Calcitonin Gene-Related Peptide (CGRP) Antagonists

Name
Calcitonin Gene-Related Peptide (CGRP) Antagonists
Accession Number
DBCAT004663  (DBCAT005175)
Description

Not Available

ATC Classification
Drugs
DrugDrug Description
ErenumabA calcitonin-gene related peptide antagonist used to prevent migraines.
GalcanezumabA calcitonin-gene related peptide antagonist used to prevent migraines and treat cluster headaches.
EptinezumabA monoclonal antibody directed against CGRP infused every 3 months for the preventive treatment of migraine in adults.
ZavegepantA calcitonin gene-related peptide receptor antagonist indicated for the acute treatment of migraine with or without aura.
FremanezumabA humanized monoclonal antibody directed against human calcitonin-gene related peptide to prevent migraines.
AtogepantAn oral CGRP antagonist used for the preventative therapy of episodic migraine headaches.
RimegepantAn oral CGRP receptor antagonist used for the acute treatment of migraines with or without aura in adults.
UbrogepantAn oral CGRP antagonist used in the acute treatment of migraine with or without aura.
Drugs & Drug Targets
DrugTargetType
ErenumabCalcitonin gene-related peptide type 1 receptortarget
GalcanezumabCalcitonin gene-related peptide 1target
GalcanezumabCalcitonin gene-related peptide 2target
EptinezumabCalcitonin gene-related peptide 1target
EptinezumabCalcitonin gene-related peptide 2target
ZavegepantCalcitonin gene-related peptide type 1 receptortarget
ZavegepantCytochrome P450 3A4enzyme
ZavegepantCytochrome P450 2D6enzyme
ZavegepantSolute carrier organic anion transporter family member 1B3transporter
ZavegepantSodium/bile acid cotransportertransporter
ZavegepantP-glycoprotein 1transporter
ZavegepantMultidrug and toxin extrusion protein 1transporter
ZavegepantMultidrug and toxin extrusion protein 2transporter
FremanezumabCalcitonin gene-related peptide 1target
FremanezumabCalcitonin gene-related peptide 2target
AtogepantCalcitonin gene-related peptide type 1 receptortarget
AtogepantCytochrome P450 3A4enzyme
AtogepantSolute carrier organic anion transporter family member 1B1transporter
AtogepantSolute carrier organic anion transporter family member 1B3transporter
AtogepantSolute carrier family 22 member 6transporter
AtogepantATP-binding cassette sub-family G member 2transporter
AtogepantP-glycoprotein 1transporter
AtogepantSolute carrier family 22 member 1transporter
AtogepantMultidrug and toxin extrusion protein 1transporter
RimegepantCalcitonin gene-related peptide type 1 receptortarget
RimegepantP-glycoprotein 1transporter
RimegepantATP-binding cassette sub-family G member 2transporter
RimegepantSolute carrier organic anion transporter family member 1B1transporter
RimegepantSolute carrier family 22 member 8transporter
RimegepantSolute carrier organic anion transporter family member 1B3transporter
RimegepantSolute carrier family 22 member 2transporter
RimegepantMultidrug and toxin extrusion protein 1transporter
RimegepantCytochrome P450 3A4enzyme
RimegepantCytochrome P450 2C9enzyme
UbrogepantP-glycoprotein 1transporter
UbrogepantATP-binding cassette sub-family G member 2transporter
UbrogepantCytochrome P450 3A4enzyme
UbrogepantCytochrome P450 2C8enzyme
UbrogepantCytochrome P450 2C9enzyme
UbrogepantCytochrome P450 2D6enzyme
UbrogepantCytochrome P450 2C19enzyme
UbrogepantAmine oxidase [flavin-containing] Aenzyme
UbrogepantUDP-glucuronosyltransferase 1-1enzyme
UbrogepantSolute carrier organic anion transporter family member 1B1transporter
UbrogepantSolute carrier organic anion transporter family member 1B3transporter
UbrogepantSolute carrier family 22 member 6transporter
UbrogepantSolute carrier family 22 member 2transporter
UbrogepantCalcitonin gene-related peptide type 1 receptortarget