Endothelin A Receptor Antagonists

Name
Endothelin A Receptor Antagonists
Accession Number
DBCAT001698
Description

Compounds and drugs that bind to and inhibit or block the activation of ENDOTHELIN A RECECPTORS.

Drugs
DrugDrug Description
Actelion-1Investigated for use/treatment in cardiovascular disorders, hypertension, and pulmonary hypertension.
TBC-3711Investigated for use/treatment in congestive heart failure, hypertension, and pulmonary hypertension.
MacitentanAn endothelin receptor antagonist used to manage pulmonary arterial hypertension to delay disease progression.
AtrasentanInvestigated for use/treatment in prostate cancer and cancer/tumors (unspecified).
Drugs & Drug Targets
DrugTargetType
Actelion-1Endothelin-1 receptortarget
TBC-3711Endothelin-1target
MacitentanCytochrome P450 3A4enzyme
MacitentanCytochrome P450 2C19enzyme
MacitentanEndothelin-1 receptortarget
MacitentanEndothelin B receptortarget
MacitentanSerum albumincarrier
MacitentanCytochrome P450 2C9enzyme
MacitentanCytochrome P450 2C8enzyme
Macitentanalpha1-acid glycoproteincarrier
AtrasentanEndothelin-1 receptortarget