Isobutyrates

Name
Isobutyrates
Accession Number
DBCAT001019
Description

Aliphatic acids that contain four carbons in a branched-chain configuration. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain the 2-carboxypropane structure.

Drugs
DrugDrug Description
ClofibrateA fibric acid derivative used to treat hypertriglyceridemia and high cholesterol.
FenofibrateA peroxisome proliferator receptor alpha activator used to lower LDL-C, total-C, triglycerides, and Apo B, while increasing HDL-C in hypercholesterolemia, dyslipidemia, and hypertriglyceridemia.
GemfibrozilA lipid regulator that is used in the reduction of serum triglyceride levels in high-risk patients with hyperlipidemia.
BezafibrateA lipid-lowering fibrate used in the management of primary and secondary hyperlipidaemia, when there is a lack of clinical improvement following lifestyle modifications or correction of the underlying disorder.
2-aminoisobutyric acidNot Available
EtofibrateEtofibrate is a fibrate produced by the combination of clofibrate ester linked to niacin. These components separate in the body slowly allowing for pharmacokinetics similar to controlled-release formulations.
CiprofibrateNot Annotated
SimfibrateNot Annotated
ClofibrideNot Annotated
Fenofibric acidA fibrate used to treat severe hypertriglyceridemia, primary hypercholesterolemia, or mixed dyslipidemia.
Drugs & Drug Targets
DrugTargetType
ClofibratePeroxisome proliferator-activated receptor alphatarget
ClofibrateCytochrome P450 3A4enzyme
ClofibrateGlutathione S-transferase A2enzyme
ClofibrateCytochrome P450 2E1enzyme
ClofibrateCytochrome P450 1A1enzyme
ClofibrateCytochrome P450 4A11enzyme
ClofibrateThyroxine-binding globulincarrier
FenofibratePeroxisome proliferator-activated receptor alphatarget
FenofibrateMatrix metalloproteinase-25target
FenofibrateCytochrome P450 2C8enzyme
FenofibrateCytochrome P450 2C9enzyme
FenofibrateNuclear receptor subfamily 1 group I member 2target
FenofibrateUDP-glucuronosyltransferase 1-9enzyme
FenofibrateBile salt export pumptransporter
FenofibrateSerum albumincarrier
FenofibrateCytochrome P450 2C19enzyme
FenofibrateCytochrome P450 2A6enzyme
FenofibrateLiver carboxylesterase 1enzyme
FenofibrateCarbonyl reductase [NADPH] 1enzyme
FenofibrateAldo-keto reductase family 1 member C1enzyme
FenofibrateAldo-keto reductase family 1 member C2enzyme
FenofibrateAldo-keto reductase family 1 member C3enzyme
FenofibrateAldose reductaseenzyme
GemfibrozilPeroxisome proliferator-activated receptor alphatarget
GemfibrozilCytochrome P450 2C9enzyme
GemfibrozilCytochrome P450 2C8enzyme
GemfibrozilCytochrome P450 1A2enzyme
GemfibrozilCytochrome P450 2C19enzyme
GemfibrozilUDP-glucuronosyltransferase 1-1enzyme
GemfibrozilCytochrome P450 3A4enzyme
GemfibrozilUDP-glucuronosyltransferase 1-3enzyme
GemfibrozilSolute carrier organic anion transporter family member 1B1target
GemfibrozilUDP-glucuronosyltransferase 2B7enzyme
GemfibrozilUDP-glucuronosyltransferase 1-9enzyme
GemfibrozilUDP-glucuronosyltransferase 2B4enzyme
GemfibrozilUDP-glucuronosyltransferase 2B17enzyme
GemfibrozilSerum albumincarrier
GemfibrozilSolute carrier family 22 member 8target
GemfibrozilSolute carrier organic anion transporter family member 2B1target
GemfibrozilSolute carrier organic anion transporter family member 1B3target
BezafibratePeroxisome proliferator-activated receptor alphatarget
BezafibrateSolute carrier organic anion transporter family member 1B1transporter
BezafibratePeroxisome proliferator-activated receptor deltatarget
BezafibratePeroxisome proliferator-activated receptor gammatarget
BezafibrateCytochrome P450 1A1enzyme
BezafibrateCytochrome P450 2C8enzyme
BezafibrateCytochrome P450 3A4enzyme
BezafibrateNuclear receptor subfamily 1 group I member 2target
BezafibrateRetinoic acid receptor RXR-alphatarget
BezafibrateRetinoic acid receptor RXR-betatarget
BezafibrateRetinoic acid receptor RXR-gammatarget
2-aminoisobutyric acidCorticoliberintarget
2-aminoisobutyric acidPro-neuropeptide Ytarget
2-aminoisobutyric acidMonocarboxylate transporter 10transporter
CiprofibratePeroxisome proliferator-activated receptor alphatarget
Fenofibric acidPeroxisome proliferator-activated receptor alphatarget
Fenofibric acidMatrix metalloproteinase-25target
Fenofibric acidPeroxisome proliferator-activated receptor gammatarget
Fenofibric acidPeroxisome proliferator-activated receptor deltatarget
Fenofibric acidNuclear receptor subfamily 1 group I member 2target