- Name
- Phosphodiesterase 3 Inhibitors
- Accession Number
- DBCAT000590
- Description
Compounds that specifically inhibit PHOSPHODIESTERASE 3.
- Drugs
| Drug | Drug Description |
|---|
| Amrinone | A positive inotropic agent and phosphodiesterase inhibitor used in the management of treatment of congestive heart failure. |
| Anagrelide | A platelet-reducing agent used to treat thrombocythemia, and its related complications, secondary to myeloproliferative neoplasms. |
| Cilostazol | An antiplatelet agent and vasodilator used for the symptomatic relief of intermittent claudication. |
| Enoximone | A selective phosphodiesterase inhibitor indicated in the short term treatment of congestive heart failure. |
| Ensifentrine | A phosphodiesterase inhibitor used for the maintenance treatment of chronic obstructive pulmonary disease (COPD) in adults. |
| Levosimendan | A calcium sensitizer indicated to treat acutely decompensated severe chronic heart failure. |
| Milrinone | A PDE-III inhibitor with inotropic, lusitropic, and vasodilatory properties used for the short-term treatment of acute decompensated heart failure. |
| Olprinone | Not Annotated |
| Simendan | Not Annotated |
- Drugs & Drug Targets
| Drug | Target | Type |
|---|
| Amrinone | Tumor necrosis factor | target |
| Amrinone | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A | target |
| Amrinone | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B | target |
| Amrinone | cAMP-specific 3',5'-cyclic phosphodiesterase 4 (PDE4) | target |
| Anagrelide | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A | target |
| Anagrelide | Cytochrome P450 1A2 | enzyme |
| Anagrelide | Phosphodiesterase 3 | target |
| Cilostazol | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A | target |
| Cilostazol | Cytochrome P450 2C19 | enzyme |
| Cilostazol | Cytochrome P450 3A4 | enzyme |
| Cilostazol | Cytochrome P450 3A5 | enzyme |
| Cilostazol | Cytochrome P450 3A7 | enzyme |
| Cilostazol | Cytochrome P450 1A2 | enzyme |
| Cilostazol | Cytochrome P450 2D6 | enzyme |
| Enoximone | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A | target |
| Enoximone | Phosphodiesterase 3 | target |
| Ensifentrine | Cytochrome P450 2C9 | enzyme |
| Ensifentrine | Cytochrome P450 2D6 | enzyme |
| Ensifentrine | Phosphodiesterase 3 | target |
| Ensifentrine | Phosphodiesterase 4 | target |
| Ensifentrine | Broad substrate specificity ATP-binding cassette transporter ABCG2 | transporter |
| Levosimendan | Troponin C, slow skeletal and cardiac muscles | target |
| Levosimendan | ATP-sensitive inward rectifier potassium channel 11 | target |
| Levosimendan | ATP-sensitive inward rectifier potassium channel 8 | target |
| Levosimendan | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A | target |
| Levosimendan | Phosphodiesterase 3 | target |
| Milrinone | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A | target |
| Olprinone | Phosphodiesterase 3 | target |
| Olprinone | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A | target |