Kallikrein Inhibitors

Name

Kallikrein Inhibitors

Accession Number

DBCAT004400

Description

Not Available

Drugs

Drug	Drug Description
Human C1-esterase inhibitor	A C1 inhibitor used to prevent angioedema attacks associated with hereditary angioedema.
Ecallantide	A kallikrein inhibitor used to prevent and treat acute attacks caused by Hereditary Angioedema (HAE).
Berotralstat	An inhibitor of plasma kallikrein used for prophylaxis of angioedema attacks in patients with hereditary angioedema.
Lanadelumab	A monoclonal antibody targeted against kallikrein which is used to treat attacks of hereditary angioedema.

Drugs & Drug Targets

Drug	Target	Type
Human C1-esterase inhibitor	Complement C1r subcomponent	target
Human C1-esterase inhibitor	Complement C1s subcomponent	target
Human C1-esterase inhibitor	Plasma kallikrein	target
Human C1-esterase inhibitor	Coagulation factor XII	target
Human C1-esterase inhibitor	Prothrombin	target
Human C1-esterase inhibitor	Coagulation factor XI	target
Human C1-esterase inhibitor	Tissue-type plasminogen activator	target
Ecallantide	Plasma kallikrein	target
Berotralstat	Cytochrome P450 2D6	enzyme
Berotralstat	Cytochrome P450 3A4	enzyme
Berotralstat	P-glycoprotein 1	transporter
Berotralstat	ATP-binding cassette sub-family G member 2	transporter
Berotralstat	Plasma kallikrein	target
Lanadelumab	Plasma kallikrein	target