Pegylated agents

Name
Pegylated agents
Accession Number
DBCAT004540
Description

Not Available

Drugs
DrugDrug Description
Egaptivon pegolPlatelet aggregation, thrombosis and acute coronary syndromes
Lexaptepid pegolLexaptepid pegol has been used in trials studying the treatment of Anemia, Inflammation, Chronic Diseases, End Stage Renal Disease, and Anemia of Chronic Disease.
PeginesatidePeginesatide is used for the treatment of anemia due to chronic kidney disease (CKD) in adult patients on dialysis
LipegfilgrastimA medication used to reduce the duration of chemotherapy-induced neutropenia and incidence of febrile neutropenia in cytotoxic chemotherapy.
Abicipar PegolAbicipar Pegol has been used in trials studying the treatment of Macular Edema and Macular Degeneration.
ElapegademaseA recombinant adenosine deaminase used to treat adenosine deaminase severe combined immune deficiency.
PEG-uricaseInvestigated for use/treatment in hyperuricemia.
Antihemophilic factor (recombinant), PEGylatedFor the management of hemophilia A (congenital factor VIII deficiency) [FDA label], . This medication is a human antihemophilic factor indicated in adolescent and adult patients (12 years and older)...
Eptacog alfa pegol (activated)Eptacog alfa pegol (activated) has been used in trials studying the prevention and treatment of Haemophilia A, Haemophilia B, Congenital Bleeding Disorder, Haemophilia B With Inhibitors, and Haemophilia A With...
PegademaseA modified form of bovine adenosine deaminase used to treat adenosine deaminase deficiency, a condition which leads to the formation of adenosine metabolites which are cytotoxic to lymphocytes.
PegamotecanPegamotecan has been used in trials studying the treatment of Cancer of Stomach, Sarcoma, Soft Tissue, and Gastroesophageal Cancer.
Peginterferon beta-1aAn interferon beta used to treat relapsing forms of multiple sclerosis.
GlycoPEG-GCSFInvestigated for use/treatment in adverse effects (chemotherapy) and neutropenics.
PegaptanibA selective vascular endothelial growth factor (VEGF) antagonist used for the treatment of neovascular (wet) age-related macular degeneration.
PegloticaseA recombinant uricase used for the treatment of chronic gout in adult patients refractory to conventional therapy.
Certolizumab pegolA tumor necrosis factor (TNF) blocker used to treat a variety of autoimmune and autoinflammatory conditions like Crohn's disease, rheumatoid arthritis, active psoriatic arthritis, ankylosing spondylitis, axial spondyloarthritis, and plaque psoriasis.
PegnivacoginInvestigated for use/treatment in thrombosis, coronary artery disease, and vascular diseases.
Olaptesed PegolOlaptesed Pegol has been investigated for the treatment of Hematopoietic Stem Cell Transplantation.
PegpleranibInvestigated for use/treatment in macular degeneration and eye disorders/infections.
Heptaethylene glycolNot Annotated
Peg-100 stearateNot Annotated
PegsunerceptInvestigated for use/treatment in rheumatoid arthritis.
Damoctocog alfa pegolA recombinant Factor VIII used to treat hemophilia A to control bleeding, perioperative bleeding, and also for prophylaxis of bleeding.
Insulin peglisproNot Annotated
PegvaliaseAn enzyme used to treat phenylketonuria in patients with phenylalanine levels that are too high on current treatment.
Methoxy PEG-12 retinamideNot Annotated
Methoxy polyethylene glycol-epoetin betaA synthetic erythropoiesis stimulating agent (ESA) used to treat anemia associated with chronic kidney disease.
Cepeginterferon alfa-2BCepeginterferon alfa-2B is under investigation in clinical trial NCT01889433 (An Open-label Comparative Efficacy and Safety Study of Algeron (Cepeginterferon Alfa-2b) in Treatment-naive Patients With Chronic Hepatitis C).
Nonacog beta pegolA recombinant coagulation Factor IX derivative used to treat hemophilia B.
PegaspargaseA modified form of L-asparagine amidohydrolase used to treat acute lymphoblastic leukemia, which is dependent on an external source of asparagine.
PolidocanolA sclerosing agent used for the treatment of uncomplicated spider veins and uncomplicated reticular veins, all less than 3 mm in diameter, in the lower extremity.
Peginterferon alfa-2aA modified form of recombinant human interferon used to stimulate the innate antiviral response in the treatment of hepatitis B and C viruses.
Peginterferon alfacon-1Investigated for use/treatment in hepatitis (viral, C).
Peginterferon alfa-2bA purified form of human interferon used to stimulate the innate antiviral response in the treatment of hepatitis B and C, genital warts, and some cancers.
Propylene glycolA clear, colorless, viscous organic solvent and diluent used in pharmaceutical preparations.
Polyethylene glycolA laxative used to treat constipation and used for bowel preparation before colonoscopies and other procedures.
Polyethylene glycol 400An ingredient used in a wide variety of medications, and is not an approved medication.
PegvisomantA growth hormone receptor antagonist used to treat acromegaly.
PegfilgrastimA recombinant human granulocyte colony stimulating factor used to stimulate the production of neutrophils and prevent febrile neutropenia or infections after myelosuppressive chemotherapy.
Drugs & Drug Targets
DrugTargetType
Egaptivon pegolvon Willebrand factortarget
Egaptivon pegolPlatelet glycoprotein Ib alpha chaintarget
PeginesatideErythropoietin receptortarget
LipegfilgrastimGranulocyte colony-stimulating factor receptortarget
ElapegademaseAdenosinetarget
PEG-uricaseUric acid degradation bifunctional proteintarget
Antihemophilic factor (recombinant), PEGylatedvon Willebrand factortarget
Antihemophilic factor (recombinant), PEGylatedvon Willebrand factorcarrier
PegademaseAdenosinetarget
PegademaseGrowth factor receptor-bound protein 2target
Peginterferon beta-1aCytochrome P450 1A2enzyme
Peginterferon beta-1aInterferon alpha/beta receptor 1target
PegaptanibVascular endothelial growth factor Atarget
PegloticaseUric acidtarget
Certolizumab pegolTumor necrosis factortarget
Certolizumab pegolAlcohol dehydrogenase [NADP(+)]enzyme
PegpleranibPlatelet-derived growth factor subunit Btarget
Heptaethylene glycolCarbonyl reductase [NADPH] 1target
Damoctocog alfa pegolCoagulation factor VIIItarget
Insulin peglisproCytochrome P450 1A2enzyme
Insulin peglisproInsulin receptortarget
Insulin peglisproInsulin-like growth factor 1 receptortarget
Methoxy polyethylene glycol-epoetin betaErythropoietin receptortarget
Cepeginterferon alfa-2BCytochrome P450 1A2enzyme
Nonacog beta pegolCoagulation factor VIItarget
Nonacog beta pegolCoagulation factor VIIItarget
Nonacog beta pegolCoagulation factor Xtarget
PegaspargaseL-asparaginetarget
PegaspargaseThyroxine-binding globulincarrier
Peginterferon alfa-2aInterferon alpha/beta receptor 2target
Peginterferon alfa-2aInterferon alpha/beta receptor 1target
Peginterferon alfa-2aCytochrome P450 1A2enzyme
Peginterferon alfa-2bInterferon alpha/beta receptor 1target
Peginterferon alfa-2bInterferon alpha/beta receptor 2target
Peginterferon alfa-2bCytochrome P450 1A2enzyme
Peginterferon alfa-2bCytochrome P450 2D6enzyme
Peginterferon alfa-2bCytochrome P450 2C9enzyme
Propylene glycolB12-independent glycerol dehydratasetarget
Polyethylene glycolP-glycoprotein 1transporter
Polyethylene glycol 400Oxidoreductase HTATIP2target
Polyethylene glycol 400Cytochrome P450 4A11enzyme
Polyethylene glycol 400Alcohol dehydrogenase class-3enzyme
Polyethylene glycol 400Sulfotransferase 1A1enzyme
Polyethylene glycol 400Ectonucleotide pyrophosphatase/phosphodiesterase family member 1target
Polyethylene glycol 400P-glycoprotein 1transporter
PegvisomantGrowth hormone receptortarget
PegvisomantSterol 26-hydroxylase, mitochondrialenzyme
PegvisomantGlutamine synthetaseenzyme
PegvisomantCytochrome P450 3A4enzyme
PegvisomantCholinesteraseenzyme
PegvisomantCytochrome P450 4A11enzyme
PegfilgrastimGranulocyte colony-stimulating factor receptortarget
PegfilgrastimNeutrophil elastaseenzyme