Phosphodiesterase 3 Inhibitors

Name
Phosphodiesterase 3 Inhibitors
Accession Number
DBCAT000590
Description

Compounds that specifically inhibit PHOSPHODIESTERASE 3.

Drugs
DrugDrug Description
MilrinoneA PDE-III inhibitor with inotropic, lusitropic, and vasodilatory properties used for the short-term treatment of acute decompensated heart failure.
CilostazolAn antiplatelet agent and vasodilator used for the symptomatic relief of intermittent claudication.
AmrinoneA positive inotropic agent and phosphodiesterase inhibitor used in the management of treatment of congestive heart failure.
EnoximoneA selective phosphodiesterase inhibitor indicated in the short term treatment of congestive heart failure.
AnagrelideA platelet-reducing agent used to treat thrombocythemia, and its related complications, secondary to myeloproliferative neoplasms.
LevosimendanA calcium sensitizer indicated to treat acutely decompensated severe chronic heart failure.
SimendanSimendan is under investigation in clinical trial NCT00527059 (Renal Effects of Levosimendan in Patients Admitted With Acute Decompensated Heart Failure).
OlprinoneNot Annotated
Drugs & Drug Targets
DrugTargetType
MilrinonecGMP-inhibited 3',5'-cyclic phosphodiesterase Atarget
CilostazolcGMP-inhibited 3',5'-cyclic phosphodiesterase Atarget
CilostazolCytochrome P450 2C19enzyme
CilostazolCytochrome P450 3A4enzyme
CilostazolCytochrome P450 3A5enzyme
CilostazolCytochrome P450 3A7enzyme
CilostazolCytochrome P450 1A2enzyme
CilostazolCytochrome P450 2D6enzyme
AmrinoneTumor necrosis factortarget
AmrinonecGMP-inhibited 3',5'-cyclic phosphodiesterase Atarget
AmrinonecGMP-inhibited 3',5'-cyclic phosphodiesterase Btarget
AmrinonecAMP-specific 3',5'-cyclic phosphodiesterase 4 (PDE4)target
AmrinonecAMP-specific 3',5'-cyclic phosphodiesterase 3target
EnoximonecGMP-inhibited 3',5'-cyclic phosphodiesterase Atarget
AnagrelidecGMP-inhibited 3',5'-cyclic phosphodiesterase Atarget
AnagrelideCytochrome P450 1A2enzyme
LevosimendanTroponin C, slow skeletal and cardiac musclestarget
LevosimendanATP-sensitive inward rectifier potassium channel 11target
LevosimendanATP-sensitive inward rectifier potassium channel 8target
LevosimendancGMP-inhibited 3',5'-cyclic phosphodiesterase Atarget