Rufinamide

DB06201ApprovedSmall moleculeAnticonvulsantsMiscellaneous Anticonvulsants

Rufinamide is an antiepileptic drug used as adjunctive therapy to treat seizures associated with Lennox-Gastaut Syndrome (LGS). Rufinamide is a triazole derivative and an anticonvulsant medication to treat seizure disorders like Lennox-Gastuat syndrome, a form of childhood epilepsy.

Chemical structure of Rufinamide
Mechanism
Curator reviewed
Primary indication
Adjunct therapy for treatment of seizures associated with Lennox-Gastaut syndrome.Curator reviewed · 1 structured indication
Formula / weight
C10H8F2N4O · 238.1935 g/mol (avg)
First approval
Canada, 2011 · United States, 2008 · European Union, 2016
Also known as
Xilep
Code names
CGP 33101 · E-2080 · RUF 331
Brand names
  • Banzel
  • Inovelon

Resolves to

Compound
UNIIWFW942PR79CAS106308-44-5ChEMBLCHEMBL1201754ChEBI134966PubChem129228KEGGD05775
Clinical / RWD
RxNorm69036ATCN03AF03PharmGKBPA166131606
Structure
InChIKeyPOGQSBRIGCQNEG-UHFFFAOYSA-NSMILESNC(=O)C1=CN(CC2=C(F)C=CC=C2F)N=N1
Targets
Q15858SCN9AP41594GRM5

What you can answer from here — as of June 15, 2026

3Protein targetsEach mapped to UniProt, with action and pharmacological action
Listed above
953Drug interactionsStructured to mechanism, not free text
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12Clinical trialsPhase, status and sponsor resolved per trial
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1Structured indicationCondition, population, route and combination as fields, not prose
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1ContraindicationEach with its own population and attribute set
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91Marketed productsAcross 9 countries and 17 labellers
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1ATC codeIncluding every combination product, plus 18 drug categories
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11+ReferencesStructured and connected to the statements they support
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Which drugs share a target with Rufinamide, and which of those have an active Phase 3 trial?

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