Serotonin 5-HT4 Receptor Agonists

Name
Serotonin 5-HT4 Receptor Agonists
Accession Number
DBCAT001723
Description

Endogenous compounds and drugs that specifically stimulate SEROTONIN 5-HT4 RECEPTORS.

Drugs
DrugDrug Description
NaronaprideInvestigated for use/treatment in gastroesophageal reflux disease (GERD) and gastroparesis.
FelcisetragFelcisetrag (TD-8954) has been used in trials studying the treatment of Enteral Feeding Intolerance and Gastrointestinal Motility Disorder.
RenzaprideFor the treatment of constipation-predominant irritable bowel syndrome (IBS-C).
PrucaloprideA 5-HT4 receptor agonist indicated to treat adults with chronic idiopathic constipation.
Drugs & Drug Targets
DrugTargetType
Naronapride5-hydroxytryptamine receptor 4target
Renzapride5-hydroxytryptamine receptor 3Atarget
Renzapride5-hydroxytryptamine receptor 4target
Prucalopride5-hydroxytryptamine receptor 4target
PrucaloprideCytochrome P450 3A4enzyme
PrucaloprideSerum albumincarrier
PrucaloprideP-glycoprotein 1transporter