Peginesatide is a synthetic peptide attached to polyethylene glycol for the treatment of anemia. The polyethylene glycol moiety helps make the drug less immunogenic and prolongs its plasma half-life. Chemically,... Chemically, peginesatide is designed to mimic the pharmacological activity of erythropoietin, but is not a replica of the structure itself.
- Mechanism
- Curator reviewed
Peginesatide binds to and activates the human erythropoietin receptor and stimulates erythropoiesis in human red cell precursors in vitro.
- Primary indication
- Peginesatide is used for the treatment of anemia due to chronic kidney disease (CKD) in adult patients on dialysisCurator reviewed
- First approval
- United States, 2012
- Also known as
- Hematide
- Code names
- AF-37702
Resolves to
Clinical / RWD
Targets
What you can answer from here — as of July 17, 2026
1Protein targetEach mapped to UniProt, with action and pharmacological actionListed above
Which drugs share a target with Peginesatide, and which of those have an active Phase 3 trial?
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