Sar9, Met (O2)11-Substance P

DB05875InvestigationalSmall molecule

Sar9, Met (O2)11-Substance P is a neurokinin-1 receptor agonist. It is an analog of the naturally occurring human neuropeptide Substance P, which can be found throughout the body, including in...

Mechanism: The endogenous receptor for Substance P is neurokinin 1 receptor (NK1-receptor, NK1R). Substance P has been shown to stimulate cellular growth in cell culture, and it was shown that Substance P could promote wound healing of non-healing ulcers in humans. It has also been shown to reverse diabetes in mice.
Curator reviewed
Primary indication: Investigated for use/treatment in acute respiratory distress syndrome (ARDS) and viral infection.Curator reviewed
Formula / weight: C₆₄H₁₀₀N₁₈O₁₅S · 1393.68 g/mol (avg)
Also known as: 9-Sar-substance P sulfone · 9-Sarcosyl-11-methionine(O2)-substance P · Bolton hunter-9-sar-11-met(02)-substance P · Sarcosyl(9)-substance P sulfone

Resolves to

Compound

UNII8V0QAFPRXVCAS110880-55-2ChEMBLCHEMBL1651026

Structure

InChIKeyOUPXSLGGCPUZJJ-SARDKLJWSA-NSMILES

CC(C)C[C@H](NC(=O)CN(C)C(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CCS(C)(=O)=O)C(N)=O

Targets

P25103TACR1

What you can answer from here — as of July 09, 2025

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

76Drug interactionsStructured to mechanism, not free text

9+ReferencesStructured and connected to the statements they support

Which drugs share a target with Sar9, Met (O2)11-Substance P, and which of those have an active Phase 3 trial?

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