Cytochrome P-450 CYP3A5 Inhibitors (moderate)

Name
Cytochrome P-450 CYP3A5 Inhibitors (moderate)
Accession Number
DBCAT003809
Description

Not Available

Drugs
DrugDrug Description
IsavuconazoleIndicated for patients 18 years of age and older for the treatment of invasive aspergillosis [FDA Label]. Indicated for patients 18 years of age and older for the treatment of...
VerapamilA non-dihydropyridine calcium channel blocker used in the treatment of angina, arrhythmia, and hypertension.
CiprofloxacinA second generation fluoroquinolone used to treat various susceptible bacterial infections.
DiltiazemA calcium channel blocker used to treat hypertension and to manage chronic stable angina.
ErythromycinA macrolide antibiotic used to treat and prevent a variety of bacterial infections.
Drugs & Drug Targets
DrugTargetType
IsavuconazoleCytochrome P450 3A4enzyme
IsavuconazoleCytochrome P450 3A5enzyme
IsavuconazoleCytochrome P450 2C8enzyme
IsavuconazoleCytochrome P450 2C9enzyme
IsavuconazoleCytochrome P450 2C19enzyme
IsavuconazoleCytochrome P450 2D6enzyme
IsavuconazoleCytochrome P450 2B6enzyme
IsavuconazoleUDP-glucuronosyltransferase 1A9enzyme
IsavuconazoleUDP-glucuronosyltransferase 1A8enzyme
IsavuconazoleATP-dependent translocase ABCB1transporter
IsavuconazoleBroad substrate specificity ATP-binding cassette transporter ABCG2transporter
IsavuconazoleSolute carrier family 22 member 2transporter
IsavuconazoleLanosterol 14-alpha demethylasetarget
IsavuconazolePotassium voltage-gated channel subfamily H member 2target
IsavuconazoleVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
IsavuconazoleG protein-activated inward rectifier potassium channel 2target
IsavuconazoleG protein-activated inward rectifier potassium channel 3target
IsavuconazoleATP-sensitive inward rectifier potassium channel 11target
IsavuconazolePotassium voltage-gated channel subfamily A member 5target
IsavuconazoleA-type voltage-gated potassium channel KCND3target
IsavuconazolePotassium voltage-gated channel subfamily KQT member 1target
IsavuconazoleSodium channel protein type 5 subunit alphatarget
VerapamilATP-sensitive inward rectifier potassium channel 11target
VerapamilVoltage-dependent T-type calcium channel subunit alpha-1Gtarget
VerapamilPotassium voltage-gated channel subfamily H member 2target
VerapamilVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
VerapamilCytochrome P450 1A2enzyme
VerapamilCytochrome P450 3A5enzyme
VerapamilVoltage-dependent N-type calcium channel subunit alpha-1Btarget
VerapamilVoltage-dependent P/Q-type calcium channel subunit alpha-1Atarget
VerapamilSodium-dependent serotonin transportertarget
VerapamilCytochrome P450 3A4enzyme
VerapamilATP-dependent translocase ABCB1transporter
VerapamilSolute carrier family 22 member 1transporter
VerapamilATP-binding cassette sub-family C member 3transporter
VerapamilATP-binding cassette sub-family C member 4transporter
VerapamilOrganic cation/carnitine transporter 2transporter
VerapamilSolute carrier organic anion transporter family member 1A2transporter
VerapamilATP-binding cassette sub-family C member 10transporter
VerapamilSolute carrier family 22 member 4transporter
VerapamilSolute carrier organic anion transporter family member 1B1transporter
VerapamilCytochrome P450 2C8enzyme
VerapamilCytochrome P450 2C9enzyme
VerapamilCytochrome P450 2B6enzyme
VerapamilCytochrome P450 2C19enzyme
VerapamilCytochrome P450 2D6enzyme
VerapamilAlpha-1A adrenergic receptortarget
VerapamilAlpha-1B adrenergic receptortarget
VerapamilAlpha-1D adrenergic receptortarget
VerapamilAlbumincarrier
VerapamilAlpha-1-acid glycoprotein 1carrier
VerapamilCytochrome P450 2C18enzyme
VerapamilCytochrome P450 2E1enzyme
VerapamilMultidrug resistance-associated protein 1transporter
VerapamilMultidrug and toxin extrusion protein 1transporter
VerapamilMultidrug and toxin extrusion protein 2transporter
VerapamilVoltage-dependent T-type calcium channel subunit alpha-1Htarget
VerapamilVoltage-dependent calcium channeltarget
VerapamilATP-dependent translocase ABCB1target
CiprofloxacinDNA gyrase subunit Atarget
CiprofloxacinDNA topoisomerase 4 subunit Atarget
CiprofloxacinDNA topoisomerase 2-alphatarget
CiprofloxacinCytochrome P450 1A2enzyme
CiprofloxacinCytochrome P450 3A4enzyme
CiprofloxacinCytochrome P450 3A5enzyme
CiprofloxacinCytochrome P450 3A7enzyme
CiprofloxacinATP-dependent translocase ABCB1transporter
CiprofloxacinPotassium voltage-gated channel subfamily H member 2target
CiprofloxacinDNA gyrase subunit Atarget
CiprofloxacinDNA topoisomerase 4 subunit Atarget
CiprofloxacinDNA topoisomerase 4 subunit Btarget
CiprofloxacinDNA gyrase subunit Atarget
CiprofloxacinMultidrug resistance protein MdtKtarget
CiprofloxacinGyrase Atarget
CiprofloxacinDNA gyrase subunit Atarget
CiprofloxacinMultidrug and toxin extrusion protein 1transporter
CiprofloxacinMultidrug and toxin extrusion protein 2transporter
CiprofloxacinAlbumincarrier
CiprofloxacinThymidylate synthasetarget
CiprofloxacinDNA gyrase subunit Btarget
DiltiazemVoltage-dependent calcium channel gamma-1 subunittarget
DiltiazemCytochrome P450 3A4enzyme
DiltiazemCytochrome P450 2C19enzyme
DiltiazemCytochrome P450 2D6enzyme
DiltiazemCytochrome P450 3A5enzyme
DiltiazemCytochrome P450 3A7enzyme
DiltiazemATP-dependent translocase ABCB1transporter
DiltiazemCytochrome P450 2C8enzyme
DiltiazemAlbumincarrier
DiltiazemAlpha-1-acid glycoprotein 1carrier
DiltiazemVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
DiltiazemVoltage-dependent calcium channel subunit alpha-2/delta-1target
Erythromycin23S ribosomal RNAtarget
ErythromycinCytochrome P450 3A4enzyme
ErythromycinCytochrome P450 3A7enzyme
ErythromycinATP-dependent translocase ABCB1transporter
ErythromycinSolute carrier organic anion transporter family member 1B1transporter
ErythromycinMotilin receptortarget
ErythromycinPotassium voltage-gated channel subfamily H member 2target
ErythromycinCytochrome P450 3A5enzyme
ErythromycinSolute carrier organic anion transporter family member 1B3transporter
ErythromycinBile salt export pumptransporter
ErythromycinATP-binding cassette sub-family C member 2transporter
ErythromycinSolute carrier organic anion transporter family member 1A2transporter