Glucosylceramide Synthase Inhibitors

Name
Glucosylceramide Synthase Inhibitors
Accession Number
DBCAT004429
Description

Not Available

Drugs
DrugDrug Description
MiglustatA glucosylceramide synthase inhibitor used for the management of mild to moderate type I Gaucher disease for patients who are not candidates for whole enzyme replacement.
EliglustatA glucosylceramide synthase used to treat type 1 Gaucher disease in patients who are CYP2D6 extensive, intermediate, or poor metabolizers.
Drugs & Drug Targets
DrugTargetType
MiglustatCeramide glucosyltransferasetarget
EliglustatCeramide glucosyltransferasetarget
EliglustatCytochrome P450 2D6enzyme
EliglustatCytochrome P450 3A4enzyme
EliglustatP-glycoprotein 1transporter