride is under investigation in clinical trial NCT02310360 (Striatal and Extra-striatal Dopamine Release in Response to Food in Healthy Humans). ONO-8539 ONO-8539 is under investigation in clinical trial NCT01707901 (A Study of the Effect of ONO-8539 on Oesophageal Pain Hypersensitivity in Patients With Non-erosive Reflux Disease). Ampreloxetine Ampreloxetine is under investigation in clinical trial NCT03750552 (Clinical Effect of TD-9855 for Treating snOH in Subjects With Primary Autonomic Failure). Acebilustat Acebilustat is under investigation in clinical trial NCT01748838 (Phase 1 Study Assessing the Safety and Tolerability of CTX-4430). AZD-9977 AZD-9977 is under investigation in clinical trial NCT03843060 (A Phase 1 Study to Assess the Pharmacokinetics of AZD9977 Administered Alone and in Combination With Itraconazole in Healthy Volunteers). Giripladib Giripladib is under investigation in clinical trial NCT00396955 (A Study Comparing 4 Dose Regimens of PLA-695, Naproxen, and Placebo In Subjects With Osteoarthritis Of The Knee). Vidofludimus Vidofludimus is under investigation in clinical trial NCT03722576 (Vidofludimus Calcium for Primary Sclerosing Cholangitis). Acumapimod Acumapimod is under investigation in clinical trial NCT02926326 (The Effect of Azithromycin on BCT197 Exposure in Healthy Male Volunteers). Octyl triazone Not Annotated Ethyl salicylate A salicylate indicated in the treatment of sports related pain. JPC-3210 JPC-3210 is a potent antimalarial agent. It is an erythrocytic schizonticide with potent in vitro antimalarial activity against multidrug-resistant Plasmodium falciparum lines, low cytotoxicity, potent in vivo efficacy against murine... o-Cymen-5-ol Not Annotated Pitofenone A medication used in the treatment of spastic pain caused by menstrual cramps, the digestive system, and the urinary tract. Bicyclol Bicyclol is under investigation in clinical trial NCT02944552 (The Multi Center, Randomized, Double-blind, Positive Controlled Study of Bicyclol in the Treatment of Acute DILI). Bakuchiol Bakuchiol is under investigation in clinical trial NCT03112863 (Comparison of the Cosmetic Effects of Bakuchiol and Retinol). TAK-715 TAK-715 is under investigation in clinical trial NCT00760864 (Safety and Efficacy of TAK-715 in Subjects With Rheumatoid Arthritis). Cinaciguat Cinaciguat is under investigation in clinical trial NCT01067859 (A Phase Iib Study to Investigate the Efficacy and Tolerability of Lower Doses Cinaciguat (25 ÎœG/h, 10 ÎœG/h) Given Intravenously to Patients... Acetyldinaline Acetyldinaline is under investigation in clinical trial NCT00005624 (CI-994 in Treating Patients With Advanced Myeloma). Fenpyroximate Fenpyroximate is under investigation in clinical trial NCT02533336 (The Effectiveness of Non-pyrethroid Insecticide-treated Durable Wall Liners as a Method for Malaria Control in Endemic Rural Tanzania). CP-96345 Not Annotated Masoprocol Used for the treatment of actinic keratoses (precancerous skin growths that can become malignant if left untreated). Amphetamine A CNS stimulant and sympathomimetic agent indicated for the treatment of Attention Deficit Hyperactivity Disorder (ADHD). Aminosalicylic acid An aminosalicylate drug used to induce remission in ulcerative colitis. Diethylstilbestrol Used in the treatment of prostate cancer. Previously used in the prevention of miscarriage or premature delivery in pregnant women prone to miscarriage or premature delivery. Calcium acetate A phosphate binder used in patients with end-stage renal disease (ESRD) to prevent elevated phosphate levels and resulting ectopic calcification and secondary hyperparathyroidism. Crotamiton A topical scabicidal and antipruritic agent used for scabies eradication and for the relief of pruritus. Chlorotrianisene Used to treat symptoms of menopause, deficiencies in ovary function (including underdevelopment of female sexual characteristics and some types of infertility), and in rare cases, prostate cancer. Chlorotrianisene may also... Diatrizoate An injected contrast agent used in radiology. Chlorthalidone A diuretic used to treat hypertension or edema caused by heart failure, renal failure, hepatic cirrhosis, estrogen therapy, and other conditions. Aminohippuric acid A hippuric acid derivative injection utilized in the measurement of effective renal plasma flow (ERPF) and functional capacity of the renal excretory system. Nitisinone A hydroxyphenylpyruvate dioxygenase inhibitor used as an adjunct to dietary restrictions for the treatment of hereditary tyrosinemia type 1 (HT-1), which causes intolerance to tyrosine containing foods. Norepinephrine A sympathomimetic used in the control of blood pressure during various hypotensive states and as an adjunct treatment during cardiac arrest. Mexiletine A class 1B antiarrhythmic agent used in the treatment of documented ventricular arrhythmias that warrant treatment. Sorafenib A kinase inhibitor used to treat unresectable liver carcinoma, advanced renal carcinoma, and differentiated thyroid carcinoma. Chloramphenicol A broad spectrum antibiotic that is effective against a variety of susceptible and serious bacterial infections but is not frequently used because of its high risk of bone marrow toxicity. Bentiromide Indicated as a screening test for exocrine pancreatic insufficiency and to monitor the adequacy of supplemental pancreatic therapy. Monobenzone A hydroquinone derivative used to treat vitiligo. Cisapride A medication used to treat heartburn associated with GERD. Imatinib A tyrosine kinase inhibitor used to treat a number of leukemias, myelodysplastic/myeloproliferative disease, systemic mastocytosis, hypereosinophilic syndrome, dermatofibrosarcoma protuberans, and gastrointestinal stromal tumors. Clofibrate A fibric acid derivative used to treat hypertriglyceridemia and high cholesterol. Epinephrine A hormone and neurotransmitter used to treat allergic reactions, to restore cardiac rhythm, and to control mucosal congestion, glaucoma, and asthma. Modafinil A stimulant used to improve wakefulness in patients with sleep apnea, narcolepsy, or shift work disorder. Hexachlorophene A chlorinated bisphenol antiseptic used as a surgical scrub and skin cleanser. Orciprenaline A beta-2 adrenergic agonist used to treat bronchospasm, asthma, and COPD. Propofol A medication used in general anesthesia and for sedation. Dobutamine A beta-1 agonist used to treat cardiac decompensation in patients with organic heart disease or from cardiac surgery. Diflunisal An NSAID used to treat mild to moderate pain, inflammation, osteoarthritis, and rheumatoid arthritis. Clomifene A medication used to induce ovulation. Bumetanide A sulfamyl diuretic used to treat edema in congestive heart failure, hepatic and renal disease, and nephrotic syndrome. Dienestrol A non steroidal estrogen used to treat atrophic vaginitis and kraurosis vulvae. Oxybuprocaine A local anesthetic used in ophthalmology. Benzylpenicilloyl polylysine A penicillin derivative used to determine penicillin allergies. Meclofenamic acid An NSAID used to treat mild to moderate pain, primary dysmenorrhea, heavy menstrual blood loss, rheumatoid arthritis, and osteoarthritis. Dopamine A catecholamine neurotransmitter used to treat hemodynamic imbalances, poor perfusion of vital organs, low cardiac output, and hypotension. Balsalazide An aminosalicylate used to treat ulcerative colitis. Procainamide A medication used to treat life threatening ventricular arrhythmias. Tolterodine A muscarinic receptor antagonist used to treat overactive bladder with urinary incontinence, urgency, and frequency. Butenafine A topical antifungal used to treat tinea versicolor, tinea pedis, tinea cruris, and tinea corporis. Arbutamine Used to elicit acute cardiovascular responses (cardiac stumulant), similar to those produced by exercise, in order to aid in diagnosing the presence or absence of coronary artery disease (CAD) in... Phenacemide Used to control certain seizures in the treatment of epilepsy. Chloroprocaine A local anesthetic agent indicated for intrathecal injection in adults for the production of subarachnoid block, spinal anesthesia, or ocular surface anesthesia. Procarbazine An antineoplastic agent indicated for the treatment of stage III and stage IV Hodgkin's disease in combination with other chemotherapeutic agents. Moclobemide A monoamine oxidase inhibitor used in the treatment of major depressive disorder and bipolar disorder. Podofilox A topical agent used for the treatment of external genital warts and perianal warts. Iophendylate Iophendylate is used as a contrast agent to locate spinal tumors. Bromodiphenhydramine For management of symptoms related to hay fever and other types of allergy and used to help bring up phlegm, thin secretions, and make a cough productive. Iodixanol A contrast agent used during coronary angiography, particularly in patients with renal dysfunction. Fenoterol A beta-2 adrenergic agonist and bronchodilator used for the symptomatic treatment of asthma. Tolevamer A potassium-binding resin used in the treatment of hyperkalemia. Bezafibrate A lipid-lowering fibrate used in the management of primary and secondary hyperlipidaemia, when there is a lack of clinical improvement following lifestyle modifications or correction of the underlying disorder. Diethyltryptamine Diethyltryptamine (DET) is an orally active hallucinogenic agent and a substituted form of tryptamine. Embutramide Not Available Metrizamide Metrizamide is used for lumbar, thoracic, cervical, and total columnar myelography to determine the presence of abnormalities in the spinal column, spinal canal, and central nervous system (CNS) as well... Probucol Used to lower LDL and HDL cholesterol. Deferasirox An iron chelator used to treat chronic iron overload caused by blood transfusions. Also used in patients with non-transfusion-dependent thalassemia syndromes, and in patients with elevated liver iron concentration and serum ferritin. Pargyline For the treatment of moderate to severe hypertension. p-Hydroxymercuribenzoic acid Not Available Trinitrotoluene Trinitrotoluene is an explosive chemical that can cause skin irritation and other toxic consequences. P-Cresol Not Available 2,3,4,5,6-Pentafluorobenzyl Alcohol Not Available M-Cresol Not Available 4-Nitrocatechol sulfate Not Available Hyperforin Hyperforin is a phytochemical generated by the plants of the Hypericum family. One of the most important members of this family, due to its medical properties, is Hypericum perforatum, also... 3-Chlorophenol Not Available 3,5-Dinitrocatechol Not Available Vanillic acid A flavoring agent. It is the intermediate product in the two-step bioconversion of ferulic acid to vanillin. (J Biotechnol 1996;50(2-3):107-13). 1,2-Dihydroxybenzene Not Available Iodobenzene Not Available Flufenamic acid An analgesic drug used to relieve pain associated with rheumatoid diseases. Aminobenzoic acid A drug used to reduce the progression of penile deviation in Peyronie's Disease in adults. Benzylamine Not Available 1,3-Dinitrobenzene Not Available Resveratrol Being investigated for the treatment of Herpes labialis infections (cold sores). Compound 18 Not Available P-Anisic Acid Not Available Para-Bromobenzyl Alcohol Not Available IDD552 Not Available p-Iodophenol Not Available Doramapimod Doramapimod is a P38 MAP kinase inhibitor. 2-Aminobenzyl alcohol Not Available IC261 Not Available 2-Chlorophenol Not Available p-Toluenesulfonic acid Not Available Mant-Adp Not Available Phenol An antiseptic and disinfectant used in a variety of settings. 4-Nitrocatechol Not Available Acid yellow 54 free acid Not Available 4-Vinylguaiacol Not Available 3-hydroxyanthranilic acid An oxidation product of tryptophan metabolism. It may be a free radical scavenger and a carcinogen. Picric acid Used as antiseptic, astringent, and stimulant for epitheliazation. p-Chlorobenzoic acid Not Available Benzoic acid An antimicrobial food additive. 1,3,5-trichlorobenzene Not Available Coelenteramide Not Available 3,4-Xylenol Not Available 2-Nitro-4-cresol Not Available Anthranilic acid Not Available Matairesinol Not Available 4-Nitrophenyl Phosphate Not Available 4-hydroxybenzoic acid Not Available 6-hydroxydopa quinone Not Available P-Nitrophenol Not Available Afimoxifene For the potential treatment of menstrual-cycle related mastalgia, fibrocystic breast disease, breast disease, gynecomastia and Keloid scarring. Acedoben Not Available 2,4-Dinitrophenol A toxic dye, chemically related to trinitrophenol (picric acid), used in biochemical studies of oxidative processes where it uncouples oxidative phosphorylation. It is also used as a metabolic stimulant. (Stedman,... 2-Amino-4-methylphenol Not Available Niflumic acid A cyclooxygenase-2 inhibitor used to alleviate inflammation, pain, and edema associated with acute and chronic inflammatory conditions, such as rheumatoid arthritis, osteoarthritis, post-operative inflammatory conditions, and physical trauma. 2,5-di-tert-butylhydroquinone Not Available Iodipamide A contrast agent used in cholangiography and cholecystography. Bithionol Bithionol, formerly marketed as an active ingredient in various topical drug products, was shown to be a potent photosensitizer with the potential to cause serious skin disorders. Approvals of the... Phenolphthalein A drug used for symptomatic relief of constipation and bowel cleansing prior to medical procedures. Celiprolol A beta-blocker for the management of hypertension and angina pectoris. Merimepodib For the treatment of hepatitis C virus (HCV) infection. Dapoxetine A selective serotonin reuptake inhibitor used in the treatment of premature ejaculation. Ximelagatran For the treatment of acute deep vein thrombosis. Permethrin An insecticide used to prevent infestation with Sarcoptes scabiei (scabies). Ospemifene A non-hormonal estrogen receptor modulator (SERM) used to treat moderate to severe dyspareunia, a symptom of vulvar and vaginal atrophy, due to menopause. OXI-4503 Investigated for use/treatment in cancer/tumors (unspecified). Tarenflurbil Investigated for use/treatment in alzheimer's disease and prostate cancer. Chlorfenson Investigated for use/treatment in fungal infections. Succinobucol Investigated for use/treatment in atherosclerosis, coronary artery disease, diabetes mellitus type 2, and in-stent restenosis. VX-702 Investigated for use/treatment in coronary artery disease, inflammatory disorders (unspecified), and rheumatoid arthritis. AVN-944 Investigated for use/treatment in cancer/tumors (unspecified), leukemia (unspecified), lymphoma (unspecified), multiple myeloma, and pancreatic cancer. VX-765 Investigated for use/treatment in inflammatory disorders (unspecified) and psoriasis and psoriatic disorders. Iodofiltic acid I-123 Investigated for use/treatment in cardiac ischemia. GTS-21 Investigated for use/treatment in alzheimer's disease and schizophrenia and schizoaffective disorders. NS-3728 Investigated for use/treatment in anemia (sickle cell) and cancer/tumors (unspecified). Linifanib Investigated for use/treatment in leukemia (myeloid), myelodysplastic syndrome, and solid tumors. Tapinarof A therapeutic aryl hydrocarbon receptor-modulating agent (TAMA) indicated for the treatment of adult psoriasis. VX-148 Investigated for use/treatment in autoimmune diseases, psoriasis and psoriatic disorders, and viral infection. Cenobamate A small molecule drug indicated to treat partial onset seizures in adults. SNS-314 Investigated for use/treatment in solid tumors. Tapentadol An opioid used to manage severe pain that has not responded to non-opioid medications, and for which opioid analgesic therapy is appropriate. Caldaret Investigated for use/treatment in heart disease and myocardial infarction. Droxidopa A medication used to treat symptomatic neurogenic orthostatic hypotension (nOH) caused by dopamine beta-hydroxylase deficiency, non-diabetic autonomic neuropathy and primary autonomic failure caused by conditions such as Parkinson's disease. Senicapoc Investigated for use/treatment in anemia (sickle cell) and asthma. Glesatinib Investigated for use/treatment in cancer/tumors (unspecified). Armodafinil A stimulant used to improve wakefulness in adult patients with excessive sleepiness associated with obstructive sleep apnea, narcolepsy, or shift work disorder. Declopramide Investigated for use/treatment in colorectal cancer and inflammatory bowel disease. Ticalopride Investigated for use/treatment in gastroesophageal reflux disease (GERD) and gastroparesis. Dotarizine A calcium antagonist used to treat and prevent migraines. Etilevodopa Investigated for use/treatment in parkinson's disease. Axitinib An oral VEGFR and kinase inhibitor used for the treatment of advanced renal cell carcinoma after failure of one prior systemic therapy. Fispemifene Investigated for use/treatment in male hormonal deficiencies/abnormalities. Priralfinamide Investigated for use/treatment in pain (acute or chronic). Safinamide A MAO-B inhibitor used as an add-on treatment to levodopa/carbidopa for Parkinson's disease during "off" episodes. Fesoterodine An antimuscarinic agent used in the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and frequency. Iobenguane A radiopharmaceutical agent used for the diagnosis of primary and metastatic pheochromocytoma or neuroblastoma. Levonordefrin A topical sympathomimetic amine found in local anesthetic products that is used for nasal decongestion or vasoconstriction during dental procedures. Fospropofol A sedative-Âhypnotic agent indicated for monitored anesthesia care (MAC) sedation in adult patients undergoing diagnostic or therapeutic procedures. Enclomiphene Not Annotated Benzyl alcohol An antiparasitic agent used for the topical treatment of head lice infestation in patients 6 months of age and older. Capsaicin A topical analgesic agent used for the symptomatic relief of neuropathic pain associated with post-herpetic neuralgia, as well as other muscle and joint pain. Methenamine A urinary tract antiseptic and antibacterial drug used for the prophylaxis and treatment of frequently recurring urinary tract infections requiring a long-term therapy. Plerixafor A CXCR4 antagonist used in combination with granulocyte-colony stimulating factor to mobilize hematopoietic stem cells to the peripheral blood for collection and autologous transplantation in patients with non-Hodgkin’s lymphoma and multiple myeloma. Protokylol Protokylol is a β-adrenergic receptor agonist used as a bronchodilator in Europe and the United States. m-Hydroxyhippuric acid Not Available Acifluorfen Acifluorfen is a protoporphyrinogen oxidase inhibitor. Bromamphenicol Not Available Tranilast For the treatment of bronchial asthma, keloid and hypertrophic scar, and allergic disorders such as asthma, allergic rhinitis and atopic dermatitis. t-Butylhydroquinone Not Available Phloretin Phloretin is a natural dihydrochalcone found in apples and many other fruits. Hypothemycin Not Available Hexestrol A synthetic estrogen that has been used as a hormonal antineoplastic agent. Piceatannol Not Available Platensimycin Not Available 4-(ACETYLAMINO)-3-HYDROXY-5-NITROBENZOIC ACID Not Available Triclosan An antimicrobial agent in clinical setting for disinfection, and prevention of spread and growth of bacteria, fungus, and mildew. Thiamphenicol A semisynthetic derivative of chloramphenicol with a broad spectrum of antibacterial activity. Methyl vanillate Not Available 4-(Dimethylamino)benzoic acid Not Available Teriflunomide A pyrimidine synthesis inhibitor with anti-inflammatory and immunomodulatory properties used to treat patients with the relapsing-remitting form of multiple sclerosis. Regorafenib A kinase inhibitor used to treat patients with metastatic colorectal cancer, unresectable, locally advanced, or metastatic gastrointestinal stromal tumors, and hepatocellular carcinoma. Iotroxic acid Iotroxic acid is a contrast medium molecule. Iopanoic acid Iopanoic acid contains iodine and is useful as a contrast medium in cholecystography. Iopamidol A diagnostic imaging agent used for angiography throughout the cardiovascular system. Iodamide Iodamide is a contrast medium molecule that is no longer marketed in the United States. Indoramin Indoramin is a discontinued piperidine antiadrenergic drug with the trade names Baratol and Doralese. It is a selective alpha-1 adrenergic antagonist with no reflex tachycardia and direct myocardial depression action. Ibuproxam Ibuproxam is a non steroidal anti-inflammatory drug (NSAID). Glafenine An anthranilic acid derivative with analgesic properties used for the relief of all types of pain. Glafenine is withdrawn from the American market. Floctafenine An anti-inflammatory analgesic used to manage mild to moderate acute pain. Etofibrate Etofibrate is a fibrate produced by the combination of clofibrate ester linked to niacin. These components separate in the body slowly allowing for pharmacokinetics similar to controlled-release formulations. Etofenamate An NSAID used to treat muscle and joint pain. Bromopride A substituted benzamide, closely related to metoclopramide, used as an antiemetic. Ciprofibrate Not Annotated Lenvatinib A receptor tyrosine kinase inhibitor used for the treatment of metastatic thyroid cancer, advanced renal cell carcinoma in combination with everolimus, and unresectable hepatocellular carcinoma. Vilanterol A long-acting beta2-adrenergic agonist used in combination with other bronchodilators for the management of chronic obstructive pulmonary disease (COPD), including chronic bronchitis and/or emphysema. Tetracaine A local anaesthetic agent used to induce local analgesia in the eyes and skin during medical procedures. Eugenol A phenol used for the temporary relief of toothaches. Trimebutine A spasmolytic agent used for the symptomatic treatment of irritable bowel syndrome (IBS) and treatment of postoperative paralytic ileus following abdominal surgery. Zucapsaicin A topical analgesic used as an adjunct to relieve severe pain of osteoarthritis of the knee in selected adult patients. Iothalamic acid A diagnostic contrast agent used in various medical imaging procedures, such as angiography, arthrography, and computed tomographic scans. Ioversol A diagnostic contrast agent used in various medical imaging procedures, such as angiography, urography, and computed tomographic scans. Ioxilan A diagnostic contrast agent used in various medical imaging procedures, such as angiography, urography, and computed tomographic scans. Florbetaben F-18 A radiopharmaceutical diagnostic agent used during Positron Emission Tomography (PET) imaging of the brain to estimate β-amyloid neuritic plaque density in adult patients to diagnose the causes of cognitive impairment. Iopromide An X-ray contrast agent used during various types of imaging tests such as angiography and contrast computed tomography (CT) imaging tests. Tolfenamic acid In the information for tolfenamic acid, it is stated that this drug, being an NSAID, is effective in treating the pain associated with the acute attack of migraines in adults. Efonidipine For the treatment of hypertension. Manidipine A dihydropyridine calcium channel blocker used to treat hypertension. Caroxazone For the treatment of depression. Morniflumate An NSAID derived from niflumic acid used in the symptomatic treatment of inflammatory conditions of the airways, ENT, and the urogenital and osteoarticular systems. Ioxaglic acid A tri-iodinated benzoate contrast agent used in various radiological procedures including angiography, phlebography, urography, computed tomography (CT), and hysterosalpingography. Procaine benzylpenicillin A local anesthetic and antibiotic combination for intramuscular injection to treat a variety of bacterial infections while reducing pain from a deep intramuscular injection. Iopodic acid An iodine containing cholecystography agent. Tyropanoic acid For use in cholecystography (X-ray diagnosis/imaging of gallstones). Propoxycaine Propoxycaine is a local anesthetic medication. It was used beginning in the 1950s during dental procedures . It has been combined with procaine to accelerate its onset of action and... Metrizoic acid For use as a contrast medium . Acetrizoic acid Acetrizoic acid indication was to be used as a contrast agent for X-ray. Some information indicates its nephrotropic property as one of the characteristics for the utilization of acetrizoic acid.... Iocetamic acid Iocetamic acid is a diagnostic aid (radiopaque medium) Meglumine An amino sugar found in iodinated contrast media. Iotrolan Nonionic, isotonic contrast medium designed for intrathecal use. Hydroquinone A topical brightening agent used for the treatment of skin disorders associated with hyperpigmentation including melasma, post-inflammatory hyperpigmentation, sunspots, and freckles. Resorcinol Contemporary therapeutic uses for resorcinol primarily revolve around the use of the phenol derivative as an active ingredient in topical antiseptics [L2745, L2744, L40069, F61] or as topical antibacterial skin... Meradimate An ingredient used in sunscreens to absorb UV radiation. Chloroxylenol An antimicrobial used to treat cuts, bites, stings, abrasions, and used as an antiseptic hand cleaner. Racepinephrine A bronchodilator used to treat intermittent asthma. Cresol A dental disinfectant used to remove dental pulp. Butamben Anesthesia of mucus membranes other than the eyes. Phenyltoloxamine A medication used to treat minor aches and pains. Padimate A Padimate A is an ester derivative of PABA and an ingredient in some sunscreens. It absorbs ultraviolet rays thereby preventing sunburn, however, its chemical structure and behaviour is similar to... Hexylresorcinol An ingredient used to relieve irritation, pain, and prevent infection. Polydatin Polydatin, or Piceid, is a natural precursor and glycoside form of resveratrol with a monocrystalline structure. While it is isolated from the bark of Picea sitchensis or Polygonum cuspidatum, polydatin... Protocatechualdehyde Also known as protocatechuic aldehyde, protocatechualdehyde is a naturally-occuring phenolic aldehyde that is found in barley, green cavendish bananas, grapevine leaves and root of the herb S. miltiorrhiza . Protocatechualdehyde... Diethyltoluamide An insect repellant, also known as DEET. Nonivamide Nonivamide is used as a topical analgesic and is also used as a flavoring ingredient , , . Guaiacol It is used medicinally as an expectorant, antiseptic, and local anesthetic. Guaiacol is used in traditional dental pulp sedation, and has the property of inducing cell proliferation; guaiacol is a... Amitraz Amitraz is a non-systemic acaricide and insecticide. It was generated in 1969 by the Boots Co. in England. Amitraz presents insect repellent effects and hence, it can be used as... Dichlorophen Dichlorophen is an antimicrobial agent shown to exert activity against cestodes, protozoa, fungi, and bacteria. It is often combined with toluene to remove parasites including ascarids, tapeworm, and hookworm from... Florfenicol Florfenicol is a fluorinated synthetic analog of thiamphenicol. Maropitant Maropitant, used as maropitant citrate, is a neurokinin receptor antagonist, which was developed by Zoetis specifically for the treatment of motion sickness and vomiting in dogs. It was approved by... Nicarbazin Not Annotated Zeranol Zeranol is a non-steroidal estrogen agonist. It is a mycotoxin, derived from fungi in the Fusarium family, and may be found as a contaminant in fungus-infected crops. It is 3-4x... Zoalene Dinitolmide is a fodder additive for prophylaxis against coccidiosis infections in poultry. Butacaine Not Annotated Imidocarb Imidocarb is a urea derivative used in veterinary medicine as an antiprotozoal agent for the treatment of infection with Babesia and other parasites. Tricaine Tricaine (as tricaine methanesulfonate) is white powder used for anesthesia, sedation, or euthanasia of fish. It is also the only anesthetic licensed in the United States for use in fin... Padimate O An ingredient used in sunscreens to absorb UV radiation. Rabusertib Rabusertib has been used in trials studying the treatment of Cancer, Solid Tumors, Advanced Cancer, Pancreatic Neoplasms, and Non Small Cell Lung Cancer. Curcumin No approved therapeutic indications. Ilorasertib Ilorasertib has been used in trials studying the treatment of Myelodysplasia, Solid Neoplasm, Advanced Cancers, Advanced Solid Tumors, and Acute Myelogenous Leukemia, among others. Antineoplaston A10 Antineoplaston A10 has been used in trials studying the treatment of Sarcoma, Lymphoma, Lung Cancer, Liver Cancer, and Kidney Cancer, among others. Iomeprol An iodine-based X-ray contrast agent. AZD-5672 Azd5672 has been used in trials studying the basic science and treatment of Pharmacokinetics, Renal Impairment, and Rheumatoid Arthritis. PF-03882845 PF-03882845 has been used in trials studying the basic science of Diabetes Mellitus, Type 2 and Type 2 Diabetic Nephropathy. Tofogliflozin Tofogliflozin has been used in trials studying the treatment and prevention of Diabetes Mellitus Type 2. Dinitrochlorobenzene Dinitrochlorobenzene has been used in trials studying the treatment of HIV Infections. PF-00610355 PF-00610355 has been used in trials studying the treatment of Lung Disease, Moxifloxacin, Pulmonary Disease, Asthma, Bronchial, and Bronchial Diseases, among others. AUY922 AUY922 has been used in trials studying the treatment of Lymphoma, Breast Cancer, Metastatic Disease, Advanced Solid Tumors, and Hematologic Neoplasms, among others. Vestipitant Vestipitant has been investigated for the treatment of Tinnitus. Idalopirdine Idalopirdine has been used in trials studying the treatment of Cognition, Schizophrenia, and Alzheimer's Disease. Vanillyl alcohol Vanillyl alcohol has been used in trials studying the treatment of Smoking. Figopitant Figopitant is under investigation in clinical trial NCT02209714 (Safety, Tolerability and Pharmacodynamics After Oral Administration of BIIF 1149 BS in Healthy Male Volunteers). Elubrixin Elubrixin has been used in trials studying the treatment of Cystic Fibrosis, Colitis, Ulcerative, and Chronic Obstructive Pulmonary Disease (COPD). HX-1171 Hx 1171 is under investigation in clinical trial NCT01548391 (A Phase I Clinical Study Study of the Safety, Tolerability, and Pharmacokinetics of HX-1171 in Healthy Male Subjects). Secoisolariciresinol Secoisolariciresinol has been used in trials studying the prevention of Breast Cancer. Terameprocol Terameprocol has been investigated for the treatment of Brain and Central Nervous System Tumors. Dopexamine Dopexamine has been used in trials studying the diagnostic and treatment of Free Flap, Oral Cancer, Hypotension, Septic Shock, and Head and Neck Cancer. Idasanutlin Idasanutlin has been used in trials studying the treatment of Neoplasms, Non-Hodgkin's Lymphoma, Leukemia, Myeloid, Acute, Recurrent Plasma Cell Myeloma, and Neoplasms, Leukemia, Acute Myeloid Leukemia. Netazepide Netazepide has been used in trials studying the prevention and treatment of Dyspepsia, Hypergastrinaemia, Barrett's Esophagus, ECL-cell Hyperplasia, and Rebound Hyperacidity, among others. Iobitridol An iodine-based contrast agent used with X-ray or CT imaging. Ioforminol Ioforminol has been used in trials studying the diagnostic of Cardio Renal Safety in High-risk Elderly Subjects Undergoing a Coronary CATH With or Without PCI. Nitroaspirin Nitroaspirin has been investigated for the treatment of Intermittent Claudication. Propyl Gallate Propyl Gallate is under investigation in clinical trial NCT01450098 (A Study of LY2484595 in Healthy Subjects). Raclopride Raclopride has been used in trials studying Parkinson Disease. Nelotanserin Nelotanserin has been used in trials studying the treatment of Lewy Body Dementia, Visual Hallucinations, Dementia With Lewy Bodies, and REM Sleep Behavior Disorder. It is a highly selective antagonist... LY-295501 ILX-295501 has been used in trials studying the treatment of Ovarian Cancer, Metastatic Cancer, Fallopian Tube Cancer, and Primary Peritoneal Cavity Cancer. Fosbretabulin Fosbretabulin has been investigated for the treatment of Anaplastic Thyroid Cancer. Ondelopran Ondelopran has been used in trials studying the treatment of Alcohol Dependence. Combretastatin Combretastatin has been investigated for the treatment of Anaplastic Thyroid Cancer. CGI-1842 JI-101 has been used in trials studying the treatment of Cancer, Colon Cancer, Neuroendocrine, Ovarian Cancer, and Advanced Solid Tumors. CHF-6001 CHF6001 has been used in trials studying the treatment of Asthma and Chronic Obstructive Pulmonary Disease. Picropodophyllin Picropodophyllin has been investigated for the treatment of Non Small Cell Lung Cancer. Dichloroisoproterenol Dichloroisoproterenol has been used in trials studying the treatment and basic science of Insulin Resistance and Polycystic Ovary Syndrome. Ataciguat Ataciguat has been investigated for the basic science of Aortic Valve Stenosis. Tetrasul Tetrasul has been used in trials studying the treatment of Erythematous (Type One) Rosacea. Reproterol A short-acting β2 adrenoreceptor agonist used to treat various types of asthma including allergic asthma, non-allergic asthma, and exercise-induced asthma. Quizartinib A FLT3 inhibitor used in combination with cytarabine and anthracycline to treat acute myeloid leukemia with FLT3 internal tandem duplication Theodrenaline Theodrenaline is under investigation in clinical trial NCT01311414 (Effect of Cafedrine/Theodrenaline and Urapidil on Cerebral Oxygenation). Phloroglucinol A spasmolytic agent to treat colic, as well as spastic pain of the digestive and biliary tracts. Tiapride A dopamine D2 and D3 receptor antagonist indicated in the treatment of chorea in Huntington's disease, as well as agitation and anxiety in the elderly or with acute or chronic alcoholism. Aminaphthone A medication that inhibits erythrocyte aggregation in capillaries, improving venous return for the treatment of capillary fragility. GDC-0349 GDC-0349 has been used in trials studying the treatment of Non-Hodgkin's Lymphoma, Solid Tumor. Parachlorophenol An antibacterial agent used to prevent infections in root canals. Teclozan An antiprotozoal agent indicated in the treatment of intestinal amebiasis. Phenolsulfonphthalein Phenolsulfonphthalein or otherwise called phenol red is a pH indicator commonly used in cell biology laboratories. Phenolsulfonphthalein is being investigated for use clinically due to its weak estrogen mimicking actions... Sulfobromophthalein Sulfobromophthalein or otherwise called bromsulphthalein is used as a test of liver function in humans . Stibophen Stibophen is used in the treatment of schistosomiasis, a disease of parasitic flatworms. Clofoctol An antibacterial agent indicated in the treatment of respiratory infections; or prevention of infections after ear, nose, and throat surgery. Hexobendine Hexobendine is a medication used to cause vasodilation, to treat several conditions including angina pectoris. It has not been approved in the United States or the United Kingdom, but has... Dichlorobenzyl alcohol A medication used to treat a sore throat. Wood creosote Not Annotated Sultopride Sultopride is used in Japan, Hong Kong, and Europe to treat schizophrenia. It is of the drug class atypical antipsychotics . Bucetin Bucetin is an analgesic and antipyretic medication which was approved for use in Germany but was withdrawn from the market in 1986 due to renal toxicity caused by the medication. Azidamfenicol Not Annotated Tolpropamine Not Annotated Benproperine An antitussive indicated in the treatment of acute and dry cough, especially dry cough. Melevodopa A methyl ester of levodopa indicated in combination with carbidopa for the treatment of Parkinson's disease. Ibopamine A sympathomimetic, indicated in the induction of mydriasis and treatment of pos-surgical ocular hypotonia. Bufexamac An NSAID used to treat skin conditions like atopic eczema and inflammatory dermatoses. Adrenalone Not Annotated Simfibrate Not Annotated Fenpiprane Not Annotated Ioxitalamic acid A contrast agent used for CT scans of the abdomen and pelvis. Cyclofenil Not Annotated Etamsylate A hemostatic agent that acts by restoring capillary resistance and improving platelet adhesion. Policresulen Not Annotated Aloxiprin Not Annotated Clefamide Not Annotated Veralipride Not Annotated Dobesilic acid A medication indicated in the treatment of hemorrhoids, venous insufficiency, and other microangiopathies. Guacetisal Not Annotated Iodoxamic acid Radiopaque medium used in the diagnosis of gall bladder & bile duct diseases, usually as meglumine salt. Bifemelane Not Annotated Rimiterol Not Annotated Carbaspirin calcium An NSAID indicated in the treatment of short term pain and fever. Melagatran Not Annotated Ethyl hydroxybenzoate Not Annotated Lorcainide Not Annotated Ioglicic acid Not Annotated Quifenadine Not Annotated Potassium guaiacolsulfonate A mucolytic and expectorant indicated to relieve a productive cough. Ioglycamic acid Not Annotated Iocarmic acid Not Annotated Epanolol Epanolol is an beta blocker. Reposal Reposal is a barbiturate derivative invented in the 1960s in Denmark that has sedative, hypnotic and anticonvulsant properties. It was used primarily in the treatment of insomnia. Bibrocathol Not Annotated Clofibride Not Annotated Iopentol Iopentol is used as a contrast medium. Hemoglobin crosfumaril Hemoglobin in which the alpha-subunit are cross-linked intramolecularly. 2-Methoxy-6-{(E)-[(4-methylphenyl)imino]methyl}phenol TIMBD is an azaresveratrol analog. Fenofibric acid A fibrate used to treat severe hypertriglyceridemia, primary hypercholesterolemia, or mixed dyslipidemia. Amylmetacresol An antiseptic used to treat infections in the mouth and throat. Bismuth subgallate A medication used to deodorize flatulence and stools as well as hemostasis in soft tissue surgery. Deoxyepinephrine Sympathomimetic, vasoconstrictor agent. Diclofop-methyl Herbicide for control of wild oat & foxtails in cereal crops. J147 J147 is an experimental drug with reported effects against both Alzheimer's disease and ageing in mouse models of accelerated aging. [A31606,A31607,A31608] It is a curcumin derivative and a potent neurogenic... 1,2-dichlorobenzene 1,2-Dichlorobenzene, also named ortho-dichlorobenzene, is an organic compound. It is a non-polar colorless liquid that is miscible in most organic solvents. This derivative of benzene differs from the parent compound... NS-398 NS-398 is a COX-2 inhibitor. It was developed as part of the mechanistic study of the cyclooxygenases. Bisphenol A diglycidyl ether Not Annotated Butylparaben Not Annotated Phenylethyl resorcinol A tyrosinase inhibitor with skin-lightening activity. Macelignan Macelignan is an NSAID with antioxidant, free radical scavenging, and neuroprotective activities. Benzylparaben Benzylparaben is used in allergenic testing. Propylparaben Propylparaben is used in allergenic testing. Isoeugenol Isoeugenol is approved by the FDA for use within allergenic epicutaneous patch tests which are indicated for use as an aid in the diagnosis of allergic contact dermatitis (ACD) in... Methylparaben Methylparaben is used in allergenic testing. Deacetylbisacodyl Not Annotated Chloramphenicol palmitate Not Annotated Dienestrol diacetate Not Annotated Combretastatin A4 Not Annotated Tosylchloramide A chlorinated disinfectant of the genitals and injured skin. Hydroxystilbamidine Used in the treatment of nonprogressive blastomycosis of the skin and other mycoses. 2-(aminomethyl)phenol 2-(aminomethyl)phenol is under investigation in clinical trial NCT03556319 (2-HOBA: Multiple Dosing Study in Older Adults). Mavacamten A myosin inhibitor used to treat obstructive hypertrophic cardiomyopathy. Elsulfavirine Elsulfavirine is under investigation in clinical trial NCT03706898 (Study to Evaluate the Safety and PK of Elpida® in Healthy Subjects and Patients With Hepatic Impairment and to Assess the Impact... Flurbiprofen axetil Flurbiprofen axetil is under investigation in clinical trial NCT02043366 (Effect of Butorphanol Combined With Flurbiprofen Axetil on Preventing Hyperalgesia Induced by Remifentanil in Patients). AZD-6482 AZD-6482 is under investigation in clinical trial NCT00688714 (Study to Investigate Safety and Tolerability of a Single Dose of AZD6482). Flufenoxuron Flufenoxuron is under investigation in clinical trial NCT00922870 (Evaluation of Hemodynamic Effects of Cascade Hemofiltration in Septic Shock). Agerafenib Agerafenib is under investigation in clinical trial NCT03052569 (Expanded Access to RXDX-105 for Cancers With RET Alterations). Somapacitan A human growth hormone analog subcutaneous injection indicated for adults with growth hormone deficiency. Transfluthrin Transfluthrin is under investigation in clinical trial NCT02394522 (Spatial Repellent Products for Control of Vector Borne Diseases - Malaria - Zambia (SR-M-ZM)). Telaglenastat Telaglenastat is under investigation in clinical trial NCT02071862 (Study of the Glutaminase Inhibitor CB-839 in Solid Tumors). Dihydrocapsiate Dihydrocapsiate is under investigation in clinical trial NCT00999297 (Effect of 4-week Dihydrocapsiate Ingestion on Resting Metabolic Rate). Iodohippuric acid Iodohippuric acid is under investigation in clinical trial NCT02599844 (Impact of Pediatric Acute Renal Injury in Severe Sepsis in Young Adults). Resorcinol monoacetate Not Annotated Fluazuron Fluazuron is a benzoyl phenylurea compound. Zingerone Zingerone is a pungent component of ginger. Aminopentamide Not Annotated Droloxifene Droloxifene, a derivative of the triphenylethylene drug tamoxifen, is a novel selective estrogen receptor modulator (SERM). Droloxifene also exhibits more rapid pharmacokinetics, reaching peak concentrations and being eliminated much more... 1,3,5-Trimethoxybenzene A medication indicated for the symptomatic treatment of spastic pain of the urinary tract, renal colic, and painful disorders of the digestive and biliary tract. Carvasept A medication used to treat hemorrhoids, anal fissures, and pruritus ani. Levosulpiride indicated to treat dyspepsia, symptoms of Meniere's syndrome, and second line in the treatment of drug-induced nausea and vomiting. VLX-1570 VLX-1570 is under investigation in clinical trial NCT02372240 (A Study of VLX1570 and Dexamethasone in Myeloma Patients). Batabulin Batabulin is under investigation in clinical trial NCT00057382 (T138067 Versus Doxorubicin in Chemotherapy-naive, Unresectable, Hepatocellular Carcinoma Patients). Dopastatin Dopastatin is under investigation in clinical trial NCT04335357 (TBR-760 in Adult Patients With Non-functioning Pituitary Adenomas). Olodanrigan Olodanrigan is under investigation in clinical trial NCT03297294 (Safety and Efficacy of EMA401 in Patients With Painful Diabetic Neuropathy (PDN)). Xevinapant Not Annotated Volinanserin Volinanserin is under investigation in clinical trial NCT00464243 (Efficacy and Safety of Volinanserin on Sleep Maintenance Insomnia - Polysomnographic Study). Carvacrol Not Annotated Thyme oil Not Annotated Palovarotene A selective agonist of retinoic acid receptor gamma (RARγ) used to reduce heterotopic ossification in patients with Fibrodysplasia Ossificans Progressiva (FOP). Lavendustin b Not Annotated Tyrphostin B44 Not Annotated WZB-117 Not Annotated Lavendustin A Not Annotated Tyrphostin AG 555 Not Annotated Tyrphostin B48 Not Annotated Tyrphostin B56 Not Annotated Tyrphostin AG 879 Not Annotated Itanapraced Not Annotated Hippuric acid Not Annotated BMS-833923 Not Annotated Butylated hydroxytoluene Not Annotated Chlorocresol Not Annotated Rosmarinic acid Not Annotated Arctigenin Not Annotated S-38093 Not Annotated Z-160 Z160 has been used in trials studying the treatment of Postherpetic Neuralgia and Lumbosacral Radiculopathy. ASC-JM-17 Not Annotated RG-2833 Not Annotated ABT-737 An inhibitor of members of the Bcl‑2 family of apoptosis regulators. JTC-801 free base An antagonist of nociceptin receptor and analgesic agent, evaluated for its use in cancer treatment. N-oleoyldopamine N-oleoyldopamine (OLDA) is an amide of dopamine and oleic acid. Iopofosine I-131 Iopofosine I-131 (NM-404 I-131) is under investigation in clinical trial NCT01495663 (Dose Escalation Study of I-131-CLR1404 in Subjects With Cancer That Does Not Respond to Treatment or Has Returned). NRC-AN-019 Not Annotated Abequolixron Not Annotated Disufenton Not Annotated p-Toluenesulfonamide Not Available Bexagliflozin A sodium-glucose co-transporter 2 inhibitor used to improve glycemic control in patients with type 2 diabetes mellitus. Domatinostat Not Annotated GSK-2879552 Not Annotated Darapladib Investigated for use/treatment in atherosclerosis. Netupitant An antiemetic agent used in combination with palonosetron to prevent acute and delayed vomiting and nausea caused by chemotherapy. Tannic acid Tannic acid is indicated for cold sores, fever blisters, diaper rash, minor burn or sunburn and prickly heat. Vaginally, tannic acid is used as a douche for leukorrhea. It has... Avoralstat Avoralstat has been used in trials studying the prevention of HAE and Hereditary Angioedema. Fosdagrocorat Fosdagrocorat has been used in trials studying the treatment and basic science of Rheumatoid Arthritis. PCI-27483 PCI-27483 has been used in trials studying the treatment of Pancreatic Cancer, Ductal Adrenocarcinoma, and Exocrine Pancreatic Cancer. Fagrocorat Not Annotated Remetinostat Remetinostat is under investigation in clinical trial NCT02213861 (Efficacy, Safety and Tolerability Study of SHAPE in IA, IB or IIA Cutaneous T-cell Lymphoma). HQP1351 HQP1351 is under investigation in clinical trial NCT03883100 (A Pivotal Study of HQP1351 in Patients of Chronic Myeloid Leukemia in Accelerated Phase With T315I Mutation). Mesdopetam Mesdopetam is under investigation in clinical trial NCT04435431 (A Clinical Study of Mesdopetam in Patients With Parkinson's Disease Experiencing Levodopa Induced Dyskinesia). Runcaciguat Not Annotated MK-886 MK-886 is an experimental inhibitor of leukotriene synthesis. Glycerol Tribenzoate Not Annotated Acecainide Acecainide is an investigational anti-arrhythmia drug. Pocapavir Not Annotated K-777 Not Annotated WP-1066 WP1066 has been used in trials studying the treatment of Melanoma, Brain Cancer, Solid Tumors, and Central Nervous System Neoplasms. Nevanimibe Nevanimibe is under investigation in clinical trial NCT03053271 (A Study of ATR-101 for the Treatment of Endogenous Cushing's Syndrome). Pterostilbene Not Annotated Acoramidis Not Annotated Docarpamine Not Available Lisaftoclax Lisaftoclax is a novel, orally active, selective and potent BCL-2 inhibitor AGS-499 Not Annotated Encaleret Not Available Fipaxalparant Not Annotated Flumecinol Not Annotated Indralin Not Annotated Zapnometinib Not Annotated MEDI-547 MEDI-547 is an anti-EphA1 monoclonal antibody conjugated to mcMMAF Crisdesalazine Not Annotated ABSK-091 Not Annotated - Drugs & Drug Targets