Isocitrate dehydrogenase-1 (IDH1) inhibitors

Name
Isocitrate dehydrogenase-1 (IDH1) inhibitors
Accession Number
DBCAT005660
Description

Not Available

Drugs
DrugDrug Description
IvosidenibAn isocitrate dehydrogenase-1 inhibitor used to treat acute myeloid leukemia and cholangiocarcinoma in adults with a susceptible IDH1 mutation.
OlutasidenibAn isocitrate dehydrogenase-1 (IDH1) inhibitor indicated for the treatment of patients with relapsed or refractory acute myeloid leukemia with a susceptible IDH1 mutation as detected by an FDA-approved test.
VorasidenibA isocitrate dehydrogenase type 1 (IDH1) and 2 (IDH2) inhibitor used to treat Grade 2 astrocytoma or oligodendroglioma with a susceptible IDH1 or IDH2 mutation.
Drugs & Drug Targets
DrugTargetType
IvosidenibIsocitrate dehydrogenase [NADP] cytoplasmictarget
IvosidenibCytochrome P450 3A4enzyme
IvosidenibCytochrome P450 2B6enzyme
IvosidenibCytochrome P450 2C9enzyme
IvosidenibCytochrome P450 2C8enzyme
IvosidenibOrganic anion transporter 3transporter
IvosidenibATP-dependent translocase ABCB1transporter
OlutasidenibIsocitrate dehydrogenase [NADP] cytoplasmictarget
OlutasidenibCytochrome P450 3A4enzyme
OlutasidenibCytochrome P450 2C8enzyme
OlutasidenibCytochrome P450 2C9enzyme
OlutasidenibCytochrome P450 1A2enzyme
OlutasidenibCytochrome P450 2C19enzyme
OlutasidenibATP-dependent translocase ABCB1transporter
OlutasidenibBroad substrate specificity ATP-binding cassette transporter ABCG2transporter
OlutasidenibSolute carrier organic anion transporter family member 1B1transporter
OlutasidenibSolute carrier organic anion transporter family member 1B3transporter
OlutasidenibOrganic anion transporter 3transporter
OlutasidenibSolute carrier family 22 member 2transporter
OlutasidenibMultidrug and toxin extrusion protein 1transporter
OlutasidenibMultidrug and toxin extrusion protein 2transporter
OlutasidenibCytochrome P450 2B6enzyme
VorasidenibCytochrome P450 1A2enzyme
VorasidenibCytochrome P450 2B6enzyme
VorasidenibCytochrome P450 2C8enzyme
VorasidenibCytochrome P450 2C9enzyme
VorasidenibCytochrome P450 2C19enzyme
VorasidenibCytochrome P450 2D6enzyme
VorasidenibCytochrome P450 3A4enzyme
VorasidenibUDP-glucuronosyltransferase 1A4enzyme
VorasidenibBroad substrate specificity ATP-binding cassette transporter ABCG2transporter
VorasidenibIsocitrate dehydrogenase [NADP] cytoplasmictarget
VorasidenibIsocitrate dehydrogenase [NADP], mitochondrialtarget
VorasidenibIsocitrate dehydrogenase [NAD] subunit alpha, mitochondrialtarget
VorasidenibIsocitrate dehydrogenase [NAD] subunit beta, mitochondrialtarget
VorasidenibIsocitrate dehydrogenase [NAD] subunit gamma, mitochondrialtarget
VorasidenibHuman Isocitrate Dehydrogenasestarget