- Phosphodiesterase Inhibitors
- Accession Number
Compounds which inhibit or antagonize the biosynthesis or actions of phosphodiesterases.
- ATC Classification
Drug Drug Description Milrinone An inotropic vasodilator agent used to treat acute, decompensated heart failure. Amrinone A positive inotropic agent and phosphodiesterase inhibitor used in the management of treatment of congestive heart failure. Enoximone For the treatment of congestive heart failure. Tadalafil A phosphodiesterase 5 inhibitor used to treat erectile dysfunction, benign prostatic hyperplasia, and pulmonary arterial hypertension. Vardenafil A phosphodiesterase 5 inhibitor used to treat erectile dysfunction. Cilostazol An antiplatelet agent and vasodilator used for the symptomatic relief of intermittent claudication. Piclamilast Piclamilast (RP-73,401), is a selective PDE4 inhibitor comparable to other PDE4 inhibitors for its anti-inflammatory effects. It has been investigated for its applications to the treatment of conditions such as... Rolipram A phosphodiesterase inhibitor with antidepressant properties. OSI-461 Investigated for use/treatment in crohn's disease, inflammatory bowel disease, kidney cancer, leukemia (lymphoid), and prostate cancer. Udenafil Investigated for use/treatment in erectile dysfunction and hypertension. 3-isobutyl-1-methyl-7H-xanthine Not Available Doxofylline Indicated for the treatment of chronic obstructive pulmonary disease (COPD), bronchial asthma and pulmonary disease with spastic bronchial component. Trapidil Used in the treatment of chronic stable angina . Pimobendan Not Annotated Mirodenafil Mirodenafil has been used in trials studying the treatment and supportive care of Kidney Diseases, Urologic Diseases, Renal Insufficiency, Erectile Dysfunction, and Male Erectile Dysfunction. PF-04447943 PF-04447943 has been investigated for the treatment of Alzheimer's Disease. Vesnarinone Vesnarinone has been used in trials studying the treatment of HIV Infections and Sarcoma, Kaposi. Vinpocetine Vinpocetine has been investigated for the treatment of Epilepsy. GSK-256066 Gsk256066 has been used in trials studying the treatment and diagnostic of SAR, Asthma, Mild Asthma, Allergic Rhinitis, and Seasonal Allergic Rhinitis, among others. Simendan Simendan is under investigation in clinical trial NCT00527059 (Renal Effects of Levosimendan in Patients Admitted With Acute Decompensated Heart Failure). MK-0873 MK-0873 has been used in trials studying the treatment of Rheumatoid Arthritis. Bucladesine Not Annotated Roflumilast A selective phosphodiesterase 4 inhibitor indicated to decrease the risk of exacerbations in patients with severe chronic obstructive pulmonary disease (COPD) associated with a history of exacerbations and chronic bronchitis. E-6005 E6005 has been used in trials studying the treatment of Atopic Dermatitis. Caffeine A stimulant present in tea, coffee, cola beverages, analgesic drugs, and agents used to increase alertness. It is also used in to prevent and treat pulmonary complications of premature birth. Theophylline A xanthine used to manage the symptoms of asthma, COPD, and other lung conditions caused by reversible airflow obstruction. Dyphylline A theophylline derivative used to treat asthma, bronchospasm, and COPD. Pentoxifylline A methylxanthine derivative used to treat intermittent claudication caused by chronic occlusive arterial disease of the limbs. Levosimendan For short term treatment of acutely decompensated severe chronic heart failure (CHF). Also being investigated for use/treatment in heart disease. Dipyridamole A phosphodiesterase inhibitor used to prevent postoperative thromboembolic events. Papaverine An alkaloid used to treat many types of smooth muscle spasms such as "vascular spasms" associated with acute myocardial infarction and angina pectoris, as well as "visceral spasms". Aminophylline A bronchodilator consisting of theophylline that is used for the treatment of bronchospasm due to asthma, emphysema and chronic bronchitis. Cilomilast Investigated for use/treatment in chronic obstructive pulmonary disease (COPD). Ibudilast For the treatment of multiple sclerosis, asthma, and cerebrovascular disease. Anagrelide A platelet-reducing agent used to treat thrombocythemia, and its related complications, secondary to myeloproliferative neoplasms. Crisaborole A non-steroidal topical medication used for the treatment of mild-moderate atopic dermatitis. Zardaverine Not Available Apremilast A non-steroidal medication used for the treatment of inflammatory conditions such as psoriasis and psoriatic arthritis.
- Drugs & Drug Targets