NS3/4A Protease Inhibitors

All categories

Name: NS3/4A Protease Inhibitors
Accession Number: DBCAT002768 (DBCAT003456)
Description: Inhibitors of the NS3/4A serine protease of Hepatitis C Virus (HCV).
Drugs: Drug Drug Description
Boceprevir A hepatitis C virus NS3/4A protease inhibitor used in combination with other medications to treat chronic hepatitis C genotype 1 infection. Boceprevir is not indicated as monotherapy.
Glecaprevir A Hepatitis C NS3/4A protease inhibitor used to treat Hepatitis C.
Grazoprevir An antiviral and NS3/4A protease inhibitor used to treat hepatitis C infections.
Paritaprevir A direct acting antiviral agent used in combination with other antiviral agents for the treatment of Hepatitis C Virus (HCV) infections.
Simeprevir A direct-acting antiviral agent that inhibits HCV NS3/4A protease to treat chronic hepatitis C virus (HCV) infection in adults with HCV genotype 1 or 4.
Telaprevir An NS3/4A viral protease inhibitor used in combination with other antivirals for the curative treatment of chronic Hepatitis C Virus infections.
Voxilaprevir A nonstructural protein 3 and 4a protease inhibitor used to treat Hepatitis C infections.
Drugs & Drug Targets: Drug Target Type
Boceprevir Cytochrome P450 3A4 enzyme
Boceprevir Cytochrome P450 3A5 enzyme
Boceprevir ATP-dependent translocase ABCB1 transporter
Boceprevir Genome polyprotein target
Boceprevir Genome polyprotein target
Glecaprevir Solute carrier organic anion transporter family member 1B3 transporter
Glecaprevir Solute carrier organic anion transporter family member 1B1 transporter
Glecaprevir Broad substrate specificity ATP-binding cassette transporter ABCG2 transporter
Glecaprevir ATP-dependent translocase ABCB1 transporter
Glecaprevir UDP-glucuronosyltransferase 1A1 enzyme
Glecaprevir Cytochrome P450 3A Subfamily enzyme
Glecaprevir NS3 protease target
Glecaprevir Cytochrome P450 3A4 enzyme
Glecaprevir Genome polyprotein target
Grazoprevir ATP-dependent translocase ABCB1 transporter
Grazoprevir Solute carrier organic anion transporter family member 1B1 transporter
Grazoprevir Solute carrier organic anion transporter family member 1B3 transporter
Grazoprevir Cytochrome P450 3A4 enzyme
Grazoprevir Genome polyprotein target
Grazoprevir Albumin carrier
Grazoprevir Alpha-1-acid glycoprotein 1 carrier
Grazoprevir Gag-Pol polyprotein target
Paritaprevir Gag-Pol polyprotein target
Paritaprevir UDP-glucuronosyltransferase 1A1 enzyme
Paritaprevir Solute carrier organic anion transporter family member 1B3 transporter
Paritaprevir Solute carrier organic anion transporter family member 1B1 transporter
Paritaprevir ATP-dependent translocase ABCB1 transporter
Paritaprevir Broad substrate specificity ATP-binding cassette transporter ABCG2 transporter
Paritaprevir Cytochrome P450 3A5 enzyme
Paritaprevir Cytochrome P450 3A4 enzyme
Paritaprevir Genome polyprotein target
Simeprevir ATP-binding cassette sub-family C member 2 transporter
Simeprevir Broad substrate specificity ATP-binding cassette transporter ABCG2 transporter
Simeprevir Solute carrier organic anion transporter family member 2B1 transporter
Simeprevir Hepatic sodium/bile acid cotransporter transporter
Simeprevir Bile salt export pump transporter
Simeprevir Genome polyprotein target
Simeprevir Genome polyprotein target
Simeprevir Cytochrome P450 3A4 enzyme
Simeprevir Solute carrier organic anion transporter family member 1B3 transporter
Simeprevir Solute carrier organic anion transporter family member 1B1 transporter
Simeprevir ATP-dependent translocase ABCB1 transporter
Simeprevir Cytochrome P450 1A2 enzyme
Simeprevir Albumin carrier
Simeprevir NS3 protease target
Telaprevir Genome polyprotein target
Telaprevir Solute carrier organic anion transporter family member 2B1 target
Telaprevir Solute carrier organic anion transporter family member 1B1 target
Telaprevir Alpha-1-acid glycoprotein 1 carrier
Telaprevir Albumin carrier
Telaprevir ATP-dependent translocase ABCB1 transporter
Telaprevir Genome polyprotein target
Telaprevir Cytochrome P450 3A4 enzyme
Voxilaprevir Cytochrome P450 3A4 enzyme
Voxilaprevir Cytochrome P450 1A2 enzyme
Voxilaprevir Cytochrome P450 2C8 enzyme
Voxilaprevir Genome polyprotein target
Voxilaprevir ATP-dependent translocase ABCB1 transporter
Voxilaprevir Broad substrate specificity ATP-binding cassette transporter ABCG2 transporter
Voxilaprevir Solute carrier organic anion transporter family member 1B1 transporter
Voxilaprevir Solute carrier organic anion transporter family member 1B3 transporter
Voxilaprevir Genome polyprotein target

Drug	Drug Description
Boceprevir	A hepatitis C virus NS3/4A protease inhibitor used in combination with other medications to treat chronic hepatitis C genotype 1 infection. Boceprevir is not indicated as monotherapy.
Glecaprevir	A Hepatitis C NS3/4A protease inhibitor used to treat Hepatitis C.
Grazoprevir	An antiviral and NS3/4A protease inhibitor used to treat hepatitis C infections.
Paritaprevir	A direct acting antiviral agent used in combination with other antiviral agents for the treatment of Hepatitis C Virus (HCV) infections.
Simeprevir	A direct-acting antiviral agent that inhibits HCV NS3/4A protease to treat chronic hepatitis C virus (HCV) infection in adults with HCV genotype 1 or 4.
Telaprevir	An NS3/4A viral protease inhibitor used in combination with other antivirals for the curative treatment of chronic Hepatitis C Virus infections.
Voxilaprevir	A nonstructural protein 3 and 4a protease inhibitor used to treat Hepatitis C infections.

NS3/4A Protease Inhibitors

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