UGT1A1 Inducers

Name

UGT1A1 Inducers

Accession Number

DBCAT003925

Description

Not Available

Drugs

Drug	Drug Description
Carbamazepine	An anticonvulsant used to treat various types of seizures and pain resulting from trigeminal neuralgia.
Phenytoin	An anticonvulsant drug used in the prophylaxis and control of various types of seizures.
Phenobarbital	A long-lasting barbiturate and anticonvulsant used in the treatment of all types of seizures, except for absent seizures.
Tipranavir	A protease inhibitor used to treat HIV-1 resistant to more than 1 protease inhibitor.
Rifampicin	An antibiotic used to treat several types of mycobacterial infections including Mycobacterium avium complex, leprosy, and in combination with other antibacterials to treat latent or active tuberculosis.
Testosterone propionate	A slow-release anabolic steroid no longer used commonly for the treatment of androgen deficiency or promotion of anabolic effects on muscles.
Nelfinavir	A viral protease inhibitor used in the treatment of HIV infection.
Ritonavir	An HIV protease inhibitor used in combination with other antivirals in the treatment of HIV infection.
Efavirenz	A non-nucleoside reverse transcriptase inhibitor used to treat HIV infection or prevent the spread of HIV.
Lamotrigine	A phenyltriazine antiepileptic used to treat some types of epilepsy and bipolar I disorder.
Primidone	An antiepileptic used to treat grand mal, psychomotor, and focal epileptic seizures.
Zidovudine	A dideoxynucleoside used in the treatment of HIV infection.
Ethinylestradiol	An estradiol used as a contraceptive.
Desogestrel	A synthetic progestin used in contraception, often in combination with ethinyl estradiol.
Mitapivat	A pyruvate kinase activator used to treat hemolytic anemia in adults with pyruvate kinase (PK) deficiency.
Vadadustat	An oral hypoxia-inducible factor prolyl-hydroxylase inhibitor used to treat symptomatic anemia associated with chronic kidney disease in adults on chronic maintenance dialysis.
Momelotinib	A Janus Kinase inhibitor used to treat intermediate or high-risk myelofibrosis.

Drugs & Drug Targets

Drug	Target	Type
Carbamazepine	Voltage-gated sodium channel alpha subunit	target
Carbamazepine	Cytochrome P450 2C8	enzyme
Carbamazepine	Cytochrome P450 2B6	enzyme
Carbamazepine	Cytochrome P450 3A4	enzyme
Carbamazepine	Cytochrome P450 1A2	enzyme
Carbamazepine	Cytochrome P450 2C19	enzyme
Carbamazepine	Cytochrome P450 2C9	enzyme
Carbamazepine	P-glycoprotein 1	transporter
Carbamazepine	Cytochrome P450 3A5	enzyme
Carbamazepine	UDP-glucuronosyltransferase 2B7	enzyme
Carbamazepine	RalA-binding protein 1	transporter
Carbamazepine	Canalicular multispecific organic anion transporter 1	transporter
Carbamazepine	Neuronal acetylcholine receptor subunit alpha-4	target
Carbamazepine	Nuclear receptor subfamily 1 group I member 2	target
Carbamazepine	UDP-glucuronosyltransferase 1-1	enzyme
Carbamazepine	UDP-glucuronosyltransferase 1-6	enzyme
Carbamazepine	UDP-glucuronosyltransferase 1-7	enzyme
Phenytoin	Sodium channel protein type 5 subunit alpha	target
Phenytoin	Sodium channel protein type 1 subunit alpha	target
Phenytoin	Cytochrome P450 2C8	enzyme
Phenytoin	Cytochrome P450 2C19	enzyme
Phenytoin	Cytochrome P450 2C9	enzyme
Phenytoin	Cytochrome P450 2B6	enzyme
Phenytoin	Cytochrome P450 3A5	enzyme
Phenytoin	Serum albumin	carrier
Phenytoin	Cytochrome P450 3A4	enzyme
Phenytoin	Solute carrier organic anion transporter family member 1C1	transporter
Phenytoin	P-glycoprotein 1	transporter
Phenytoin	Canalicular multispecific organic anion transporter 1	transporter
Phenytoin	Cytochrome P450 11B1, mitochondrial	enzyme
Phenytoin	Cytochrome P450 3A7	enzyme
Phenytoin	Nuclear receptor subfamily 1 group I member 2	target
Phenytoin	Sodium channel subunit beta-1	target
Phenytoin	Sodium channel protein type 3 subunit alpha	target
Phenytoin	UDP-glucuronosyltransferase 1-1	enzyme
Phenytoin	UDP-glucuronosyltransferase 1-6	enzyme
Phenytoin	UDP-glucuronosyltransferase 1-9	enzyme
Phenytoin	Thyroxine-binding globulin	carrier
Phenytoin	Potassium voltage-gated channel subfamily H member 2	target
Phenytoin	Voltage-dependent L-type calcium channel	target
Phenytoin	Sodium channel protein type 2 subunit alpha	target
Phenytoin	Sodium channel protein type 8 subunit alpha	target
Phenytoin	GABA(A) Receptor	target
Phenytoin	Cytochrome P450 1A2	enzyme
Phenytoin	Cytochrome P450 2A6	enzyme
Phenytoin	Cytochrome P450 2D6	enzyme
Phenytoin	Cytochrome P450 2E1	enzyme
Phenytoin	Epoxide hydrolase 1	enzyme
Phenytoin	UDP-glucuronosyltransferase 1-4	enzyme
Phenytoin	Catechol O-methyltransferase	enzyme
Phenytoin	NAD(P)H dehydrogenase [quinone] 1	enzyme
Phenytoin	Cytochrome P450 2C18	enzyme
Phenobarbital	Gamma-aminobutyric acid receptor subunit alpha-1	target
Phenobarbital	Cytochrome P450 2C19	enzyme
Phenobarbital	Cytochrome P450 2C9	enzyme
Phenobarbital	Cytochrome P450 2B6	enzyme
Phenobarbital	Cytochrome P450 2C8	enzyme
Phenobarbital	Cytochrome P450 1A2	enzyme
Phenobarbital	Cytochrome P450 3A4	enzyme
Phenobarbital	Canalicular multispecific organic anion transporter 2	transporter
Phenobarbital	Bile salt export pump	transporter
Phenobarbital	P-glycoprotein 1	transporter
Phenobarbital	Multidrug resistance-associated protein 1	transporter
Phenobarbital	Solute carrier organic anion transporter family member 2A1	transporter
Phenobarbital	Canalicular multispecific organic anion transporter 1	transporter
Phenobarbital	Neuronal acetylcholine receptor subunit alpha-4	target
Phenobarbital	Neuronal acetylcholine receptor subunit alpha-7	target
Phenobarbital	Glutamate receptor 2	target
Phenobarbital	Glutamate receptor ionotropic, kainate 2	target
Phenobarbital	Cytochrome P450 2A6	enzyme
Phenobarbital	Cytochrome P450 2E1	enzyme
Phenobarbital	Cytochrome P450 3A5	enzyme
Phenobarbital	Cytochrome P450 1A1	enzyme
Phenobarbital	Cytochrome P450 2C18	enzyme
Phenobarbital	Cytochrome P450 3A7	enzyme
Phenobarbital	Cytochrome P450 4B1	enzyme
Phenobarbital	NMDA receptor	target
Phenobarbital	Nuclear receptor subfamily 1 group I member 2	target
Phenobarbital	UDP-glucuronosyltransferase 1-1	enzyme
Phenobarbital	UDP-glucuronosyltransferase 2B7	enzyme
Tipranavir	Human immunodeficiency virus type 1 protease	target
Tipranavir	Cytochrome P450 3A4	enzyme
Tipranavir	Cytochrome P450 2D6	enzyme
Tipranavir	Cytochrome P450 2C19	enzyme
Tipranavir	Bile salt export pump	transporter
Tipranavir	UDP-glucuronosyltransferase 1-1	enzyme
Tipranavir	Solute carrier organic anion transporter family member 2B1	transporter
Tipranavir	Solute carrier organic anion transporter family member 1B1	transporter
Tipranavir	Solute carrier organic anion transporter family member 1B3	transporter
Tipranavir	P-glycoprotein 1	transporter
Rifampicin	DNA-directed RNA polymerase subunit beta	target
Rifampicin	Nuclear receptor subfamily 1 group I member 2	target
Rifampicin	Cytochrome P450 3A4	enzyme
Rifampicin	Cytochrome P450 1A2	enzyme
Rifampicin	Cytochrome P450 2C8	enzyme
Rifampicin	UDP-glucuronosyltransferase 1-1	enzyme
Rifampicin	Cytochrome P450 2C9	enzyme
Rifampicin	Cytochrome P450 2B6	enzyme
Rifampicin	Cytochrome P450 2C19	enzyme
Rifampicin	Canalicular multispecific organic anion transporter 2	transporter
Rifampicin	Multidrug resistance-associated protein 5	transporter
Rifampicin	P-glycoprotein 1	transporter
Rifampicin	Canalicular multispecific organic anion transporter 1	transporter
Rifampicin	Solute carrier organic anion transporter family member 2B1	transporter
Rifampicin	Bile salt export pump	transporter
Rifampicin	Multidrug resistance-associated protein 1	transporter
Rifampicin	Solute carrier organic anion transporter family member 1A2	transporter
Rifampicin	Solute carrier organic anion transporter family member 1B3	transporter
Rifampicin	Solute carrier family 22 member 7	transporter
Rifampicin	Solute carrier organic anion transporter family member 1B1	transporter
Rifampicin	Cytochrome P450 2A6	enzyme
Rifampicin	Cytochrome P450 2E1	enzyme
Rifampicin	Cytochrome P450 3A43	enzyme
Rifampicin	Cytochrome P450 3A7	enzyme
Rifampicin	Solute carrier family 22 member 6	transporter
Rifampicin	Solute carrier family 22 member 8	transporter
Rifampicin	UDP-glucuronosyltransferase 1-9	enzyme
Rifampicin	Cytochrome P450 3A5	enzyme
Rifampicin	Serum albumin	carrier
Rifampicin	alpha1-acid glycoprotein	carrier
Testosterone propionate	Androgen receptor	target
Testosterone propionate	Catechol O-methyltransferase	enzyme
Testosterone propionate	UDP-glucuronosyltransferase 1-1	enzyme
Testosterone propionate	3-oxo-5-alpha-steroid 4-dehydrogenase	enzyme
Testosterone propionate	Cytochrome P450 3A4	enzyme
Testosterone propionate	P-glycoprotein 1	transporter
Testosterone propionate	Sex hormone-binding globulin	carrier
Testosterone propionate	Serum albumin	carrier
Nelfinavir	HIV-1 protease	target
Nelfinavir	Cytochrome P450 2C19	enzyme
Nelfinavir	Cytochrome P450 3A4	enzyme
Nelfinavir	Cytochrome P450 2B6	enzyme
Nelfinavir	Cytochrome P450 3A5	enzyme
Nelfinavir	Cytochrome P450 3A7	enzyme
Nelfinavir	P-glycoprotein 1	transporter
Nelfinavir	Solute carrier family 22 member 1	transporter
Nelfinavir	Solute carrier organic anion transporter family member 1A2	transporter
Nelfinavir	ATP-binding cassette sub-family G member 2	transporter
Nelfinavir	Solute carrier organic anion transporter family member 1B1	transporter
Nelfinavir	Cytochrome P450 2D6	enzyme
Nelfinavir	Serum albumin	carrier
Nelfinavir	UDP-glucuronosyltransferase 1-1	enzyme
Nelfinavir	Solute carrier organic anion transporter family member 1B3	transporter
Nelfinavir	Solute carrier organic anion transporter family member 2B1	transporter
Nelfinavir	Bile salt export pump	transporter
Nelfinavir	Cytochrome P450 2C9	enzyme
Nelfinavir	Alpha-1-acid glycoprotein 1	carrier
Ritonavir	Human immunodeficiency virus type 1 protease	target
Ritonavir	Cytochrome P450 2D6	enzyme
Ritonavir	Cytochrome P450 2C9	enzyme
Ritonavir	Cytochrome P450 2C19	enzyme
Ritonavir	Cytochrome P450 2B6	enzyme
Ritonavir	Cytochrome P450 2C8	enzyme
Ritonavir	P-glycoprotein 1	transporter
Ritonavir	Multidrug resistance-associated protein 1	transporter
Ritonavir	Canalicular multispecific organic anion transporter 1	transporter
Ritonavir	Solute carrier organic anion transporter family member 1A2	transporter
Ritonavir	ATP-binding cassette sub-family G member 2	transporter
Ritonavir	Solute carrier organic anion transporter family member 1B1	transporter
Ritonavir	Cytochrome P450 1A2	enzyme
Ritonavir	Nuclear receptor subfamily 1 group I member 2	target
Ritonavir	Serum albumin	carrier
Ritonavir	Cytochrome P450 3A4	enzyme
Ritonavir	Cytochrome P450 3A5	enzyme
Ritonavir	Cytochrome P450 3A7	enzyme
Ritonavir	UDP-glucuronosyltransferases (UGTs)	enzyme
Ritonavir	Solute carrier organic anion transporter family member 2B1	transporter
Ritonavir	Bile salt export pump	transporter
Ritonavir	Alpha-1-acid glycoprotein 1	carrier
Ritonavir	Solute carrier organic anion transporter family member 1B3	transporter
Efavirenz	Cytochrome P450 2B6	enzyme
Efavirenz	Cytochrome P450 3A4	enzyme
Efavirenz	Cytochrome P450 2C19	enzyme
Efavirenz	Cytochrome P450 2C9	enzyme
Efavirenz	Cytochrome P450 1A2	enzyme
Efavirenz	Cytochrome P450 2D6	enzyme
Efavirenz	Reverse transcriptase/RNaseH	target
Efavirenz	Cytochrome P450 2C8	enzyme
Efavirenz	Serum albumin	carrier
Efavirenz	Cytochrome P450 3A5	enzyme
Efavirenz	Cytochrome P450 3A7	enzyme
Efavirenz	UDP-glucuronosyltransferase 1-1	enzyme
Efavirenz	Bile salt export pump	transporter
Efavirenz	Solute carrier family 22 member 1	transporter
Lamotrigine	Voltage-gated sodium channel alpha subunit	target
Lamotrigine	UDP-glucuronosyltransferases (UGTs)	enzyme
Lamotrigine	P-glycoprotein 1	transporter
Lamotrigine	Dihydrofolate reductase	enzyme
Lamotrigine	5-hydroxytryptamine receptor 3A	target
Lamotrigine	Voltage-dependent R-type calcium channel subunit alpha-1E (CACNA1E)	target
Lamotrigine	Adenosine receptor A1	target
Lamotrigine	Adenosine receptor A2a	target
Lamotrigine	Alpha-1A adrenergic receptor	target
Lamotrigine	Alpha-2A adrenergic receptor	target
Lamotrigine	Beta-1 adrenergic receptor	target
Lamotrigine	D(1) dopamine receptor	target
Lamotrigine	Dopamine D2 receptor	target
Lamotrigine	GABA(A) Receptor	target
Lamotrigine	GABA(A) Receptor Benzodiazepine Binding Site	target
Lamotrigine	Histamine H1 receptor	target
Lamotrigine	Kappa-type opioid receptor	target
Lamotrigine	Acetylcholine receptor subunit alpha	target
Lamotrigine	5-hydroxytryptamine receptor 2A	target
Lamotrigine	Solute carrier family 22 member 2	transporter
Lamotrigine	Serum albumin	carrier
Lamotrigine	Solute carrier family 22 member 1	transporter
Lamotrigine	Glutamate receptor 1	target
Primidone	Gamma-aminobutyric acid receptor subunit alpha-1	target
Primidone	Cytochrome P450 2C19	enzyme
Primidone	Cytochrome P450 2C9	enzyme
Primidone	Cytochrome P450 3A4	enzyme
Primidone	Gamma-aminobutyric acid receptor subunit alpha-2	target
Primidone	Gamma-aminobutyric acid receptor subunit alpha-3	target
Primidone	Gamma-aminobutyric acid receptor subunit alpha-4	target
Primidone	Gamma-aminobutyric acid receptor subunit alpha-5	target
Primidone	Gamma-aminobutyric acid receptor subunit alpha-6	target
Primidone	Neuronal acetylcholine receptor subunit alpha-4	target
Primidone	Neuronal acetylcholine receptor subunit alpha-7	target
Primidone	Glutamate receptor 2	target
Primidone	Glutamate receptor ionotropic, kainate 2	target
Primidone	GABA(A) Receptor	target
Primidone	Transient receptor potential cation channel subfamily M member 3	transporter
Primidone	Cytochrome P450 2E1	enzyme
Primidone	Cytochrome P450 1A2	enzyme
Primidone	UDP-glucuronosyltransferases (UGTs)	enzyme
Zidovudine	Serum albumin	carrier
Zidovudine	Cytochrome P450 2A6	enzyme
Zidovudine	Cytochrome P450 2C9	enzyme
Zidovudine	Cytochrome P450 3A4	enzyme
Zidovudine	Reverse transcriptase/RNaseH	target
Zidovudine	Solute carrier family 22 member 2	transporter
Zidovudine	Solute carrier family 22 member 6	transporter
Zidovudine	Solute carrier family 22 member 7	transporter
Zidovudine	Solute carrier family 22 member 8	transporter
Zidovudine	Solute carrier family 22 member 11	transporter
Zidovudine	Sodium/nucleoside cotransporter 1	transporter
Zidovudine	Equilibrative nucleoside transporter 2	transporter
Zidovudine	P-glycoprotein 1	transporter
Zidovudine	Multidrug resistance-associated protein 4	transporter
Zidovudine	Multidrug resistance-associated protein 5	transporter
Zidovudine	ATP-binding cassette sub-family G member 2	transporter
Zidovudine	Telomerase reverse transcriptase	target
Zidovudine	Thymidine kinase, cytosolic	enzyme
Zidovudine	UDP-glucuronosyltransferase 2B7	enzyme
Zidovudine	UDP-glucuronosyltransferase 1-1	enzyme
Ethinylestradiol	Estrogen receptor alpha	target
Ethinylestradiol	Nuclear receptor subfamily 1 group I member 2	target
Ethinylestradiol	Cytochrome P450 3A4	enzyme
Ethinylestradiol	Cytochrome P450 2C8	enzyme
Ethinylestradiol	Bile salt export pump	transporter
Ethinylestradiol	Sodium/bile acid cotransporter	transporter
Ethinylestradiol	Canalicular multispecific organic anion transporter 1	transporter
Ethinylestradiol	P-glycoprotein 1	transporter
Ethinylestradiol	UDP-glucuronosyltransferase 1-1	enzyme
Ethinylestradiol	Cytochrome P450 2C19	enzyme
Ethinylestradiol	UDP-glucuronosyltransferase 1-4	enzyme
Ethinylestradiol	UDP-glucuronosyltransferase 1-9	enzyme
Ethinylestradiol	Cytochrome P450 2C9	enzyme
Ethinylestradiol	Cytochrome P450 1A2	enzyme
Ethinylestradiol	Estrogen sulfotransferase	enzyme
Ethinylestradiol	Sulfotransferase 1A3/1A4	enzyme
Ethinylestradiol	Cytochrome P450 3A5	enzyme
Ethinylestradiol	UDP-glucuronosyltransferase 2B7	enzyme
Ethinylestradiol	UDP-glucuronosyltransferase 1-3	enzyme
Ethinylestradiol	Catechol O-methyltransferase	enzyme
Ethinylestradiol	Solute carrier organic anion transporter family member 1A2	transporter
Ethinylestradiol	Serum albumin	carrier
Ethinylestradiol	Sex hormone-binding globulin	carrier
Desogestrel	Progesterone receptor	target
Desogestrel	Estrogen receptor alpha	target
Desogestrel	Cytochrome P450 3A4	enzyme
Desogestrel	Serum albumin	carrier
Desogestrel	Sex hormone-binding globulin	carrier
Desogestrel	Cytochrome P450 2C9	enzyme
Desogestrel	UDP-glucuronosyltransferase 1-1	enzyme
Mitapivat	Cytochrome P450 3A4	enzyme
Mitapivat	Cytochrome P450 2B6	enzyme
Mitapivat	Cytochrome P450 2C8	enzyme
Mitapivat	Cytochrome P450 2C9	enzyme
Mitapivat	Cytochrome P450 2C19	enzyme
Mitapivat	UDP-glucuronosyltransferase 1-1	enzyme
Mitapivat	P-glycoprotein 1	transporter
Mitapivat	Cytochrome P450 1A2	enzyme
Mitapivat	Pyruvate kinase PKLR	target
Mitapivat	Cytochrome P450 19A1	target
Vadadustat	Egl nine homolog 2	target
Vadadustat	Egl nine homolog 3	target
Vadadustat	Egl nine homolog 1	target
Vadadustat	Hypoxia-inducible factor 1-alpha	target
Vadadustat	Endothelial PAS domain-containing protein 1	target
Vadadustat	UDP-glucuronosyltransferase 1-1	enzyme
Vadadustat	UDP-glucuronosyltransferase 1-7	enzyme
Vadadustat	UDP-glucuronosyltransferase 1-8	enzyme
Vadadustat	UDP-glucuronosyltransferase 1-9	enzyme
Vadadustat	UDP-glucuronosyltransferase 2B7	enzyme
Vadadustat	Cytochrome P450 2B6	enzyme
Vadadustat	Cytochrome P450 2C8	enzyme
Vadadustat	Cytochrome P450 3A4	enzyme
Vadadustat	ATP-binding cassette sub-family G member 2	transporter
Vadadustat	Solute carrier family 22 member 8	transporter
Vadadustat	Solute carrier family 22 member 6	transporter
Vadadustat	Serum albumin	carrier
Vadadustat	Cytochrome P450 2C9	enzyme
Momelotinib	Cytochrome P450 3A4	enzyme
Momelotinib	Cytochrome P450 2C8	enzyme
Momelotinib	Cytochrome P450 2C9	enzyme
Momelotinib	Cytochrome P450 2C19	enzyme
Momelotinib	Cytochrome P450 1A2	enzyme
Momelotinib	Cytochrome P450 2B6	enzyme
Momelotinib	UDP-glucuronosyltransferase 1-1	enzyme
Momelotinib	UDP-glucuronosyltransferase 1-9	enzyme
Momelotinib	P-glycoprotein 1	transporter
Momelotinib	ATP-binding cassette sub-family G member 2	transporter
Momelotinib	Solute carrier organic anion transporter family member 1B1	transporter
Momelotinib	Solute carrier organic anion transporter family member 1B3	transporter
Momelotinib	Tyrosine-protein kinase JAK1	target
Momelotinib	Tyrosine-protein kinase JAK2	target
Momelotinib	Tyrosine-protein kinase JAK3	target
Momelotinib	Non-receptor tyrosine-protein kinase TYK2	target
Momelotinib	Activin receptor type-1	target
Momelotinib	Receptor-type tyrosine-protein kinase FLT3	target