Miscellaneous Anticonvulsants

Name
Miscellaneous Anticonvulsants
Accession Number
DBCAT003640
Description

Not Available

Drugs
DrugDrug Description
PregabalinAn anticonvulsant drug used to treat neuropathic pain conditions and fibromyalgia, and for the treatment of partial onset seizures in combination with other anticonvulsants.
TopiramateAn anticonvulsant drug used in the control of epilepsy and in the prophylaxis and treatment of migraines.
Valproic acidAn anticonvulsant used to control complex partial seizures and both simple and complex absence seizures.
LamotrigineA phenyltriazine antiepileptic used to treat some types of epilepsy and bipolar I disorder.
CarbamazepineAn anticonvulsant used to treat various types of seizures and pain resulting from trigeminal neuralgia.
Magnesium sulfateA drug used to treat convulsions during pregnancy, nephritis in children, magnesium deficiency, and tetany.
OxcarbazepineAn anti-epileptic used in the treatment of partial-onset seizures.
GabapentinAn anticonvulsant medication used in the management of peripheral neuropathic pains, postherpetic neuralgia, and partial-onset seizures.
VigabatrinAn irreversible GABA transaminase inhibitor used as an adjunct therapy to treat refractory complex partial seizures in patients ≥2 years unresponsive to alternatives. May also be used as monotherapy to treat infantile spasms in infants 1 month to 2 years.
LevetiracetamA novel anticonvulsant agent used as an adjunct medication to manage partial onset, myoclonic, and generalized tonic-clonic seizures in patients with epilepsy.
BrivaracetamAn anticonvulsant used for the treatment of partial-onset seizures that functions by binding to synaptic vesicle glycoprotein 2A (SV2A) in the brain.
RufinamideAn antiepileptic drug used as adjunctive therapy to treat seizures associated with Lennox-Gastaut Syndrome (LGS).
LacosamideAn antiepileptic drug used to treat partial-onset seizures and primary generalized tonic-clonic seizures.
PerampanelA non-competitive AMPA glutamate receptor antagonist used to treat partial-onset seizures with or without secondarily generalized seizures, and as adjunctive treatment of primary generalized tonic-clonic seizures in patients with epilepsy.
StiripentolAn antiepileptic agent used in combination with other anticonvulsants to treat seizures associated with Dravet syndrome.
Drugs & Drug Targets
DrugTargetType
PregabalinExcitatory amino acid transporter 3transporter
PregabalinVoltage-dependent calcium channel subunit alpha-2/delta-1target
PregabalinLarge neutral amino acids transporter small subunit 1transporter
TopiramateGamma-aminobutyric acid receptor subunit alpha-1target
TopiramateVoltage-gated sodium channel alpha subunittarget
TopiramateCarbonic anhydrase 2target
TopiramateCarbonic anhydrase 4target
TopiramateKainate receptorstarget
TopiramateCytochrome P450 2C19enzyme
TopiramateCytochrome P450 3A4enzyme
TopiramateCarbonic anhydrase 1target
TopiramateCarbonic anhydrase 3target
TopiramateVoltage gated L-type calcium channeltarget
TopiramateVoltage-dependent R-type calcium channeltarget
TopiramateAlbumincarrier
TopiramateATP-dependent translocase ABCB1transporter
Topiramate5'-AMP-activated protein kinasetransporter
TopiramateGlutamate receptor ionotropic, kainate 1target
Valproic acidHistone deacetylase 9target
Valproic acidShort/branched chain specific acyl-CoA dehydrogenase, mitochondrialtarget
Valproic acidCytochrome P450 2A6enzyme
Valproic acidCytochrome P450 2B6enzyme
Valproic acidCytochrome P450 2C9enzyme
Valproic acidOrganic cation/carnitine transporter 2transporter
Valproic acidSolute carrier family 22 member 6transporter
Valproic acidOrganic anion transporter 3transporter
Valproic acidMonocarboxylate transporter 1transporter
Valproic acidSolute carrier family 22 member 7transporter
Valproic acidCytochrome P450 3A5enzyme
Valproic acidUDP-glucuronosyltransferase 1A9enzyme
Valproic acidProstaglandin G/H synthase 1enzyme
Valproic acidCytochrome P450 1A2enzyme
Valproic acidCytochrome P450 2C19enzyme
Valproic acidCytochrome P450 3A4enzyme
Valproic acidUDP-glucuronosyltransferase 1A4enzyme
Valproic acidUDP-glucuronosyltransferase 1A8enzyme
Valproic acidUDP-glucuronosyltransferase 1A10enzyme
Valproic acidUDP-glucuronosyltransferase 1-6enzyme
Valproic acidUDP-glucuronosyltransferase 1A3enzyme
Valproic acidUDP-glucuronosyltransferase 2B7enzyme
Valproic acidUDP-glucuronosyltransferase 2B15enzyme
Valproic acid2-oxoglutarate dehydrogenase complex component E1target
Valproic acidSuccinate-semialdehyde dehydrogenase, mitochondrialtarget
Valproic acidSodium channel proteintarget
Valproic acidHistone deacetylase 2target
Valproic acidPeroxisome proliferator-activated receptor alphatarget
Valproic acidPeroxisome proliferator-activated receptor deltatarget
Valproic acidPeroxisome proliferator-activated receptor gammatarget
Valproic acidAlbumincarrier
Valproic acidUDP-glucuronosyltransferase 1A1enzyme
Valproic acidSolute carrier organic anion transporter family member 2B1transporter
Valproic acidHistone deacetylasetarget
Valproic acidCyclin-dependent kinase inhibitor 1target
Valproic acidHepatocyte growth factortarget
Valproic acidOrnithine decarboxylasetarget
Valproic acidProgrammed cell death 1 ligand 1target
Valproic acid4-aminobutyrate aminotransferase, mitochondrialtarget
Valproic acidGlycogen synthase kinase-3 alphatarget
LamotrigineVoltage-gated sodium channel alpha subunittarget
LamotrigineUDP-glucuronosyltransferases (UGTs)enzyme
LamotrigineATP-dependent translocase ABCB1transporter
LamotrigineDihydrofolate reductaseenzyme
Lamotrigine5-hydroxytryptamine receptor 3Atarget
LamotrigineVoltage-dependent R-type calcium channel subunit alpha-1Etarget
LamotrigineAdenosine receptor A1target
LamotrigineAdenosine receptor A2atarget
LamotrigineAlpha-1A adrenergic receptortarget
LamotrigineAlpha-2A adrenergic receptortarget
LamotrigineBeta-1 adrenergic receptortarget
LamotrigineD(1) dopamine receptortarget
LamotrigineD(2) dopamine receptortarget
LamotrigineGABA(A) Receptortarget
LamotrigineGABA(A) Receptor Benzodiazepine Binding Sitetarget
LamotrigineHistamine H1 receptortarget
LamotrigineKappa-type opioid receptortarget
LamotrigineAcetylcholine receptor subunit alphatarget
Lamotrigine5-hydroxytryptamine receptor 2Atarget
LamotrigineSolute carrier family 22 member 2transporter
LamotrigineAlbumincarrier
LamotrigineSolute carrier family 22 member 1transporter
LamotrigineGlutamate receptor 1target
LamotrigineSodium channel protein type 11 subunit alphatarget
CarbamazepineVoltage-gated sodium channel alpha subunittarget
CarbamazepineCytochrome P450 2C8enzyme
CarbamazepineCytochrome P450 2B6enzyme
CarbamazepineCytochrome P450 3A4enzyme
CarbamazepineCytochrome P450 1A2enzyme
CarbamazepineCytochrome P450 2C19enzyme
CarbamazepineCytochrome P450 2C9enzyme
CarbamazepineATP-dependent translocase ABCB1transporter
CarbamazepineCytochrome P450 3A5enzyme
CarbamazepineUDP-glucuronosyltransferase 2B7enzyme
CarbamazepineRalA-binding protein 1transporter
CarbamazepineATP-binding cassette sub-family C member 2transporter
CarbamazepineNeuronal acetylcholine receptor subunit alpha-4target
CarbamazepineNuclear receptor subfamily 1 group I member 2target
CarbamazepineUDP-glucuronosyltransferase 1A1enzyme
CarbamazepineUDP-glucuronosyltransferase 1-6enzyme
CarbamazepineUDP-glucuronosyltransferase 1A7enzyme
Magnesium sulfateVoltage-dependent L-type calcium channeltarget
OxcarbazepineCytochrome P450 2C19enzyme
OxcarbazepineCytochrome P450 3A4enzyme
OxcarbazepineCytochrome P450 3A5enzyme
OxcarbazepineAlbumincarrier
OxcarbazepineATP-dependent translocase ABCB1transporter
OxcarbazepineAldo-keto reductase family 1 member C1enzyme
OxcarbazepineAldo-keto reductase family 1 member C2enzyme
OxcarbazepineAldo-keto reductase family 1 member C3enzyme
OxcarbazepineAldo-keto reductase family 1 member C4enzyme
OxcarbazepineCarbonyl reductase [NADPH] 1enzyme
OxcarbazepineCarbonyl reductase [NADPH] 3enzyme
OxcarbazepineSodium channel proteintarget
OxcarbazepineSodium channel protein type 11 subunit alphatarget
GabapentinAdenosine receptor A1target
GabapentinVoltage-dependent calcium channel subunit alpha-2/delta-1target
GabapentinVoltage-dependent calcium channel subunit alpha-2/delta-2target
GabapentinBranched-chain-amino-acid aminotransferase, cytosolicenzyme
GabapentinLarge neutral amino acids transporter small subunit 1transporter
GabapentinVoltage-dependent N-type calcium channeltarget
GabapentinPotassium voltage-gated channel subfamily KQT member 3target
GabapentinPotassium voltage-gated channel subfamily KQT member 5target
GabapentinGamma-aminobutyric acid type B receptor subunit 1target
GabapentinGamma-aminobutyric acid type B receptor subunit 2target
Vigabatrin4-aminobutyrate aminotransferase, mitochondrialtarget
VigabatrinProton-coupled amino acid transporter 1transporter
VigabatrinCytochrome P450 2C9enzyme
LevetiracetamSynaptic vesicle glycoprotein 2Atarget
LevetiracetamATP-dependent translocase ABCB1transporter
LevetiracetamVoltage-dependent N-type calcium channel subunit alpha-1Btarget
Levetiracetam5-hydroxytryptamine receptor 3Atarget
BrivaracetamSynaptic vesicle glycoprotein 2Atarget
BrivaracetamSodium channel proteintarget
BrivaracetamCytochrome P450 3A4enzyme
BrivaracetamCytochrome P450 2C19enzyme
BrivaracetamCytochrome P450 2B6enzyme
BrivaracetamCytochrome P450 2C9enzyme
RufinamideMetabotropic glutamate receptor 5target
RufinamideLiver carboxylesterase 1enzyme
RufinamideSodium channel protein type 9 subunit alphatarget
RufinamideAlbumincarrier
RufinamideCytochrome P450 2E1enzyme
RufinamideCytochrome P450 3A4enzyme
LacosamideSodium channel protein type 9 subunit alphatarget
LacosamideSodium channel protein type 3 subunit alphatarget
LacosamideSodium channel protein type 10 subunit alphatarget
LacosamideCytochrome P450 2C19enzyme
LacosamideCytochrome P450 2C9enzyme
LacosamideCytochrome P450 3A4enzyme
LacosamideDihydropyrimidinase-related protein 2target
LacosamideSodium channel protein type 11 subunit alphatarget
PerampanelGlutamate receptor 1target
PerampanelCytochrome P450 3A4enzyme
PerampanelCytochrome P450 3A5enzyme
PerampanelCytochrome P450 1A2enzyme
PerampanelCytochrome P450 2B6enzyme
PerampanelGlutamate receptor 2target
PerampanelGlutamate receptor 3target
PerampanelGlutamate receptor 4target
StiripentolCytochrome P450 2C19enzyme
StiripentolCytochrome P450 2D6enzyme
StiripentolCytochrome P450 3A4enzyme
StiripentolCytochrome P450 1A2enzyme
StiripentolCytochrome P450 2C9enzyme
StiripentolGABA(A) Receptortarget
StiripentolL-lactate dehydrogenase A chaintarget
StiripentolL-lactate dehydrogenase B chaintarget
StiripentolCytochrome P450 2B6enzyme
StiripentolCytochrome P450 2C8enzyme
StiripentolATP-dependent translocase ABCB1transporter
StiripentolBroad substrate specificity ATP-binding cassette transporter ABCG2transporter
StiripentolGamma-aminobutyric acid receptor subunit gamma-3target