Microtubule Inhibitors

Name
Microtubule Inhibitors
Accession Number
DBCAT002734
Description

Not Available

Drugs
DrugDrug Description
CabazitaxelAn antineoplastic agent used in combination with corticosteroids to treat metastatic castration-resistant prostate cancer in patients previously treated with a docetaxel-containing treatment regimen.
DocetaxelA taxoid antineoplastic agent used in the treatment of various cancers, such as locally advanced or metastatic breast cancer, metastatic prostate cancer, gastric adenocarcinoma, and head and neck cancer.
Enfortumab vedotinAn antibody-drug conjugate comprised of a fully human monoclonal antibody and microtubule-disrupting chemotherapeutic agent used in the treatment of advanced or metastatic urothelial cancer.
EribulinA microtubule inhibitor used to treat metastatic breast cancer and metastatic or unresectable liposarcoma.
IxabepiloneA microtubule inhibitor administered in combination with capecitabine or alone in the treatment of metastatic or locally advanced breast cancer that has shown inadequate response to taxanes and anthracyclines.
PaclitaxelA taxoid chemotherapeutic agent used as first-line and subsequent therapy for the treatment of advanced carcinoma of the ovary, and other various cancers including breast and lung cancer.
Paclitaxel ceribateNot Available
Telisotuzumab vedotinAn chemotherapeutic antibody-drug conjugate comprising a c-Met-directed antibody with a microtubule-disrupting small molecule payload.
TirbanibulinA tyrosine kinase and tubulin inhibitor used to treat actinic keratosis on the face or scalp.
Trastuzumab emtansineAn antineoplastic agent and antibody-drug conjugate used to treat HER2-overexpressing breast cancer.
Drugs & Drug Targets
DrugTargetType
CabazitaxelCytochrome P450 2C8enzyme
CabazitaxelGlycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1carrier
CabazitaxelVery low-density lipoprotein receptorcarrier
CabazitaxelLow-density lipoprotein receptorcarrier
CabazitaxelAlbumincarrier
CabazitaxelSolute carrier organic anion transporter family member 1B3transporter
CabazitaxelSolute carrier organic anion transporter family member 1B1transporter
CabazitaxelTubulin beta-1 chaintarget
CabazitaxelBroad substrate specificity ATP-binding cassette transporter ABCG2transporter
CabazitaxelATP-dependent translocase ABCB1transporter
CabazitaxelCytochrome P450 3A5enzyme
CabazitaxelCytochrome P450 3A4enzyme
DocetaxelNuclear receptor subfamily 1 group I member 2target
DocetaxelApoptosis regulator Bcl-2target
DocetaxelTubulin beta-1 chaintarget
DocetaxelCytochrome P450 3A4enzyme
DocetaxelCytochrome P450 3A5enzyme
DocetaxelCytochrome P450 3A7enzyme
DocetaxelATP-dependent translocase ABCB1transporter
DocetaxelATP-binding cassette sub-family C member 10transporter
DocetaxelCytochrome P450 1B1enzyme
DocetaxelSolute carrier organic anion transporter family member 1B3transporter
DocetaxelSolute carrier family 22 member 7transporter
DocetaxelBroad substrate specificity ATP-binding cassette transporter ABCG2transporter
DocetaxelATP-binding cassette sub-family C member 2transporter
DocetaxelMultidrug resistance-associated protein 1transporter
Enfortumab vedotinATP-dependent translocase ABCB1transporter
Enfortumab vedotinNectin-4target
Enfortumab vedotinCytochrome P450 3A4enzyme
EribulinTubulin beta-1 chaintarget
IxabepiloneTubulin beta-3 chaintarget
IxabepiloneCytochrome P450 3A4enzyme
IxabepiloneATP-dependent translocase ABCB1transporter
PaclitaxelNuclear receptor subfamily 1 group I member 2target
PaclitaxelSolute carrier organic anion transporter family member 1B3transporter
PaclitaxelATP-binding cassette sub-family C member 2transporter
PaclitaxelCytochrome P450 1B1enzyme
PaclitaxelAromataseenzyme
PaclitaxelATP-binding cassette sub-family C member 10transporter
PaclitaxelMultidrug resistance-associated protein 1transporter
PaclitaxelATP-dependent translocase ABCB1transporter
PaclitaxelBile salt export pumptransporter
PaclitaxelCytochrome P450 3A7enzyme
PaclitaxelCytochrome P450 3A5enzyme
PaclitaxelCytochrome P450 3A4enzyme
PaclitaxelCytochrome P450 2C8enzyme
PaclitaxelTubulin beta-1 chaintarget
PaclitaxelApoptosis regulator Bcl-2target
Telisotuzumab vedotinATP-binding cassette sub-family B member 5transporter
Telisotuzumab vedotinHepatocyte growth factor receptortarget
Telisotuzumab vedotinCytochrome P450 3A4enzyme
Telisotuzumab vedotinCytochrome P450 3A5enzyme
TirbanibulinProto-oncogene tyrosine-protein kinase Srctarget
TirbanibulinTubulin beta chaintarget
TirbanibulinCytochrome P450 3A4enzyme
TirbanibulinCytochrome P450 2C8enzyme
TirbanibulinCytochrome P450 1A2enzyme
TirbanibulinCytochrome P450 2B6enzyme
TirbanibulinCytochrome P450 2C9enzyme
TirbanibulinCytochrome P450 2C19enzyme
TirbanibulinCytochrome P450 2D6enzyme
TirbanibulinMultidrug and toxin extrusion protein 1transporter
TirbanibulinMultidrug and toxin extrusion protein 2transporter
TirbanibulinSolute carrier organic anion transporter family member 1B1transporter
TirbanibulinSolute carrier organic anion transporter family member 1B3transporter
TirbanibulinSolute carrier family 22 member 1transporter
TirbanibulinSolute carrier family 22 member 2transporter
Trastuzumab emtansineATP-dependent translocase ABCB1transporter
Trastuzumab emtansineReceptor tyrosine-protein kinase erbB-2target
Trastuzumab emtansineCytochrome P450 3A5enzyme
Trastuzumab emtansineCytochrome P450 3A4enzyme