Eribulin

DB08871ApprovedInvestigationalSmall moleculeMicrotubule Inhibitors

Eribulin is a microtubule inhibitor used to treat metastatic breast cancer and metastatic or unresectable liposarcoma. Eribulin was isolated from the marine sponge Halichondria okadai.

Mechanism: Eribulin inhibits the growth phase of microtubules without affecting the shortening phase and sequesters tubulin into nonproductive aggregates. Eribulin exerts its effects via a tubulin-based antimitotic mechanism leading to G2/M cell-cycle block, disruption of mitotic spindles, and, ultimately, apoptotic cell death after prolonged mitotic blockage. [FDA]
Curator reviewed
Primary indication: For the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic cancer.Curator reviewed · 3 structured indications
Formula / weight: C₄₀H₅₉NO₁₁ · 729.908 g/mol (avg)
First approval: Canada, 2011 · United States, 2010 · European Union, 2016
Code names: B1939 · ER-086526
Brand names: Halaven
Mevlyq

Resolves to

Compound

UNIILR24G6354GCAS253128-41-5ChEMBLCHEMBL1683590ChEBI63587PubChem11354606KEGGD08914

Clinical / RWD

RxNorm1045453ATCL01XX41

Structure

InChIKeyUFNVPOGXISZXJD-JBQZKEIOSA-NSMILES

[H][C@@]12CC(=C)[C@]([H])(CC[C@@]3([H])C[C@@H](C)C(=C)[C@@]([H])(C[C@]4([H])O[C@H](C[C@H](O)CN)[C@H](OC)[C@@]4([H])CC(=O)C[C@@]4([H])CC[C@]5([H])O[C@@]6([H])[C@H]7O[C@@]8(C[C@]7([H])O[C@@]6([H])[C@@]([H])(O8)[C@@]5([H])O4)CC1)O3)O2

Targets

Q9H4B7TUBB1

What you can answer from here — as of September 23, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

900Drug interactionsStructured to mechanism, not free text

201Clinical trialsPhase, status and sponsor resolved per trial

3Structured indicationsCondition, population, route and combination as fields, not prose

1ContraindicationEach with its own population and attribute set

50Marketed productsAcross 9 countries and 27 labellers

1ATC codeIncluding every combination product, plus 14 drug categories

5+ReferencesStructured and connected to the statements they support

Which drugs share a target with Eribulin, and which of those have an active Phase 3 trial?

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