Cyclodextrins

Name
Cyclodextrins
Accession Number
DBCAT002962
Description

A homologous group of cyclic GLUCANS consisting of alpha-1,4 bound glucose units obtained by the action of cyclodextrin glucanotransferase on starch or similar substrates. The enzyme is produced by certain species of Bacillus. Cyclodextrins form inclusion complexes with a wide variety of substances.

Drugs
DrugDrug Description
BetadexNot Available
SugammadexA modified gamma cyclodextrin used to reverse neuromuscular blockade induced by vecuronium bromide and rocuronium bromide which are agents used for anesthesia.
BrexanoloneBrexanolone is a synthetic neuroactive steroid gamma-aminobutyric acid A (GABA(a)) receptor positive modulator indicated for the treatment of postpartum depression (PPD) in adult women [FDA Label][A176080, A176083, F4063, F4066, F4072].
Hydroxypropyl betadexHydroxypropyl betadex is under investigation in clinical trial NCT03471143 (Study of IV VTS-270 for Infantile Liver Disease Associated With Niemann-Pick Disease, Type C).
Sulfobutylether-beta-cyclodextrinNot Annotated
Drugs & Drug Targets
DrugTargetType
BetadexNeopullulanase 2target
BetadexMaltose-binding periplasmic proteintarget
BetadexMaltogenic amylasetarget
BrexanoloneGABA(A) Receptortarget
BrexanoloneAldose reductaseenzyme