Pentacyclic Triterpenes

Name
Pentacyclic Triterpenes
Accession Number
DBCAT001473
Description

Five-ring derivatives of dammarane having a chair-chair-chair-boat configuration. They include the lupanes, oleananes, amyrins, GLYCYRRHIZIC ACID, and soyasaponins.

Drugs
DrugDrug Description
EnoxoloneEnoxolone (glycyrrhetic acid) has been investigated for the basic science of Apparent Mineralocorticoid Excess (AME).
Glycyrrhizic acidGlycyrrhizic acid is widely applied in foods as a natural sweetener. As a therapeutic agent, is has been used in a vast variety of formulations as it is reported to...
EscinAn anti-inflammatory and vasoconstrictive agent indicated to treat minor muscle and joint trauma.
beta-EscinAn anti-inflammatory and vasoconstrictive agent indicated to treat minor muscle and joint trauma.
CarbenoxoloneA drug used to symptomatically treat lip sores and mouth ulcers.
Bardoxolone methylInvestigated for use/treatment in lymphoma (unspecified), multiple myeloma, and solid tumors.
BardoxoloneBardoxolone has been used in trials studying the treatment of LYMPHOMA and Solid Tumors. It is a synthetic triterpenoid and a highly potent activator of redox-sensitive signaling pathways that induce...
AcetoxoloneNot Annotated
Betulinic AcidBetulinic Acid has been used in trials studying the treatment of Dysplastic Nevus Syndrome.
LupeolLupeol has been investigated for the treatment of Acne.
Ursolic acidNot Annotated
BetulinNot Annotated
Drugs & Drug Targets
DrugTargetType
Glycyrrhizic acidCorticosteroid 11-beta-dehydrogenase isozyme 1target
Glycyrrhizic acidAldo-keto reductase family 1 member C4carrier
Glycyrrhizic acidAldo-keto reductase family 1 member C3carrier
Glycyrrhizic acidAldo-keto reductase family 1 member C2carrier
Glycyrrhizic acidTumor necrosis factortarget
Glycyrrhizic acidCaspase-3target
Glycyrrhizic acidNuclear factor NF-kappa-Btarget
Glycyrrhizic acidLipoprotein lipasetarget
Glycyrrhizic acidSerum albumincarrier
Glycyrrhizic acidBile salt export pumptransporter
Carbenoxolone3-alpha-(or 20-beta)-hydroxysteroid dehydrogenasetarget
CarbenoxoloneCorticosteroid 11-beta-dehydrogenase isozyme 1target
Bardoxolone methylNF-kappa-B inhibitor alphatarget
BardoxoloneCaspase-8target
LupeolNeutrophil elastasetarget
Ursolic acidGTPase HRastarget
Ursolic acidNeutrophil elastasetarget