Serotonin Receptor Agonists
- Serotonin Receptor Agonists
- Accession Number
Endogenous compounds and drugs that bind to and activate SEROTONIN RECEPTORS. Many serotonin receptor agonists are used as ANTIDEPRESSANTS; ANXIOLYTICS; and in the treatment of MIGRAINE DISORDERS.
Drug Drug Description Eletriptan A triptan used for the treatment of migraines. Zolmitriptan A member of the triptan class of 5-HT(1B/1D/1F) receptor agonist drugs used for the acute treatment of migraine with or without aura in adults. Lisuride For the management of Parkinson's Disease Sumatriptan A serotonin receptor agonist used to treat migraines and cluster headaches. Ergotamine A alpha-1 selective adrenergic agonist vasoconstrictor used to treat migraines with or without aura and cluster headaches. Almotriptan A 5-HT1B/1D receptor agonist used to treat migraines. Naratriptan A 5-HT1B/1D receptor agonist used to treat migraines. Rizatriptan A 5-HT1B/1D receptor agonist used to treat migraines. Frovatriptan A 5-HT1B/1D receptor agonist used to treat migraines. 4-Bromo-2,5-dimethoxyamphetamine Not Available Dimethyltryptamine Some people use this compound as a psychedelic inducing agent. Lysergic acid diethylamide Debate continues over the nature and causes of chronic flashbacks. Explanations in terms of LSD physically remaining in the body for months or years after consumption have been discounted by... Naronapride Investigated for use/treatment in gastroesophageal reflux disease (GERD) and gastroparesis. Naluzotan Investigated for use/treatment in anxiety disorders and depression. Vilazodone An antidepressant agent used for the treatment of major depressive disorder that targets the 5-HT transporter and 5-HT1A receptors. Serotonin For temporary relief of nervousness, anxiety, mood swings, joint pains, weakness, drowsiness, itching and lethargy. Not evaluated by the FDA, homeopathic product. Vortioxetine An atypical antipsychotic and antidepressant indicated for the treatment of major depressive disorder (MDD). Mosapride A prokinetic 5-HT4 receptor agonist used to stimulate gastric motility. m-Chlorophenylpiperazine m-Chlorophenylpiperazine has been used in trials studying the treatment of Alcoholism. MK-212 MK-212 has been used in trials studying the treatment of Alcoholism. Gepirone Gepirone has been used in trials studying the treatment of Cocaine-Related Disorders. Piclozotan Piclozotan has been investigated for the treatment of Parkinson's Disease. Urapidil A combination adrenergic antagonist and serotonin agonist given orally for the treatment of essential hypertension and intravenously in hypertensive emergencies. Tandospirone Tandospirone has been used in trials studying the treatment of Schizophrenia. Eltoprazine Eltoprazine has been used in trials studying the treatment of Schizophrenia and Cognitive Impairment. Dihydroergotamine An ergot alkaloid used in the acute treatment of migraine headache and cluster headache. Cabergoline A dopamine receptor agonist used for the treatment of hyperprolactinemic conditions due to various causes. Ziprasidone An atypical antipsychotic used to manage schizophrenia, bipolar mania, and agitation in patients with schizophrenia. Flibanserin A 5-HT receptor modulator used for the treatment of selected premenopausal women with acquired, generalized hypoactive sexual desire disorder (HSDD). Rotigotine A non-selective dopamine agonist used for the treatment of Parkinson's Disease and Restless Leg Syndrome. Cinitapride A benzamide with gastroprokinetic and antiemetic properties typically used for the treatment of gastrointestinal motility disorders such as gastroesophageal reflux disease (GERD), non-ulcer dyspepsia, and delayed gastric emptying. Brexpiprazole A serotonin–dopamine activity modulator used in the treatment of major depressive disorder as an adjunct and schizophrenia. Cariprazine An atypical antipsychotic used to treat schizophrenia and acute manic or mixed episodes due to bipolar I disorder. 5-methoxy-N,N-dimethyltryptamine 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is a tryptamine with psychedelic properties. It is found in a wide variety of plant species, and a single psychoactive toad species, the Colorado River toad. This drug,... Tetrahydrocannabivarin THCV does not currently have any FDA, Health Canada, or EMA approved indications. Fenfluramine Fenfluramine is a phenethylamine that is structurally similar to serotonin. Due to its ability to increase extracellular serotonin levels, modulate serotonergic and other neurologic receptors, and control neurotransmission, it is effective in treating pharmacoresistant seizures. Pergolide A long-acting dopamine agonist that is uncommonly used for the management of Parkinson's disease, due to the risk for cardiac valvulopathy. Bromocriptine A dopamine D2 receptor agonist used for the treatment of galactorrhea due to hyperprolactinemia and other prolactin-related conditions, as well as in early Parkinsonian Syndrome. Midomafetamine Clinical trials are now testing the therapeutic potential of MDMA for post-traumatic stress disorder (PTSD) and anxiety associated with terminal cancer. MDMA is one of the four most widely used... MMDA MMDA is a recreational drug. It has no current medical uses and is a Schedule I controlled substance in the USA at present. 2,5-Dimethoxy-4-ethylthioamphetamine 2,5-Dimethoxy-4-ethylthioamphetamine (ALEPH-2) is a phenylisopropylamine derivative with alleged anxiolytic and hallucinogenic properties. N-(2-hydroxybenzyl)-2,5-dimethoxy-4-cyanophenylethylamine 25CN-NBOH (N-(2-hydroxybenzyl)-2,5-dimethoxy-4-cyanophenylethylamine) is a newly developed selective 5-HT2A agonist. It has been tested with regard to the head-twitch-response (HTR) model of 5-HT2A activity and effects on locomotion . It was... Lofexidine A centrally acting alpha2-adrenergic agonist used for the symptomatic treatment of acute opioid withdrawal syndrome to facilitate abrupt opioid discontinuation in adults. TD-8954 TD-8954 has been used in trials studying the treatment of Enteral Feeding Intolerance and Gastrointestinal Motility Disorder. Lorcaserin A serotonin 2C receptor agonist used in conjunction with physical activity and calorie restriction for weight loss in obese patients with a body mass index (BMI) of 30 and above, and in overweight patients with weight-related comorbidities. Vabicaserin Vabicaserin has been used in trials studying the health services research and treatment of Schizophrenia. Cannabidiol An active cannabinoid used as an adjunctive treatment for the management of seizures associated with Lennox-Gastaut syndrome or Dravet syndrome and symptomatic relief of moderate to severe neuropathic pain or other painful conditions, like cancer. Cisapride A medication used to treat heartburn associated with GERD. Metergoline An ergot-derivative that acts as an antagonist at certain 5-HT receptor subtypes and as an agonist at dopamine receptors. It is often used in situations where inhibition of prolactin is desirable. Asenapine An atypical antipsychotic used to treat patients with bipolar I disorder and patients with schizophrenia. Renzapride For the treatment of constipation-predominant irritable bowel syndrome (IBS-C). Aripiprazole An atypical antipsychotic used in the treatment of a wide variety of mood and psychotic disorders, such as schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's syndrome. Prucalopride A P2Y12 platelet receptor antagonist used during percutaneous coronary intervention to reduce the risk for periprocedural myocardial infarction (MI), repeat coronary revascularization, and stent thrombosis (ST).
- Drugs & Drug Targets