Phosphodiesterase Inhibitors
- Name
- Phosphodiesterase Inhibitors
- Accession Number
- DBCAT000509
- Description
Compounds which inhibit or antagonize the biosynthesis or actions of phosphodiesterases.
- ATC Classification
- Drugs
Drug Drug Description 3-isobutyl-1-methyl-7H-xanthine Not Available Aminophylline A bronchodilator consisting of theophylline that is used for the treatment of bronchospasm due to asthma, emphysema and chronic bronchitis. Amrinone A positive inotropic agent and phosphodiesterase inhibitor used in the management of treatment of congestive heart failure. Anagrelide A platelet-reducing agent used to treat thrombocythemia, and its related complications, secondary to myeloproliferative neoplasms. Apremilast A non-steroidal medication used for the treatment of inflammatory conditions such as psoriasis and psoriatic arthritis. Avanafil A phosphodiesterase-5 (PDE5) inhibitor used to treat erectile dysfunction. Bucladesine Not Annotated Caffeine A stimulant present in tea, coffee, cola beverages, analgesic drugs, and agents used to increase alertness. It is also used in to prevent and treat pulmonary complications of premature birth. Cilomilast Investigated for use/treatment in chronic obstructive pulmonary disease (COPD). Cilostamide Cilostamide is a small molecule drug. Cilostamide has a monoisotopic molecular weight of 342.19 Da. Cilostazol An antiplatelet agent and vasodilator used for the symptomatic relief of intermittent claudication. Cipamfylline Cipamfylline is a small molecule drug. The usage of the INN stem '-fylline' in the name indicates that Cipamfylline is a N-methylated xanthine derivative. Cipamfylline has a monoisotopic molecular weight... Crisaborole A non-steroidal topical medication used for the treatment of mild-moderate atopic dermatitis. Denbufylline Denbufylline is a small molecule drug. The usage of the INN stem '-fylline' in the name indicates that Denbufylline is a N-methylated xanthine derivative. Denbufylline has a monoisotopic molecular weight... Difamilast A phosphodiesterase-4 inhibitor used for the treatment of atopic dermatitis. Dipyridamole A phosphodiesterase inhibitor used to prevent postoperative thromboembolic events. Dovramilast Dovramilast is under investigation in clinical trial NCT01300208 (To Evaluate the Preliminary Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Efficacy of CC-11050 in Subjects With Discoid Lupus Erythematosus and Subacute Cutaneous Lupus... Doxofylline A methylxanthine derivative used in chronic obstructive pulmonary disease, asthma, and bronchospasms. Drotaverine A phosphodiesterase-4 inhibitor used to alleviate gastrointestinal and genitourinary smooth muscle spasms. Dyphylline A theophylline derivative used to treat asthma, bronchospasm, and COPD. Enoximone A selective phosphodiesterase inhibitor indicated in the short term treatment of congestive heart failure. Ensifentrine A phosphodiesterase inhibitor used for the maintenance treatment of chronic obstructive pulmonary disease (COPD) in adults. Etazolate Investigated for use/treatment in alzheimer's disease and neurologic disorders. GSK-256066 Gsk256066 has been used in trials studying the treatment and diagnostic of SAR, Asthma, Mild Asthma, Allergic Rhinitis, and Seasonal Allergic Rhinitis, among others. Ibudilast For the treatment of multiple sclerosis, asthma, and cerebrovascular disease. Imazodan Imazodan is a small molecule drug. The usage of the INN stem '-dan' in the name indicates that Imazodan is a cardiac stimulant, pimobendan derivative. Imazodan has a monoisotopic molecular... Levosimendan A calcium sensitizer indicated to treat acutely decompensated severe chronic heart failure. Lotamilast E6005 has been used in trials studying the treatment of Atopic Dermatitis. Milrinone A PDE-III inhibitor with inotropic, lusitropic, and vasodilatory properties used for the short-term treatment of acute decompensated heart failure. Mirodenafil Mirodenafil has been used in trials studying the treatment and supportive care of Kidney Diseases, Urologic Diseases, Renal Insufficiency, Erectile Dysfunction, and Male Erectile Dysfunction. MK-0873 MK-0873 has been used in trials studying the treatment of Rheumatoid Arthritis. Nerandomilast A phosphodiesterase 4 inhibitor used to treat idiopathic pulmonary fibrosis in adults. Olprinone Not Annotated OSI-461 Investigated for use/treatment in crohn's disease, inflammatory bowel disease, kidney cancer, leukemia (lymphoid), and prostate cancer. Osoresnontrine Osoresnontrine is under investigation in clinical trial NCT02281773 (A Study to Investigate the Efficacy, Safety and Tolerability of Four Different Doses of BI 409306 Compared to Placebo Given for 12... Papaverine An alkaloid used to treat many types of smooth muscle spasms such as "vascular spasms" associated with acute myocardial infarction and angina pectoris, as well as "visceral spasms". Pentoxifylline A methylxanthine derivative used to treat intermittent claudication caused by chronic occlusive arterial disease of the limbs. PF-03049423 FREE BASE Not Annotated PF-04447943 PF-04447943 has been investigated for the treatment of Alzheimer's Disease. Piclamilast Piclamilast (RP-73,401), is a selective PDE4 inhibitor comparable to other PDE4 inhibitors for its anti-inflammatory effects. It has been investigated for its applications to the treatment of conditions such as... Pimobendan Not Annotated Piroximone Piroximone is a small molecule drug. Piroximone has a monoisotopic molecular weight of 217.09 Da. Roflumilast A selective phosphodiesterase-4 inhibitor indicated to decrease the risk of exacerbations in patients with severe chronic obstructive pulmonary disease (COPD) and to treat skin conditions such as plaque psoriasis and atopic dermatitis. Rolipram A phosphodiesterase inhibitor with antidepressant properties. Sildenafil A phosphodiesterase inhibitor used for the treatment of erectile dysfunction. Simendan Not Annotated Tadalafil A phosphodiesterase 5 inhibitor used to treat erectile dysfunction, benign prostatic hyperplasia, and pulmonary arterial hypertension. Theophylline A xanthine used to manage the symptoms of asthma, COPD, and other lung conditions caused by reversible airflow obstruction. Trapidil Used in the treatment of chronic stable angina . Udenafil A PDE5 inhibitor used to treat erectile dysfunction. Vardenafil A phosphodiesterase 5 inhibitor used to treat erectile dysfunction. Vesnarinone Vesnarinone has been used in trials studying the treatment of HIV Infections and Sarcoma, Kaposi. Vinpocetine A synthetic derivative of a vinca alkaloid used to treat neurological symptoms of cerebrovascular disease. Zaprinast Zaprinast is a small molecule drug. Zaprinast has a monoisotopic molecular weight of 271.11 Da. Zardaverine Not Available Zatolmilast BPN-14770 is under investigation in clinical trial NCT02840279 (A Multiple Ascending Dose Study of BPN14770 in Healthy Young and Elderly Male or Female Subjects).