UGT1A3 Substrates with a Narrow Therapeutic Index

Name
UGT1A3 Substrates with a Narrow Therapeutic Index
Accession Number
DBCAT004612
Description

Not Available

Drugs
DrugDrug Description
Valproic acidAn anticonvulsant used to control complex partial seizures and both simple and complex absence seizures.
EnasidenibAn isocitrate dehydrogenase-2 inhibitor used to treat relapsed or refractory acute myeloid leukemia with an isocitrate dehydrogenase-2 mutation.
Drugs & Drug Targets
DrugTargetType
Valproic acidHistone deacetylase 9target
Valproic acidShort/branched chain specific acyl-CoA dehydrogenase, mitochondrialtarget
Valproic acidCytochrome P450 2A6enzyme
Valproic acidCytochrome P450 2B6enzyme
Valproic acidCytochrome P450 2C9enzyme
Valproic acidOrganic cation/carnitine transporter 2transporter
Valproic acidSolute carrier family 22 member 6transporter
Valproic acidOrganic anion transporter 3transporter
Valproic acidMonocarboxylate transporter 1transporter
Valproic acidSolute carrier family 22 member 7transporter
Valproic acidCytochrome P450 3A5enzyme
Valproic acidUDP-glucuronosyltransferase 1A9enzyme
Valproic acidProstaglandin G/H synthase 1enzyme
Valproic acidCytochrome P450 1A2enzyme
Valproic acidCytochrome P450 2C19enzyme
Valproic acidCytochrome P450 3A4enzyme
Valproic acidUDP-glucuronosyltransferase 1A4enzyme
Valproic acidUDP-glucuronosyltransferase 1A8enzyme
Valproic acidUDP-glucuronosyltransferase 1A10enzyme
Valproic acidUDP-glucuronosyltransferase 1-6enzyme
Valproic acidUDP-glucuronosyltransferase 1A3enzyme
Valproic acidUDP-glucuronosyltransferase 2B7enzyme
Valproic acidUDP-glucuronosyltransferase 2B15enzyme
Valproic acid2-oxoglutarate dehydrogenase complex component E1target
Valproic acidSuccinate-semialdehyde dehydrogenase, mitochondrialtarget
Valproic acidSodium channel proteintarget
Valproic acidHistone deacetylase 2target
Valproic acidPeroxisome proliferator-activated receptor alphatarget
Valproic acidPeroxisome proliferator-activated receptor deltatarget
Valproic acidPeroxisome proliferator-activated receptor gammatarget
Valproic acidAlbumincarrier
Valproic acidUDP-glucuronosyltransferase 1A1enzyme
Valproic acidSolute carrier organic anion transporter family member 2B1transporter
Valproic acidHistone deacetylasetarget
Valproic acidCyclin-dependent kinase inhibitor 1target
Valproic acidHepatocyte growth factortarget
Valproic acidOrnithine decarboxylasetarget
Valproic acidProgrammed cell death 1 ligand 1target
Valproic acid4-aminobutyrate aminotransferase, mitochondrialtarget
Valproic acidGlycogen synthase kinase-3 alphatarget
EnasidenibCytochrome P450 1A2enzyme
EnasidenibCytochrome P450 2B6enzyme
EnasidenibIsocitrate dehydrogenase [NADP], mitochondrialtarget
EnasidenibCytochrome P450 2C8enzyme
EnasidenibCytochrome P450 2C9enzyme
EnasidenibCytochrome P450 2C19enzyme
EnasidenibCytochrome P450 2D6enzyme
EnasidenibCytochrome P450 3A4enzyme
EnasidenibUDP-glucuronosyltransferase 1A1enzyme
EnasidenibUDP-glucuronosyltransferase 1A3enzyme
EnasidenibUDP-glucuronosyltransferase 1A4enzyme
EnasidenibUDP-glucuronosyltransferase 1A9enzyme
EnasidenibUDP-glucuronosyltransferase 2B7enzyme
EnasidenibUDP-glucuronosyltransferase 2B15enzyme
EnasidenibATP-dependent translocase ABCB1transporter
EnasidenibBroad substrate specificity ATP-binding cassette transporter ABCG2transporter
EnasidenibSolute carrier family 22 member 6transporter
EnasidenibSolute carrier organic anion transporter family member 1B1transporter
EnasidenibSolute carrier family 22 member 2transporter
EnasidenibSolute carrier organic anion transporter family member 1B3transporter
EnasidenibOrganic anion transporter 3transporter
EnasidenibAlbumincarrier
EnasidenibIsocitrate dehydrogenase [NADP] cytoplasmictarget
EnasidenibIsocitrate dehydrogenase [NAD] subunit alpha, mitochondrialtarget
EnasidenibIsocitrate dehydrogenase [NAD] subunit beta, mitochondrialtarget
EnasidenibIsocitrate dehydrogenase [NAD] subunit gamma, mitochondrialtarget