Janus Kinases, antagonists & inhibitors

Name
Janus Kinases, antagonists & inhibitors
Accession Number
DBCAT001908
Description

Not Available

Drugs
DrugDrug Description
RuxolitinibA kinase inhibitor used to treat various types of myelofibrosis, polycythemia vera in patients who have not responded to or cannot tolerate hydroxyurea, and to treat graft-versus-host disease in cases that are refractory to steroid treatment.
TofacitinibA Janus kinase (JAK) inhibitor used to treat rheumatic conditions, such as rheumatoid arthritis and ankylosing spondylitis, and ulcerative colitis.
OclacitinibNot Annotated
PacritinibA kinase inhibitor used for the treatment of primary and secondary myelofibrosis in adult patients with significantly reduced platelet counts.
AZD-1480AZD1480 has been used in trials studying the treatment of Solid Malignancies, Post-Polycythaemia Vera, Primary Myelofibrosis (PMF), and Essential Thrombocythaemia Myelofibrosis.
BMS-911543BMS-911543 has been used in trials studying the treatment of Cancer.
GandotinibGandotinib has been used in trials studying the treatment of Myelofibrosis, Polycythemia Vera, Primary Myelofibrosis, Thrombocythemia, Essential, and Myeloproliferative Disorders, among others.
FilgotinibA Janus kinase (JAK) 1 selective inhibitor used to treat cases of rheumatoid arthritis that are unresponsive to conventional treatments.
RitlecitinibA kinase inhibitor used to treat severe alopecia areata in adults and adolescents 12 years and older.
AbrocitinibA kinase inhibitor used to treat moderate-to-severe atopic dermatitis in adults.
IvarmacitinibA selective JAK1 inhibitor under investigation for the treatment of immuno-inflammatory diseases.
Drugs & Drug Targets
DrugTargetType
RuxolitinibTyrosine-protein kinase JAK1target
RuxolitinibTyrosine-protein kinase JAK2target
RuxolitinibCytochrome P450 3A4enzyme
RuxolitinibCytochrome P450 2C9enzyme
RuxolitinibSerum albumincarrier
RuxolitinibTyrosine-protein kinase JAK3target
RuxolitinibNon-receptor tyrosine-protein kinase TYK2target
TofacitinibNon-receptor tyrosine-protein kinase TYK2target
TofacitinibCytochrome P450 3A4enzyme
TofacitinibCytochrome P450 2C19enzyme
TofacitinibTyrosine-protein kinase JAK2target
TofacitinibTyrosine-protein kinase JAK1target
TofacitinibTyrosine-protein kinase JAK3target
TofacitinibSerum albumincarrier
PacritinibCytochrome P450 3A4enzyme
PacritinibCytochrome P450 1A2enzyme
PacritinibTyrosine-protein kinase JAK2target
PacritinibReceptor-type tyrosine-protein kinase FLT3target
PacritinibP-glycoprotein 1transporter
PacritinibATP-binding cassette sub-family G member 2transporter
PacritinibSolute carrier family 22 member 1transporter
PacritinibCytochrome P450 2C19enzyme
PacritinibSolute carrier family 22 member 2transporter
FilgotinibTyrosine-protein kinase JAK1target
FilgotinibCocaine esteraseenzyme
FilgotinibLiver carboxylesterase 1enzyme
FilgotinibP-glycoprotein 1transporter
RitlecitinibTyrosine-protein kinase JAK3target
RitlecitinibTyrosine-protein kinase Tectarget
RitlecitinibTyrosine-protein kinase ITK/TSKtarget
RitlecitinibTyrosine-protein kinase TXKtarget
RitlecitinibTyrosine-protein kinase BTKtarget
RitlecitinibCytoplasmic tyrosine-protein kinase BMXtarget
RitlecitinibCytochrome P450 3A4enzyme
RitlecitinibCytochrome P450 2C8enzyme
RitlecitinibCytochrome P450 1A2enzyme
RitlecitinibCytochrome P450 2C9enzyme
RitlecitinibGlutathione S-transferase A1enzyme
RitlecitinibGlutathione S-transferase A3enzyme
RitlecitinibGlutathione S-transferase Mu 1enzyme
RitlecitinibGlutathione S-transferase Mu 3enzyme
RitlecitinibGlutathione S-transferase Mu 5enzyme
RitlecitinibGlutathione S-transferase Penzyme
RitlecitinibGlutathione S-transferase theta-2enzyme
RitlecitinibMaleylacetoacetate isomeraseenzyme
RitlecitinibMicrosomal glutathione S-transferase 1enzyme
RitlecitinibMicrosomal glutathione S-transferase 2enzyme
RitlecitinibMicrosomal glutathione S-transferase 3enzyme
AbrocitinibCytochrome P450 2C19enzyme
AbrocitinibCytochrome P450 2C9enzyme
AbrocitinibCytochrome P450 3A4enzyme
AbrocitinibCytochrome P450 2B6enzyme
AbrocitinibTyrosine-protein kinase JAK1target
AbrocitinibP-glycoprotein 1transporter
AbrocitinibSolute carrier family 22 member 1transporter
AbrocitinibTyrosine-protein kinase JAK2target
AbrocitinibTyrosine-protein kinase JAK3target
AbrocitinibNon-receptor tyrosine-protein kinase TYK2target
AbrocitinibSerum albumincarrier
AbrocitinibSolute carrier family 22 member 8transporter
IvarmacitinibTyrosine-protein kinase JAK1target