Cyclodextrins
- Name
- Cyclodextrins
- Accession Number
- DBCAT002962
- Description
A homologous group of cyclic GLUCANS consisting of alpha-1,4 bound glucose units obtained by the action of cyclodextrin glucanotransferase on starch or similar substrates. The enzyme is produced by certain species of Bacillus. Cyclodextrins form inclusion complexes with a wide variety of substances.
- Drugs
Drug Drug Description Betadex Not Available Sugammadex A modified gamma cyclodextrin used to reverse neuromuscular blockade induced by vecuronium bromide and rocuronium bromide which are agents used for anesthesia. Brexanolone Brexanolone is a synthetic neuroactive steroid gamma-aminobutyric acid A (GABA(a)) receptor positive modulator indicated for the treatment of postpartum depression (PPD) in adult women [FDA Label][A176080, A176083, F4063, F4066, F4072]. Hydroxypropyl betadex Hydroxypropyl betadex is under investigation in clinical trial NCT03471143 (Study of IV VTS-270 for Infantile Liver Disease Associated With Niemann-Pick Disease, Type C). Sulfobutylether-beta-cyclodextrin Not Annotated - Drugs & Drug Targets
Drug Target Type Betadex Neopullulanase 2 target Betadex Maltose-binding periplasmic protein target Betadex Maltogenic amylase target Brexanolone GABA(A) Receptor target Brexanolone Aldose reductase enzyme