Janus Kinase 1, antagonists & inhibitors

Name
Janus Kinase 1, antagonists & inhibitors
Accession Number
DBCAT002066
Description

Not Available

Drugs
DrugDrug Description
OclacitinibNot Annotated
FilgotinibA Janus kinase (JAK) 1 selective inhibitor used to treat cases of rheumatoid arthritis that are unresponsive to conventional treatments.
AbrocitinibA kinase inhibitor used to treat moderate-to-severe atopic dermatitis in adults.
IvarmacitinibA selective JAK1 inhibitor under investigation for the treatment of immuno-inflammatory diseases.
Drugs & Drug Targets
DrugTargetType
FilgotinibTyrosine-protein kinase JAK1target
FilgotinibCocaine esteraseenzyme
FilgotinibLiver carboxylesterase 1enzyme
FilgotinibP-glycoprotein 1transporter
AbrocitinibCytochrome P450 2C19enzyme
AbrocitinibCytochrome P450 2C9enzyme
AbrocitinibCytochrome P450 3A4enzyme
AbrocitinibCytochrome P450 2B6enzyme
AbrocitinibTyrosine-protein kinase JAK1target
AbrocitinibP-glycoprotein 1transporter
AbrocitinibSolute carrier family 22 member 1transporter
AbrocitinibTyrosine-protein kinase JAK2target
AbrocitinibTyrosine-protein kinase JAK3target
AbrocitinibNon-receptor tyrosine-protein kinase TYK2target
AbrocitinibSerum albumincarrier
AbrocitinibSolute carrier family 22 member 8transporter
IvarmacitinibTyrosine-protein kinase JAK1target