Neurokinin-1 Receptor Antagonists

Neurokinin-1 Receptor Antagonists
Accession Number

Compounds that inhibit or block the activity of NEUROKININ-1 RECEPTORS.

DrugDrug Description
AprepitantA substance P/neurokinin 1 receptor antagonist used to treat nausea and vomiting caused by chemotherapy and surgery.
FosaprepitantAn antiemetic drug used in combination with other antiemetic agents for the prevention of acute and delayed nausea and vomiting caused by chemotherapy.
CasopitantInvestigated for use/treatment in urinary incontinence and adverse effects (chemotherapy).
RolapitantA neurokinin-1 (NK-1) receptor antagonist used in combination with other antiemetics for the prevention of delayed nausea and vomiting associated with emetogenic chemotherapy.
VestipitantVestipitant has been investigated for the treatment of Tinnitus.
VofopitantVofopitant has been used in trials studying the treatment of PTSD, Primary Insomnia, and Sleep Initiation and Maintenance Disorders.
SerlopitantSerlopitant has been investigated for the treatment of Prurigo Nodularis.
RP-67580Not Annotated
Drugs & Drug Targets
AprepitantNeurokinin 1 receptortarget
AprepitantCytochrome P450 3A4enzyme
AprepitantCytochrome P450 2C9enzyme
AprepitantCytochrome P450 2C19enzyme
FosaprepitantCytochrome P450 3A4enzyme
FosaprepitantCytochrome P450 2C9enzyme
CasopitantCytochrome P450 3A4target
CasopitantNeurokinin 1 receptortarget
RolapitantNeurokinin 1 receptortarget
RolapitantCytochrome P450 2D6enzyme
RolapitantCytochrome P450 3A4enzyme
RolapitantATP-binding cassette sub-family G member 2transporter
RolapitantP-glycoprotein 1transporter
VestipitantNeurokinin 1 receptortarget
VofopitantNeurokinin 1 receptortarget