Kinins
- Name
- Kinins
- Accession Number
- DBCAT001752
- Description
A generic term used to describe a group of polypeptides with related chemical structures and pharmacological properties that are widely distributed in nature. These peptides are AUTACOIDS that act locally to produce pain, vasodilatation, increased vascular permeability, and the synthesis of prostaglandins. Thus, they comprise a subset of the large number of mediators that contribute to the inflammatory response. (From Goodman and Gilman's The Pharmacologic Basis of Therapeutics, 8th ed, p588)
- Drugs
Drug Drug Description Icatibant A bradykinin B2 receptor antagonist used to treat acute episodes of swelling and inflammation associated with hereditary angioedema (HAE). Labradimil Investigated for use/treatment in brain cancer and pediatric indications. Bradykinin Bradykinin has been investigated for the basic science and treatment of Hypertension and Diabetes Type 2. Sar9, Met (O2)11-Substance P Investigated for use/treatment in acute respiratory distress syndrome (ARDS) and viral infection. - Drugs & Drug Targets