Endothelin A Receptor Antagonists
- Name
- Endothelin A Receptor Antagonists
- Accession Number
- DBCAT001698
- Description
Compounds and drugs that bind to and inhibit or block the activation of ENDOTHELIN A RECECPTORS.
- Drugs
Drug Drug Description Actelion-1 Investigated for use/treatment in cardiovascular disorders, hypertension, and pulmonary hypertension. TBC-3711 Investigated for use/treatment in congestive heart failure, hypertension, and pulmonary hypertension. Macitentan An endothelin receptor antagonist used to manage pulmonary arterial hypertension to delay disease progression. Atrasentan Investigated for use/treatment in prostate cancer and cancer/tumors (unspecified). - Drugs & Drug Targets
Drug Target Type Actelion-1 Endothelin-1 receptor target TBC-3711 Endothelin-1 target Macitentan Cytochrome P450 3A4 enzyme Macitentan Cytochrome P450 2C19 enzyme Macitentan Endothelin-1 receptor target Macitentan Endothelin B receptor target Macitentan Serum albumin carrier Macitentan Cytochrome P450 2C9 enzyme Macitentan Cytochrome P450 2C8 enzyme Macitentan alpha1-acid glycoprotein carrier Atrasentan Endothelin-1 receptor target