- Enzyme Inhibitors
- Accession Number
Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.
Drug Drug Description Lepirudin A protein-based direct thrombin inhibitor used to reverse and prevent thrombus formation in heparin-induced thrombocytopenia. Bivalirudin A direct thrombin inhibitor used to treat heparin-induced thrombocytopenia and to prevent thrombosis during percutaneous coronary intervention. Alpha-1-proteinase inhibitor A purified form of human alpha-1 proteinase inhibitor used to treat emphysema patients with associated alpha-1 proteinase inhibitor deficiency. Cyclosporine A steroid-sparing immunosuppressant used in organ and bone marrow transplants as well as inflammatory conditions such as ulcerative colitis, rheumatoid arthritis, and atopic dermatitis. Pravastatin An HMG-CoA reductase inhibitor used to lower lipid levels and to reduce the risk of cardiovascular events, including myocardial infarction and stroke. Fluvoxamine A selective serotonin-reuptake inhibitor used to treat obsessive-compulsive disorder. Ramipril An ACE inhibitor used for the management of hypertension and the reduction of cardiovascular mortality following myocardial infarction in hemodynamically stable patients with clinical signs of congestive heart failure. Masoprocol Used for the treatment of actinic keratoses (precancerous skin growths that can become malignant if left untreated). Carbidopa A dopa decarboxylase inhibitor used in combination with levodopa for the symptomatic treatment of idiopathic Parkinson disease and other conditions associated with parkinsonian symptoms. Fluconazole A triazole antifungal used to treat various fungal infections including candidiasis. Erythromycin A macrolide antibiotic used to treat and prevent a variety of bacterial infections. Caffeine A stimulant present in tea, coffee, cola beverages, analgesic drugs, and agents used to increase alertness. It is also used in to prevent and treat pulmonary complications of premature birth. Sildenafil A phosphodiesterase inhibitor used for the treatment of erectile dysfunction. Pyrimethamine An antiparasitic drug used in the prevention and treatment of toxoplasmosis and malaria. Ticlopidine A platelet aggregation inhibitor used in the prevention of conditions associated with thrombi, such as stroke and transient ischemic attacks (TIA). Remikiren For the treatment of hypertension and heart failure Pantoprazole A proton pump inhibitor used to treat erosive esophagitis, gastric acid hypersecretion, and to promote healing of tissue damage caused by gastric acid. Moxifloxacin A fluoroquinolone antibiotic used to treat various bacterial infections. Nelfinavir A viral protease inhibitor used in the treatment of HIV infection. Indinavir A protease inhibitor used to treat HIV infection. Lovastatin An HMG-CoA reductase inhibitor used to lower LDL cholesterol and reduce the risk of cardiovascular disease and associated conditions, including myocardial infarction and stroke. Milrinone A PDE-III inhibitor with inotropic, lusitropic, and vasodilatory properties used for the short-term treatment of acute decompensated heart failure. Nevirapine A non-nucleoside reverse transcriptase inhibitor used as part of a management regimen for HIV-1 virus infection. Idoxuridine A pyrimidine analog antiviral used for the treatment of viral eye infections, including herpes simplex keratitis. Dapsone A sulfone drug used to treat acne vulgaris, Hansen's disease, and dermatitis herpetiformis. Clotrimazole A topical broad-spectrum antifungal agent used for the treatment of a wide variety of dermatophyte infections and candidiasis. Dicoumarol For decreasing blood clotting. Often used along with heparin for treatment of deep vein thrombosis. Theophylline A xanthine used to manage the symptoms of asthma, COPD, and other lung conditions caused by reversible airflow obstruction. Argatroban A synthetic direct thrombin inhibitor used for the prevention and treatment of thrombosis related to heparin use. Acarbose An alpha-glucosidase inhibitor used in adjunctly with diet and exercise for the management of glycemic control in patients with type 2 diabetes mellitus. Raltitrexed A folate analog thymidylate synthase inhibitor used in the treatment of advanced colorectal cancer. Mitomycin An antimetabolite used as an adjunct to ab externo (outside approach) eye surgeries for the treatment of glaucoma and used as a chemotherapeutic agent for various malignancies. Ethoxzolamide For use in the treatment of duodenal ulcers, as a diuretic, and in the treatment of glaucoma, and may also be useful in the treatment of seizures associated with epilepsy. Valproic acid An anticonvulsant used to control complex partial seizures and both simple and complex absence seizures. Capreomycin An aminoglycoside antibiotic used as an adjunct drug in tuberculosis. Gefitinib A tyrosine kinase inhibitor used as first-line therapy to treat non-small cell lung carcinoma (NSCLC) that meets certain genetic mutation criteria. Tolcapone A catechol-O-methyltransferase (COMT) inhibitor used as adjunct therapy in the symptomatic management of idiopathic Parkinson's disease. Indomethacin A nonsteroidal anti-inflammatory (NSAID) used for symptomatic management of chronic musculoskeletal pain conditions and to induce closure of a hemodynamically significant patent ductus arteriosus in premature infants. Pimecrolimus A topical calcineurin inhibitor used in the treatment of mild-moderate atopic dermatitis who are not candidates for other types of therapy due to previous lack of response or other reasons. Omeprazole A proton pump inhibitor used to treat GERD associated conditions such as heartburn and gastric acid hypersecretion, and to promote healing of tissue damage and ulcers caused by gastric acid and H. pylori infection. Nitisinone A hydroxyphenylpyruvate dioxygenase inhibitor used as an adjunct to dietary restrictions for the treatment of hereditary tyrosinemia type 1 (HT-1), which causes intolerance to tyrosine containing foods. Aminoglutethimide An adrenocortical steroid synthesis inhibitor used in the treatment of Cushing's syndrome. Grepafloxacin A fluoroquinolone antibiotic used to treat various gram positive and gram negative bacterial infections. Dexrazoxane A cytoprotective drug used to prevent and improve cardiomyopathy associated with doxorubicin treatment for metastatic breast cancer. Tacrine An anticholinesterase drug used for the management of Alzheimer's disease symptoms. Valrubicin An anthracycline used intravesically in the treatment of BCG-resistant bladder carcinoma. Sorafenib A kinase inhibitor used in the treatment of unresectable liver carcinoma and advanced renal carcinoma. Mupirocin An antibacterial ointment used to treat impetigo and secondary skin infections caused by Staphylococcus aureus and Streptococcus pyogenes. Miglustat A glucosylceramide synthase inhibitor used for the management of mild to moderate type I Gaucher disease for patients who are not candidates for whole enzyme replacement. Allopurinol A xanthine oxidase inhibitor used to reduce urinary and serum uric acid concentrations in patients with gout, recurrent calcium oxalate calculi, and various malignancies. Cerivastatin A statin (or HMG CoA reductase inhibitor) used with dietary changes to decrease lipid levels and reduce the risk of cardiovascular events. Trimethoprim An antifolate antibiotic often used in combination with sulfamethoxazole to treat a number of infections, including those of the urinary tract, respiratory tract, and gastrointestinal tract. Gemcitabine A nucleoside metabolic inhibitor used as adjunct therapy in the treatment of certain types of ovarian cancer, non-small cell lung carcinoma, metastatic breast cancer, and as a single agent for pancreatic cancer. Teniposide A cytotoxic drug used as an adjunct for chemotherapy induction in the treatment of refractory childhood acute lymphoblastic leukemia. Epirubicin An anthracycline topoisomerase II inhibitor used as an adjuvant to treating axillary node metastases in patients who have undergone surgical resection of primary breast cancer. Chloramphenicol A broad spectrum antibiotic that is effective against a variety of susceptible and serious bacterial infections but is not frequently used because of its high risk of bone marrow toxicity. Nabumetone An NSAID used to treat osteoarthritis and rheumatoid arthritis. Ketorolac An NSAID used to treat moderate to severe pain, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, menstrual disorders, and headaches. Enoxacin For the treatment of adults (≥18 years of age) with the following infections caused by susceptible strains of the designated microorganisms: (1) uncomplicated urethral or cervical gonorrhea due to Neisseria... Tenoxicam An anti inflammatory analgesic used to treat mild to moderate pain as well as the signs and symptoms of rheumatoid arthritis and osteoarthritis. Fluoxetine A selective serotonin reuptake inhibitor used to treat major depressive disorder, bulimia, OCD, premenstrual dysphoric disorder, panic disorder, and bipolar I. Rimantadine An RNA synthesis inhibitor used to prevent influenza A infection. Celecoxib An NSAID used to treat osteoarthritis, rheumatoid arthritis, acute pain, menstrual symptoms, and to reduce polyps is familial adenomatous polyposis. Pefloxacin An antibiotic used to treat a variety of bacterial infections. Miglitol An oral alpha-glucosidase inhibitor used to improve glycemic control by delaying the digestion of carbohydrates. Fosinopril An ACE inhibitor used to treat mild to moderate hypertension, congestive heart failure, and to slow the progression of renal disease in hypertensive diabetics. Entacapone A selective reversible catechol-O-methyltransferase inhibitor for the treatment of Parkinson's disease. Zidovudine A dideoxynucleoside used in the treatment of HIV infection. Tolmetin An NSAID used to treat acute flares of various painful conditions and used for the long term management of osteoarthritis, rheumatoid arthritis, and juvenile arthritis. Cimetidine A histamine H2 receptor antagonist used to manage GERD, peptic ulcer disease, and indigestion. Ritonavir An HIV protease inhibitor used in combination with other antivirals in the treatment of HIV infection. Acetyldigitoxin Used for fast digitalization in congestive heart failure. Trandolapril A prodrug of an ACE inhibitor used to treat hypertension, congestive heart failure, and to improve survival following a myocardial infarction. Foscarnet An antiviral used to treat CMV, HIV, and HSV infections. Erlotinib An EGFR tyrosine kinase inhibitor used to treat certain small cell lung cancers or advanced metastatic pancreatic cancers. Rofecoxib A COX-2 inhibitor NSAID used to treat osteoarthritis, rheumatoid arthritis, acute pain, primary dysmenorrhea, and migraine attacks. Ciprofloxacin A second generation fluoroquinolone used to treat various susceptible bacterial infections. Benazepril An ACE inhibitor prodrug used to treat hypertension. Pyridostigmine A cholinesterase inhibitor used for symptomatic treatment of myasthenia gravis and congenital myasthenic syndromes and to reverse neuromuscular blockade by nondepolarizing muscle relaxants. Acetohydroxamic acid A synthetic urea derivative used to treat urea splitting bacterial infections of the urinary tract. Pentostatin An adenosine deaminase inhibitor used to treat hairy cell leukemia. Piroxicam An NSAID used to treat the symptoms of osteoarthritis and rheumatoid arthritis. Zanamivir A neuraminidase inhibitor used to treat influenza A and B. Methotrexate An antineoplastic agent used the treatment of a wide variety of cancers as well as severe psoriasis, severe rheumatoid arthritis, and juvenile rheumatoid arthritis. Fenoprofen An anti-inflammatory analgesic used to treat mild to moderate pain in addition to the signs and symptoms of rheumatoid arthritis and osteoarthritis. Valdecoxib A COX-2 inhibitor used to treat osteoarthritis and dysmenorrhoea. Voriconazole A triazole compound used to treat fungal infections. Enalapril A prodrug of an ACE inhibitor used to treat hypertension and congestive heart failure. Diclofenac An NSAID used to treat the signs and symptoms of osteoarthritis and rheumatoid arthritis. Linezolid An oxazolidinone antibiotic used to treat infections by susceptible strains of aerobic Gram-positive bacteria. Sulindac An NSAID used to treat osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute subacromial bursitis or supraspinatus tendinitis, and acute gouty arthritis. Furazolidone A drug for the treatment of infectious diarrhea. Candoxatril Candoxatril is the orally-active prodrug of candoxatrilat (UK-73967), a potent neutral endopeptidase (NEP) inhibitor. Imatinib A tyrosine kinase inhibitor used to treat a number of leukemias, myelodysplastic/myeloproliferative disease, systemic mastocytosis, hypereosinophilic syndrome, dermatofibrosarcoma protuberans, and gastrointestinal stromal tumors. Triamcinolone A glucocorticoid used to treat a wide variety of inflammatory conditions of organ systems and tissues. Efavirenz A non-nucleoside reverse transcriptase inhibitor used to treat HIV infection or prevent the spread of HIV. Simvastatin An HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular events including myocardial infarction and stroke. Pemetrexed A folate analog used to treat mesothelioma and non-small cell lung cancer. Stavudine A dideoxynucleoside used in the treatment of HIV infection. Dyphylline A theophylline derivative used to treat asthma, bronchospasm, and COPD. Galantamine A cholinesterase inhibitor used to manage mild to moderate dementia associated with Alzheimer's Disease. Isoflurophate For use in the eye to treat certain types of glaucoma and other eye conditions, such as accommodative esotropia. Trovafloxacin An antibiotic used to treat gonorrhea and chlamydia. Moexipril An angiotensin converting enzyme inhibitor prodrug used to treat hypertension. Daunorubicin An anthracycline aminoglycoside used to induce remission of nonlymphocytic leukemia and acute lymphocytic leukemia. Amprenavir A protease inhibitor used to treat HIV infection. Methazolamide A carbonic anhydrase inhibitor used to treat open angle glaucoma and acute angle closure glaucoma. Delavirdine A non-nucleoside reverse transcriptase inhibitor used to treat HIV infection. Lamivudine A reverse transcriptase inhibitor used to treat HIV and hepatitis B infections. Diethylcarbamazine An anthelmintic used to treat filarial infections like Wuchereria bancrofti and Loa loa. Flurbiprofen An NSAID used to treat the signs and symptoms of osteoarthritis and rheumatoid arthritis. Paroxetine A selective serotonin reuptake inhibitor used to treat major depressive disorder, panic disorder, OCD, social phobia, generalized anxiety disorder, the vasomotor symptoms of menopause, and premenstrual dysphoric disorder. Adefovir dipivoxil A nucleotide analog used to treat chronic hepatitis B. Lisinopril An ACE inhibitor used to treat hypertension, heart failure, and acute myocardial infarction. Esomeprazole A proton pump inhibitor used to treat GERD, reduce the risk of NSAID associated gastric ulcers, eradicate H. pylori, and to treat conditions causing gastric acid hypersecretion. Zileuton A leukotriene synthesis inhibitor used in the prophylaxis and treatment of chronic asthma. Etodolac An NSAID used to treat osteoarthritis and rheumatoid arthritis, as well as acute pain. Tranylcypromine A monoamine oxidase inhibitor used to treat major depressive disorder. Tetracycline An antibiotic used to treat a wide variety of susceptible infections. Irinotecan An antineoplastic enzyme inhibitor used to treat metastatic carcinoma of the colon or rectum. Metyrosine A tyrosine 3-monooxygenase inhibitor used to treat excessive sympathetic stimulation in pheochromocytoma. Clavulanic acid A beta lactamase inhibitor used to enhance the effectiveness of beta lactam antibiotics. Malathion A parasympathomimetic organophosphate used to treat head lice. Etoposide A podophyllotoxin derivative used to treat testicular and small cell lung tumors. Nalidixic acid A quinolone antibiotic used to treat urinary tract infections. Phenelzine A monoamine oxidase inhibitor used to treat atypical, nonendogenous, or neurotic depression. Mefenamic acid An NSAID used to treat mild to moderate pain for no more than a week, and primary dysmenorrhea. Marimastat For the treatment of various cancers Naproxen An NSAID used to treat rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, polyarticular juvenile idiopathic arthritis, tendinitis, bursitis, acute gout, primary dysmenorrhea, and mild to moderate pain. Perindopril An ACE inhibitor prodrug used to treat hypertension, mild to moderate congestive heart failure, and to reduce cardiovascular risk in patients with hypertension or post-myocardial infarction. Gentamicin An aminoglycoside used to treat a wide variety of aerobic infections in the body. Pentoxifylline A methylxanthine derivative used to treat intermittent claudication caused by chronic occlusive arterial disease of the limbs. Acetazolamide A carbonic anhydrase inhibitor used to treat edema from heart failure or medications, certain types of epilepsy, and glaucoma. Tadalafil A phosphodiesterase 5 inhibitor used to treat erectile dysfunction, benign prostatic hyperplasia, and pulmonary arterial hypertension. Disulfiram A carbamate derivative used to treat alcohol addiction. Cinoxacin For the treatment of initial and recurrent urinary tract infections in adults caused by the following susceptible microorganisms: Escherichia coli, Proteus mirabilis, Proteus vulgaris, Klebsiella species (including K. pneumoniae), and... Donepezil An acetylcholinesterase inhibitor used to treat the behavioral and cognitive effects of Alzheimer's Disease and other types of dementia. Terbinafine An allylamine antifungal used to treat dermatophyte infections of toenails and fingernails as well as other fungal skin infections. Diflunisal An NSAID used to treat mild to moderate pain, inflammation, osteoarthritis, and rheumatoid arthritis. Vardenafil A phosphodiesterase 5 inhibitor used to treat erectile dysfunction. Tacrolimus A calcineurin inhibitor used to prevent organ transplant rejection and to treat moderate to severe atopic dermatitis. Dorzolamide A carbonic anhydrase inhibitor used to treat high intraocular pressure in ocular hypertension and open angle glaucoma. Suprofen An NSAID used to prevent pupil constriction in ocular surgery. Emtricitabine A nucleoside reverse transcriptase inhibitor used for the treatment and prophylaxis of HIV. Quinapril An ACE inhibitor prodrug used to treat hypertension, congestive heart failure, and slow rate of progression of renal disease. Omapatrilat For the treatment of hypertension. Didanosine A reverse transcriptase inhibitor used to treat HIV. Etacrynic acid A diuretic used to treat ascites and edema in congestive heart failure, liver cirrhosis, and renal disease. Quinidine A medication used to restore normal sinus rhythm, treat atrial fibrillation and flutter, and treat ventricular arrhythmias. Levosimendan A calcium sensitizer indicated to treat acutely decompensated severe chronic heart failure. Azacitidine A pyrimidine nucleoside analogue used to treat certain subtypes of myelodysplastic syndrome. Salicylic acid An acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. Meclofenamic acid An NSAID used to treat mild to moderate pain, primary dysmenorrhea, heavy menstrual blood loss, rheumatoid arthritis, and osteoarthritis. Zalcitabine A dideoxynucleoside used to treat HIV. Demecarium For the topical treatment of chronic open-angle glaucoma. Netilmicin An aminoglycoside used to treat a wide variety of infections in the body. Dactinomycin An actinomycin used to treat a wide variety of cancers. Azelastine A histamine H1-receptor antagonist used intranasally to treat allergic and vasomotor rhinitis and in an ophthalmic solution to treat allergic conjunctivitis. Dipyridamole A phosphodiesterase inhibitor used to prevent postoperative thromboembolic events. Lomefloxacin A fluoroquinolone used to prevent and treat a wide variety of infections in the body. Physostigmine A cholinesterase inhibitor used to treat glaucoma and anticholinergic toxicity. Rivastigmine A cholinesterase inhibitor used to treat mild to moderate dementia in Alzheimer's and Parkinson's. Exemestane An aromatase inhibitor used to treat breast cancer in postmenopausal women after treatment with tamoxifen. Neomycin An aminoglycoside antibiotic agent used orally and topically to treat a wide variety of infections in the body. Doxorubicin A medication used to treat various cancers and Kaposi's Sarcoma. Hydroxyurea An antimetabolite used to treat sickle cell anemia crisis. Letrozole An aromatase inhibitor used to treat breast cancer in postmenopausal women. Tioconazole An imidazole antifungal used to treat vulvovaginal candidiasis. Ketoprofen An NSAID used to treat rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, dysmenorrhea, mild to moderate muscle pain, postoperative pain, and postpartum pain. Edrophonium A cholinesterase inhibitor used to diagnose and evaluate myasthenia gravis. Metyrapone A steroid 11-beta-monooxygenase inhibitor used to test hypothalamic-pituitary ACTH function. Mycophenolic acid An immunosuppressant used to prevent organ transplant rejections. Ketoconazole A broad spectrum antifungal used to treat seborrheic dermatitis and fungal skin infections. Topotecan An antineoplastic agent used to treat ovarian cancer, small cell lung cancer, or cervical cancer. Mercaptopurine An antineoplastic agent used to treat acute lymphocytic leukemia. Selegiline A monoamine oxidase inhibitor used to treat major depressive disorder and Parkinson's. Gatifloxacin A fourth generation fluoroquinolone used to treat a wide variety of infections in the body. Rifampicin An antibiotic used to treat several types of mycobacterial infections including Mycobacterium avium complex, leprosy, and in combination with other antibacterials to treat latent or active tuberculosis. Abacavir An antiviral nucleoside reverse transcriptase inhibitor used in combination with other antiretrovirals for the treatment of HIV. Ibuprofen An NSAID and non-selective COX inhibitor used to treat mild-moderate pain, fever, and inflammation. Novobiocin For the treatment of infections due to staphylococci and other susceptible organisms Echothiophate An acetylcholinesterase inhibitor used in ophthalmic preparations to increase the drainage of intraocular fluid; most commonly used for the treatment of glaucoma. Norfloxacin A broad-spectrum fluoroquinolone antibiotic with variable activity against gram-positive and gram-negative bacteria. Typically reserved for the treatment of UTIs due to accumulation in the urine. Atazanavir An antiviral protease inhibitor used in combination with other antiretrovirals for the treatment of HIV. Fludarabine A purine analog antimetabolite that inhibits DNA synthesis. Atorvastatin An HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke. Deslanoside For the treatment and management of Congestive cardiac insufficiency, arrhythmias and heart failure. Orlistat A reversible inhibitor of gastrointestinal lipases indicated for weight loss and weight maintenance. Ouabain For the treatment of atrial fibrillation and flutter and heart failure Leflunomide A pyrimidine synthesis inhibitor indicated to treat rheumatoid arthritis. Rosuvastatin An HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke. Quinacrine For the treatment of giardiasis and cutaneous leishmaniasis and the management of malignant effusions. Trilostane Used in the treatment of Cushing's syndrome. It is normally used in short-term treatment until permanent therapy is possible. Miconazole An azole antifungal with broad-spectrum activity used to treat fungal infections affecting the vagina, mouth and skin, including candidiasis. Papaverine An alkaloid used to treat many types of smooth muscle spasms such as "vascular spasms" associated with acute myocardial infarction and angina pectoris, as well as "visceral spasms". Atovaquone An antimicrobial indicated for the prevention and treatment of Pneumocystis jirovecii pneumonia (PCP) and for the prevention and treatment of Plasmodium falciparum malaria. Amiodarone A class III antiarrhythmic indicated for the treatment of recurrent hemodynamically unstable ventricular tachycardia and recurrent ventricular fibrillation. Ambenonium A cholinesterase inhibitor that targets both muscarinic and nicotinic receptors indicated for the treatment of myasthenia gravis. Dutasteride An antiandrogenic compound that is used for the treatment of symptomatic benign prostatic hyperplasia (BPH) in adult males by inhibiting 5-alpha reductase. Econazole A topical antifungal used to treat tinea pedis, tinea cruris, tinea corporis, cutaneous candidiasis and tinea versicolor. Rabeprazole A proton pump inhibitor used to help gastrointestinal ulcers heal, to treat symptoms of gastroesophageal reflux disease (GERD), to eradicate Helicobacter pylori, and to treat hypersecretory conditions such as Zollinger-Ellison Syndrome. Levofloxacin A fluoroquinolone antibiotic used to treat infections caused by susceptible bacteria of the upper respiratory tract, skin and skin structures, urinary tract, and prostate, as well as for post-exposure treatment of inhaled anthrax and the plague. Diclofenamide A carbonic anhydrase inhibitor used for the management of open-angle and secondary glaucoma, as well as acute angle-closure glaucoma in delayed pre-operative setting requiring a reduction in intraocular pressure. Desipramine A tricyclic antidepressant used in the treatment of depression. Gemifloxacin A quinolone antibacterial agent used for the treatment of acute bacterial exacerbation of chronic bronchitis and mild to moderate community-acquired pneumonia caused by susceptible bacteria. Bupropion A norepinephrine and dopamine reuptake inhibitor used in the treatment of major depressive disorder (MDD), seasonal affective disorder (SAD), and as an aid to smoking cessation. Trimetrexate A folate antagonist used for the treatment of moderate-to-severe Pneumocystis carinii pneumonia (PCP) in immunocompromised patients as an alternative therapy in combination with leucovorin. Ofloxacin An antibacterial agent used for the treatment of bacterial infections in many parts of the body, including the respiratory tract, kidney, skin, soft tissue, and urinary tract. Cilostazol An antiplatelet agent and vasodilator used for the symptomatic relief of intermittent claudication. Itraconazole An antifungal agent used for the treatment of various fungal infections in immunocompromised and non-immunocompromised patients, such as pulmonary and extrapulmonary blastomycosis, histoplasmosis, and onychomycosis. Moclobemide A monoamine oxidase inhibitor used in the treatment of major depressive disorder and bipolar disorder. Kanamycin An aminoglycoside antibiotic agent used in the treatment of various infections caused by susceptible bacteria. Orphenadrine A muscarinic antagonist used as an adjunct for the symptomatic relief of musculoskeletal pain and discomfort. Idarubicin An anthracycline antineoplastic agent used to treat acute myeloid leukemia (AML) in adults. Clindamycin A lincosamide antibiotic used to treat serious infections caused by susceptible anaerobic, streptococcal, staphylococcal, and pneumococcal bacteria. Brinzolamide A carbonic anhydrase inhibitor used for the reduction of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma. Captopril An ACE inhibitor used for the management of essential or renovascular hypertension, congestive heart failure, left ventricular dysfunction following myocardial infarction, and nephropathy. Mitoxantrone A chemotherapeutic agent used for the treatment of secondary progressive, progressive relapsing, or worsening relapsing-remitting multiple sclerosis. Ridogrel Used as an adjunctive therapy to induce thrombolysis in patients suffering acute myocardial infarction. Sparfloxacin A fluoroquinolone antibiotic used to treat bacterial respiratory infections and sinusitis. Clarithromycin A macrolide antibiotic used for the treatment of a wide variety of bacterial infections such as acute otitis, pharyngitis, tonsillitis, respiratory tract infections, uncomplicated skin infections, and helicobacter pylori infection. Finasteride An antiandrogenic compound that is used for the treatment of symptomatic benign prostatic hyperplasia (BPH) and male pattern hair loss in adult males by inhibiting Type II 5-alpha reductase. Anastrozole A competitive, selective, non-steroidal aromatase inhibitor used as adjuvant therapy for the treatment of hormone receptor-positive breast cancer in postmenopausal women. Aminophylline A bronchodilator consisting of theophylline that is used for the treatment of bronchospasm due to asthma, emphysema and chronic bronchitis. Saquinavir An HIV protease inhibitor used in combination with other antiretroviral agents for the treatment of HIV-1 with advanced immunodeficiency. Gemfibrozil A lipid regulator that is used in the reduction of serum triglyceride levels in high-risk patients with hyperlipidemia. Isocarboxazid A monoamine oxidase inhibitor used to treat enduring and debilitating symptoms of depression following inadequate clinical response to other antidepressant drugs. Dasatinib A tyrosine kinase inhibitor used for the treatment of lymphoblastic or chronic myeloid leukemia with resistance or intolerance to prior therapy. Lapatinib An antineoplastic agent and tyrosine kinase inhibitor used for the treatment of advanced or metastatic HER-negative breast cancer in patients who received prior chemotherapeutic treatments. Sitagliptin An oral dipeptidyl peptidase-4 (DPP-4) inhibitor used for the management of type 2 diabetes mellitus. Decitabine A chemotherapeutic pyrimidine nucleoside analogue used for the treatment of myelodysplastic syndromes (MDS) by inducing DNA hypomethylation and corresponding alterations in gene expression. Posaconazole A triazole antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients. Darunavir A HIV protease inhibitor used in the treatment of human immunodeficiency virus (HIV) infection in patients with history of prior antiretroviral therapies. Telbivudine A thymidine nucleoside analog used for the treatment of chronic hepatitis B with clinical evidence of viral replication or persistent elevations in serum aminotransferases (ALT or AST). Lumiracoxib For the acute and chronic treatment of the signs and symptoms of osteoarthritis of the knee in adults. Fosamprenavir An antiretroviral agent used for the treatment and postexposure prophylaxis of human immunodeficiency virus (HIV-1) infection. Cilazapril An ACE inhibitor used for the management of hypertension and heart failure. Spirapril Spirapril is an ACE inhibitor class drug used to treat hypertension. Rasagiline An irreversible inhibitor of monoamine oxidase used for the symptomatic management of idiopathic Parkinson's disease as initial monotherapy and as adjunct therapy to levodopa. Mibefradil For the treatment of angina and high blood pressure. Digitoxin A cardiac glycoside used in the treatment and management of congestive cardiac insufficiency, arrhythmias and heart failure. Magnesium salicylate An NSAID analgesic used in the symptomatic relief of mild to moderate muscular pain. Neostigmine A cholinesterase inhibitor used in the symptomatic treatment of myasthenia gravis by improving muscle tone. Temafloxacin For the treatment of lower respiratory tract infections, genital and urinary infections like prostatitis, and skin infections. Amrinone A positive inotropic agent and phosphodiesterase inhibitor used in the management of treatment of congestive heart failure. Cilastatin A renal dehydropeptidase inhibitor used to prevent degradation of imipenem. Both medications are used together to treat a variety of infections. Lopinavir An HIV-1 protease inhibitor used in combination with ritonavir to treat human immunodeficiency virus (HIV) infection. Tazobactam A beta lactamase inhibitor administered with antibiotics such as piperacillin and ceftolozane to prevent their degradation, resulting in increased efficacy. Hydroxychloroquine An antimalarial medication used to treat uncomplicated cases of malaria and for chemoprophylaxis in specific regions. Also a disease modifying anti-rheumatic drug (DMARD) indicated for treatment of rheumatoid arthritis and lupus erythematosus. Pargyline For the treatment of moderate to severe hypertension. Lincomycin An antibiotic indicated only for the treatment of serious infections and is typically reserved for use in cases of penicillin allergy or where penicillin is inappropriate. Etoricoxib A selective COX-2 inhibitor used to relieve moderate post-surgical dental pain as a short-term treatment and inflammatory and painful symptoms of various forms of arthritis. Genistein Currently Genistein is being studied in clinical trials as a treatment for prostate cancer. Chymostatin Not Available N,N-dimethylarginine Asymmetric dimethylarginine (ADMA) is a naturally occurring chemical found in blood plasma. It is a metabolic by-product of continual protein modification processes in the cytoplasm of all human cells which... Piclamilast Piclamilast (RP-73,401), is a selective PDE4 inhibitor comparable to other PDE4 inhibitors for its anti-inflammatory effects. It has been investigated for its applications to the treatment of conditions such as... Castanospermine Not Available 7-Hydroxystaurosporine Not Available Rolipram A phosphodiesterase inhibitor with antidepressant properties. Staurosporine An indolocarbazole that is a potent protein kinase C inhibitor which enhances cAMP-mediated responses in human neuroblastoma cells. (Biochem Biophys Res Commun 1995;214(3):1114-20) Alrestatin Not Available Gabaculine Not Available Aminooxyacetic acid A compound that inhibits aminobutyrate aminotransferase activity in vivo, thereby raising the level of gamma-aminobutyric acid in tissues. [PubChem] 3,5-Dinitrocatechol Not Available Daidzin Not Available Olomoucine Not Available K-252a Not Available 7-Nitroindazole Not Available Ilomastat Not Available 5'-S-methyl-5'-thioadenosine Not Available 1,10-Phenanthroline Not Available Tolrestat For the pharmacological control of certain diabetic complications. Geldanamycin Not Available Trehalose-6-Phosphate Not Available Vorinostat A histone deacetylase (HDAC) inhibitor used for the treatment of cutaneous manifestations in patients with progressive, persistent, or recurrent cutaneous T- cell lymphoma (CTCL) following prior systemic therapies. Phosphoramidon Not Available 4-Hydroxyphenylglycine Not Available LY-294002 Specific inhibitor of phosphatidylinositol 3-kinase. Fusidic acid A topical antibacterial agent used to prevent and treat mild to moderate skin infections caused by susceptible bacteria. Resveratrol Being investigated for the treatment of Herpes labialis infections (cold sores). Kifunensine Not Available Pyrazole Not Available Phosphonoacetic Acid A simple organophosphorus compound that inhibits DNA polymerase, especially in viruses and is used as an antiviral agent. [PubChem] N-(3-Propylcarbamoyloxirane-2-Carbonyl)-Isoleucyl-Proline Not Available Calyculin A Not Available Dazoxiben Not Available 3-Methoxybenzamide Not Available Benzamidine A drug used to treat painful and inflammatory conditions of the oral cavity, such as infections and gingivitis. Duvoglustat An alpha-glucosidase inhibitor with antiviral action. Derivatives of deoxynojirimycin may have anti-HIV activity. Imidazole Not Available Enalkiren Not Available Ubenimex An adjuvant therapy used for acute and chronic myelonous leukemia, lung cancer and nasopharyngeal cancer. It is also used to treat hypercholesterolaemia. Sparfosic acid Sparfosic acid is a solid. This compound belongs to the n-acyl-alpha amino acids. These are compounds containing an alpha amino acid which bears an acyl group at the terminal nitrogen... Alvocidib Investigated for use/treatment in esophageal cancer, leukemia (lymphoid), lung cancer, liver cancer, and lymphoma (unspecified). 2-(4-Chlorophenyl)-5-Quinoxalinecarboxamide Not Available Eniluracil For the treatment of cancer in combination with 5-fluorouracil. Phencyclidine A hallucinogen formerly used as a veterinary anesthetic, and briefly as a general anesthetic for humans. Phencyclidine is similar to ketamine in structure and in many of its effects. Like... Picric acid Used as antiseptic, astringent, and stimulant for epitheliazation. Radicicol Not Available Palmitic Acid A fatty used as a food additive and emollient or surfactant in cosmetics. Cilomilast Investigated for use/treatment in chronic obstructive pulmonary disease (COPD). Batimastat Not Available S-Hexylglutathione Not Available Sparsomycin An antitumor antibiotic produced by Streptomyces sparsogenes. It inhibits protein synthesis in 70S and 80S ribosomal systems. [PubChem] Nitroarginine An inhibitor of nitric oxide synthetase which has been shown to prevent glutamate toxicity. Nitroarginine has been experimentally tested for its ability to prevent ammonia toxicity and ammonia-induced alterations in... Dipicolinic acid Not Available Oxfenicine Oxfenicine in an inhibitor of myocardial metabolism of nonesterified fatty acids (NEFA). Maleic acid Not Available D-4-hydroxyphenylglycine Not Available 3,4-Dichloroisocoumarin Not Available N-(6-Aminohexyl)-5-Chloro-1-Naphthalenesulfonamide Not Available 2,4-Dinitrophenol A toxic dye, chemically related to trinitrophenol (picric acid), used in biochemical studies of oxidative processes where it uncouples oxidative phosphorylation. It is also used as a metabolic stimulant. (Stedman,... Glyphosate Not Available Niflumic acid A cyclooxygenase-2 inhibitor used to alleviate inflammation, pain, and edema associated with acute and chronic inflammatory conditions, such as rheumatoid arthritis, osteoarthritis, post-operative inflammatory conditions, and physical trauma. Fleroxacin Fleroxacin is a broad-spectrum antimicrobial fluoroquinolone. 5-iodotubercidin Not Available Allosamidin Allosamidin exhibits extremely potent inhibitory activity against chitinases from a number of sources, particularly from Candida albicans, and can be utilized as potent antifungal agent. Metoprine Not Available Camptothecin Investigated for the treatment of cancer. Nimesulide A cyclooxygenase 2 inhibitor used to treat acute pain and primary dysmenorrhea. Lawsone Not Available Benoxaprofen The use of benoxaprofen, formerly marketed as Oraflex tablets, was associated with fatal cholestatic jaundice among other serious adverse reactions. The holder of the approved application voluntarily withdrew Oraflex tablets... Iproniazid For the treatment of depression (originally intended to treat tuberculosis). Nialamide Withdrawn from the Canadian, US, and UK markets in 1963 due to interactions with food products containing tyrosine. Cediranib For the treatment of liver cancer, advanced non-small cell lung cancer (NSCLC), advanced colorectal cancer (CRC) and other solid tumors. Huperzine A Investigated for use/treatment in alzheimer's disease. Halofuginone For the treatment of scleroderma, cancer, and restenosis. Vildagliptin A once-daily dipeptidyl peptidase 4 (DPP-4) inhibitor used in the management of type 2 diabetes mellitus. Voglibose An alpha-glucosidase inhibitor indicated in the management of postprandial blood glucose in patients with type II diabetes. Vatalanib Used in combination with first- and second-line chemotherapy for the treatment of metastatic colorectal cancer and non-small cell lung cancer (NSCLC). Enoximone A selective phosphodiesterase inhibitor indicated in the short term treatment of congestive heart failure. Ximelagatran For the treatment of acute deep vein thrombosis. Stannsoporfin Investigated for use/treatment in liver disease, metabolic disease, and pediatric indications. Permethrin An insecticide used to prevent infestation with Sarcoptes scabiei (scabies). Ranpirnase For the treatment of various forms of cancer. Belinostat A histone deacetylase (HDAC) inhibitor used for the treatment of patients with relapsed or refractory peripheral T-cell lymphoma (PTCL). Amonafide Investigated for use/treatment in breast cancer, ovarian cancer, and prostate cancer. Tetrathiomolybdate Investigated for use/treatment in liver disease and pulmonary fibrosis. Prinomastat Investigated for use/treatment in brain cancer, lung cancer, and prostate cancer. Elafin Investigated for use/treatment in inflammatory disorders (unspecified). PTC299 Investigated for use/treatment in cancer/tumors (unspecified) and solid tumors. Oxypurinol Intended for the treatment of congestive heart failure and hyperuricemia. Ecabet For the treatment of reflux oesophagitis and peptic ulcer disease. Ibudilast For the treatment of multiple sclerosis, asthma, and cerebrovascular disease. Dexlansoprazole A proton pump inhibitor used to help gastrointestinal ulcers heal, to treat symptoms of gastroesophageal reflux disease (GERD), to eradicate Helicobacter pylori, and to treat hypersecretory conditions such as Zollinger-Ellison Syndrome. Varespladib methyl Investigated for use/treatment in atherosclerosis and coronary artery disease. Abiraterone An antiandrogen used in the treatment of prostate cancer. Rubitecan Investigated for use/treatment in pancreatic cancer, leukemia (unspecified), melanoma, ovarian cancer, and cancer/tumors (unspecified). Garenoxacin Investigated for use/treatment in bacterial infection. Pixantrone An antineoplastic agent use to treat patients with relapsed or refractory aggressive Non-Hodgkin B-cell Lymphomas (NHL). Seliciclib Investigated for use/treatment in breast cancer, lung cancer, lymphoma (unspecified), multiple myeloma, leukemia (lymphoid), and cancer/tumors (unspecified). Alogliptin A dipeptidyl peptidase-4 (DPP-4) inhibitor used to treat hyperglycemia in patients with type 2 diabetes mellitus. Rivaroxaban A factor Xa inhibitor used to treat deep vein thrombosis (DVT) and pulmonary embolism (PE). May also be used as thrombosis prophylaxis in specific situations. Eflornithine A medication used topically to reduce unwanted facial hair growth in women. The postulated mechanism of action is through irreversible inhibition of ornithine decarboxylase (ODC) in the skin. Exisulind Investigated for use/treatment in adenomatous polyposis coli, lung cancer, prostate cancer, colon polyps, Barrett's esophagus disease, and pediatric indications. Udenafil A PDE5 inhibitor used to treat erectile dysfunction. Simeprevir A direct-acting antiviral agent that inhibits HCV NS3/4A protease to treat chronic hepatitis C virus (HCV) infection in adults with HCV genotype 1 or 4. Darapladib Investigated for use/treatment in atherosclerosis. Saxagliptin An DPP-4 inhibitor used for the management of type 2 diabetes mellitus. Iclaprim Investigated for use/treatment in bacterial infection, skin infections/disorders, obesity, liver disease, kidney disease, and pneumonia. Idraparinux Investigated for use/treatment in thrombosis, venous thromboembolism, strokes, heart disease, and atrial fibrillation. Etravirine A non-nucleoside reverse transcriptase inhibitor (NNRTI) used in the treatment of HIV-1 infections in combination with other antiretroviral agents. Tezacitabine Investigated for use/treatment in colorectal cancer, lung cancer, leukemia (unspecified), and gastric cancer. Semaxanib Investigated for use/treatment in colorectal cancer and lung cancer. MLN576 Investigated for use/treatment in solid tumors. Midostaurin An antineoplastic agent used to treat high-risk acute myeloid leukemia (AML) with specific mutations, aggressive systemic mastocytosis (ASM), systemic mastocytosis with associated hematologic neoplasm (SM-AHN), or mast cell leukemia (MCL). Panobinostat A non-selective histone deacetylase inhibitor used to treat multiple myeloma in combination with other antineoplastic agents. Apixaban An anticoagulant used for the prophylaxis of stroke and systemic embolism in nonvalvular atrial fibrillation, and deep vein thrombosis(DVT) leading to pulmonary embolism(PE), including in patients after a hip or knee replacement surgery. Peramivir An intravenous antiviral agent used to treat acute uncomplicated influenza in patients aged 2 years and older who are shown to be symptomatic for no more than two days. Axitinib An oral VEGFR and kinase inhibitor used for the treatment of advanced renal cell carcinoma after failure of one prior systemic therapy. N-chlorotaurine Investigated for use/treatment in eye disorders/infections. Otamixaban Investigated for use/treatment in thrombosis. Aprotinin A serine protease inhibitor used to reduce the risk for perioperative blood loss and the need for blood transfusion in high-risk patients during cardiopulmonary bypass for coronary artery bypass graft surgery. Mevastatin Not used therapeutically due to its many side effects. Dabigatran etexilate An anticoagulant used for the prevention of venous thromboembolic events or stroke in patients with recent elective hip or knee replacement surgery and atrial fibrillation. Iobenguane A radiopharmaceutical agent used for the diagnosis of primary and metastatic pheochromocytoma or neuroblastoma. beta-Naphthoflavone β-Naphthoflavone, also known as 5,6-benzoflavone, is a potent agonist of the aryl hydrocarbon receptor and induces cytochromes P450 (CYPs) and uridine 5'-diphospho-glucuronosyltransferases (UGTs). It may be a chemopreventive agent. Bafilomycin A1 The bafilomycins refer to a category of toxic macrolide antibiotics that are derivatives of Streptomyces griseus. These compounds all appear in the same fermentation and have similar biological activity. Bafilomycins... Besifloxacin A fluoroquinolone antibiotic agent used for the treatment of bacterial conjunctivitis. Plicamycin For the treatment of testicular cancer, as well as hypercalcemia and hypercalciuria associated with a variety of advanced forms of cancer. Raltegravir An antiretroviral agent used for the treatment of HIV infections in conjunction with other antiretrovirals. Viomycin Viomycin is an essential component in the drug cocktail currently used to fight infections of Mycobacterium tuberculosis. Veliparib Not Available 4-(2-Aminoethyl)Benzenesulfonyl Fluoride Not Available Brefeldin A A metabolite from Penicillium brefeldianum that exhibits a wide range of antibiotic activity. Anisomycin Anisomycin (sometimes known as flagecidin), is an antibiotic retrieved from the bacteria Streptomyces griseolus. This drug acts to inhibit bacterial protein and DNA synthesis. Z-Val-Ala-Asp fluoromethyl ketone Non-methylated, competitive, and irreversible inhibitor of caspase 1, as well as other caspases,1 which can be used directly with purified enzymes. It does not require an esterase to hydrolyze the... 3-isobutyl-1-methyl-7H-xanthine Not Available 5-(2-methylpiperazine-1-sulfonyl)isoquinoline Not Available Puromycin Puromycin is an antibiotic that prevents bacterial protein translation. It is utilized as a selective agent in laboratory cell cultures. Puromycin is toxic to both prokaryotic and eukaryotic cells, resulting... Parecoxib A selective COX-2 inhibitor and NSAID used for the short-term management of perioperative pain. 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline Potent reversible inhibitor of phenylethanolamine N-methyltransferase. Thiorphan A potent inhibitor of membrane metalloendopeptidase (enkephalinase). Thiorphan potentiates morphine-induced analgesia and attenuates naloxone-precipitated withdrawal symptoms. Temocapril Temocapril is an ACE inhibitor primarily indicated in the treatment of hypertension and congestive heart failure, diabetic nephropathy, and improvement of prognosis for coronary artery diseases (including acute myocardial infarction). Pitavastatin An HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke. Rilpivirine A non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with other antiretrovirals to specifically treat human immunodeficiency virus type 1 (HIV-1). Crizotinib A receptor tyrosine kinase inhibitor used to treat metastatic non-small cell lung cancer (NSCLC) where the tumors have been confirmed to be anaplastic lymphoma kinase (ALK), or ROS1-positive. Aminopterin Prior to its withdrawal, aminopterin was initially used in the treatment of childhood leukemia; specifically to induce remissions. Later, aminopterin was used off-label in the United States to treat psoriasis,... Linagliptin A dipeptidyl peptidase-4 (DPP-4) inhibitor used to manage hyperglycemia in patients with type 2 diabetes mellitus. Tofacitinib A Janus kinase (JAK) inhibitor used to treat rheumatoid and psoriatic arthritis, and ulcerative colitis. It is not recommended to be combined with biologic therapies or potent immunosuppressants like cyclosporine or azathioprine. Ponatinib A kinase inhibitor used to treat patients with various types of chronic myeloid leukemia (CML). Formestane For the treatment of estrogen-receptor positive breast cancer in post-menopausal women. Trametinib A kinase inhibitor used to treat patients with specific types of melanoma, non-small cell lung cancer, and thyroid cancer. Dabrafenib A kinase inhibitor used to treat patients with specific types of melanoma, non-small cell lung cancer, and thyroid cancer. Dolutegravir An antiviral agent used for the treatment of HIV-1 infections in combination with other antiretroviral agents. Indoprofen A drug that has analgesic and anti-inflammatory properties. Following reports of adverse reactions including reports of carcinogenicity in animal studies it was withdrawn from the market worldwide. Flumequine Flumequine is a synthetic chemotherapeutic antibiotic of the fluoroquinolone drug class used to treat bacterial infections. Fenbufen Fenbufen is a non-steroidal anti-inflammatory drug used primarily to treat inflammation in osteoarthritis, ankylosing spondylitis, and tendinitis. It can also be used to relieve backaches, sprains, and fractures. Fenbufen is... Eliglustat A glucosylceramide synthase used to treat type 1 Gaucher disease in patients who are CYP2D6 extensive, intermediate, or poor metabolizers, based on the FDA-approved test. Idelalisib An antineoplastic kinase inhibitor used to treat chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). Avibactam A non-β-lactam β-lactamase inhibitor used in combination with ceftazidime for the treatment of complicated intra-abdominal infections, complicated urinary tract infections, and hospital or ventilator-acquired pneumonia. Ceritinib An antineoplastic kinase inhibitor used to treat anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC) in patients with inadequate clinical response or intolerance to crizotinib. Cobicistat A CYP3A inhibitor used to increase the systemic exposure of atazanavir or darunavir in combination with other antiretroviral agents in the treatment of HIV-1 infection. Palbociclib An endocrine-based chemotherapeutic agent used in combination with other antineoplastic agents to treat HER2-negative and HR-positive advanced or metastatic breast cancer. Olaparib A chemotherapeutic agent used to treat recurrent or advanced ovarian cancer and metastatic breast cancer in patients with specific mutations and prior history of chemotherapy. Edoxaban A novel oral anticoagulant used for reducing the risk of stroke and systemic embolism (SE) in patients with nonvalvular atrial fibrillation (NVAF). Lenvatinib A receptor tyrosine kinase inhibitor used for the treatment of metastatic thyroid cancer, advanced renal cell carcinoma in combination with everolimus, and unresectable hepatocellular carcinoma. Nintedanib A triple angiokinase inhibitor indicated for the treatment of idiopathic pulmonary fibrosis, systemic sclerosis-associated interstitial lung disease, and in combination with docetaxel for non-small cell lung cancer. Chlortetracycline The first tetracycline antibiotic most commonly used for veterinary purposes. Methylene blue An oxidation-reduction agent used for the treatment of pediatric and adult patients with acquired methemoglobinemia. Pirlindole For the treatment of major depression. It is being studied in the treatment of fibromyalgia pain syndrome. One study determined that the effect of pirlindole on sensorimotor performance while driving... Toloxatone For the treatment of major depressive disorder. Doxofylline A methylxanthine derivative used in chronic obstructive pulmonary disease, asthma, and bronchospasms. Trapidil Used in the treatment of chronic stable angina . Sulbactam An beta-lactamase inhibitor antibiotic combined with other antibiotics to treat a variety of susceptible bacterial infections. Osimertinib A tyrosine kinase inhibitor used in the treatment of certain types of non-small cell lung carcinoma. Alatrofloxacin A fluoroquinolone antibiotic used to treat a variety of bacterial infections. Mersalyl Elevated blood pressure, edema [L1577, L1585]. Enalaprilat An antihypertensive agent used for the management of hypertension when oral therapy is not practical. Coumaphos This drug is a fat-soluble phosphorothioate agent that kills both insects and mites. It is non-volatile in nature and is well known by a variety of names as such a... Dichlorvos Dichlorvos or 2,2-dichlorovinyl dimethyl phosphate is a drug of the organophosphate class, frequently used as an insecticide for the control of indoor pests and for the protection of stored products... Fenthion Fenthion is an organothiophosphate drug used as an insecticide, avicide, and acaricide. Its mode of action is explained by cholinesterase enzyme inhibition, which is similar to other organophosphates. Fenthion is... Monensin Monensin is a polyether isolated from Streptomyces cinnamonensis that presents antibiotic properties. It is widely used in ruminant animal feeds. Pimobendan Not Annotated Rotenone Rotenone is an isoflavone compound that naturally occurs in the jicama vine plant as well as many Fabaceae plants. It has broad spectrum insecticide and pesticide activity and is also... Metrifonate Metrifonate or trichlorfon is an irreversible organophosphate acetylcholinesterase inhibitor. It is a prodrug which is activated non-enzymatically into 2,2-dichlorovinyl dimethyl phosphate. Virginiamycin Virginiamycin is a streptogramin antibiotic similar to pristinamycin and quinupristin/dalfopristin. It is a combination of pristinamycin IIA and virginiamycin S1. Virginiamycin is used in the fuel ethanol industry to prevent... Deslorelin Deslorelin acetate is an injectable gonadotropin releasing hormone super-agonist also known as an LHRH agonist. It stops the production of sex hormones. Isatoic anhydride Not Available Antithrombin III human An alpha-2-glycoprotein used to prevent thromboembolisms in patients with hereditary antithrombin III deficiency. Aclarubicin Not Annotated Candoxatrilat A dicarboxylic acid monoamide obtained by formal condensation between the amino group of cis-4-aminocyclohexanecarboxylic acid and the cyclopentanecarboxylic acid group of 1-[(2S)-2-carboxy-3-(2-methoxyethoxy)propyl]cyclopentanecarboxylic acid. A potent inhibitor of neutral endopeptidase (NEP,... Opicapone A catechol-O-methyltransferase inhibitor used as an adjunct treatment for Parkinson's Disease in adults currently receiving levodopa and a dopa decarboxylase inhibitor. Rebamipide A gastroprotective agent used in combination with other similar therapies (e.g. proton pump inhibitors) to treat gastritis and protect the gastric mucosa. Curcumin No approved therapeutic indications. Racecadotril An anti-secretory enkephalinase inhibitor useful in the treatment of diarrhea. Talazoparib A poly-ADP ribose polymerase inhibitor used to treat HER2-, BRCA mutated locally advanced or metastatic breast cancer. Pazufloxacin Pazufloxacin is under investigation in clinical trial NCT02592096 (Pazufloxacin Mesilate Ear Drops Clinical Trial Protocol). Imidapril An ACE inhibitor used in the treatment of essential hypertension. Mirodenafil Mirodenafil has been used in trials studying the treatment and supportive care of Kidney Diseases, Urologic Diseases, Renal Insufficiency, Erectile Dysfunction, and Male Erectile Dysfunction. Niraparib A poly-ADP ribose polymerase inhibitor used to treat recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer responding to platinum based chemotherapy. Saracatinib Saracatinib has been investigated for the treatment of Cancer, Osteosarcoma, Ovarian Cancer, Fallopian Tube Cancer, and Primary Peritoneal Cancer. Tilarginine Tilarginine has been investigated for the basic science, treatment, and diagnostic of Obesity, Type 2 Diabetes, Ocular Physiology, and Regional Blood Flow. Ruboxistaurin Ruboxistaurin has been investigated for the basic science of Type 2 Diabetes Mellitus and Type 1 Diabetes Mellitus. Mocetinostat Mocetinostat has been used in trials studying the treatment of Lymphoma, Urothelial Carcinoma, Relapsed and Refractory, Myelodysplastic Syndrome, and Metastatic Leiomyosarcoma, among others. Entinostat Entinostat is under investigation for the treatment and other of Volunteers, Breast Cancer, Human Volunteers, and Normal Volunteers. Entinostat has been investigated for the treatment of Non-Small Lung Cancer, Epigenetic... Acridine Carboxamide Acridine Carboxamide has been used in trials studying the treatment of Lung Cancer and Brain and Central Nervous System Tumors. Prulifloxacin A broad-spectrum fluoroquinolone antibiotic used to treat a variety of susceptible bacterial infections. Varespladib Varespladib has been investigated for the treatment and prevention of Sickle Cell Disease, Vaso-occlusive Crisis, and Acute Coronary Syndrome. Lanopepden Lanopepden has been used in trials studying the treatment of Pneumonia, Infections, Bacterial, Skin Diseases, Infectious, and Skin Infections, Bacterial. 6-O-benzylguanine 6-O-benzylguanine has been used in trials studying the treatment of HIV Infection, Adult Gliosarcoma, Adult Glioblastoma, Stage I Adult Hodgkin Lymphoma, and Stage II Adult Hodgkin Lymphoma, among others. Safingol Safingol has been used in trials studying the treatment of Unspecified Adult Solid Tumor, Protocol Specific. Delanzomib Delanzomib has been used in trials studying the treatment of Solid Tumors, Multiple Myeloma, and Lymphoma, Non-Hodgkin. Letaxaban Letaxaban has been used in trials studying the treatment and prevention of Venous Thromboembolism and Acute Coronary Syndrome. Ozagrel Ozagrel has been used in trials studying the treatment of Dry Eye Syndromes. Ulinastatin Ulinastatin has been investigated for the prevention of Cardiovascular Disease and Adverse Reaction to Drug. Orantinib Orantinib has been used in trials studying the treatment of Lung Cancer, Breast Cancer, Kidney Cancer, Gastric Cancer, and Prostate Cancer, among others. Vesnarinone Vesnarinone has been used in trials studying the treatment of HIV Infections and Sarcoma, Kaposi. Vinpocetine A synthetic derivative of a vinca alkaloid used to treat neurological symptoms of cerebrovascular disease. GSK-256066 Gsk256066 has been used in trials studying the treatment and diagnostic of SAR, Asthma, Mild Asthma, Allergic Rhinitis, and Seasonal Allergic Rhinitis, among others. S-3304 S-3304 has been used in trials studying the treatment of Lung Cancer, Solid Tumors, Non Small Cell Lung Cancer, Stage IIIB Non Small Cell Lung Cancer, and Stage IIIA Non... Exatecan Exatecan has been used in trials studying the treatment of Sarcoma, Leukemia, Lymphoma, Lung Cancer, and Liver Cancer, among others. Atamestane Atamestane has been used in trials studying the treatment of Breast Cancer, Breast Neoplasms, and Neoplasms, Hormone-Dependent. Atevirdine Atevirdine has been used in trials studying the treatment of HIV Infections. Simendan Simendan is under investigation in clinical trial NCT00527059 (Renal Effects of Levosimendan in Patients Admitted With Acute Decompensated Heart Failure). Darexaban Darexaban has been used in trials studying the prevention and basic science of Japanese, Caucasian, Thromboembolism, Pharmacodynamics, and Pharmacokinetics, among others. Cantharidin The only therapeutic use for which cantharidin is currently primarily indicated for is as an active ingredient in topical agents for treating common warts (verruca vulgaris), periungual warts, plantar warts,... Rucaparib An anti-cancer agent used to treat recurrent ovarian, fallopian tube, or peritoneal cancer. Relebactam A beta-lactamase inhibitor used to prevent hydrolysis of beta-lactam antibiotics, leading to increased effectiveness. R-306465 R306465 has been used in trials studying the treatment of Neoplasms. Nitroaspirin Nitroaspirin has been investigated for the treatment of Intermittent Claudication. Nadifloxacin A topical fluoroquinolone used in the treatment of acne and topical bacterial skin infections. Tempol Tempol has been used in trials studying the treatment of Anal Cancer. Belotecan Belotecan has been investigated for the treatment of Epithelial Ovarian Cancer. Lobucavir Lobucavir has been used in trials studying the treatment of HIV Infections and Cytomegalovirus Infections. Oltipraz Oltipraz has been used in trials studying the treatment and prevention of Lung Cancer, Liver Fibrosis, Liver Cirrhosis, and Non-alcoholic Fatty Liver Disease. Indobufen A reversible platelet aggregation inhibitor used to prevent coronary and peripheral artery occlusion. Abexinostat Abexinostat has been used in trials studying the treatment of Sarcoma, Lymphoma, Leukemia, Lymphocytic, and Hodgkin Disease, among others. It is a novel, broad-spectrum hydroxamic acid-based inhibitor of histone deacetylase... Piperine Bioperine has been used in trials studying the treatment of Multiple Myeloma and Deglutition Disorders. Nafamostat Used as an anticoagulant in patients with disseminative blood vessel coagulation, hemorrhagic lesions, and hemorrhagic tendencies. It prevents blood clot formation during extracorporeal circulation in patients undergoing continuous renal replacement... Sisomicin Sisomicin has been used in trials studying the treatment of Pyoderma. Mizoribine Mizoribine has been investigated for the treatment of Rheumatoid Arthritis. Apocynin Acetovanillone has been used in trials studying the treatment of Bronchial Asthma and Chronic Obstructive Pulmonary Disease. Salirasib Salirasib has been used in trials studying the diagnostic of Carcinoma, Non-Small-Cell Lung. Phenethyl Isothiocyanate Phenethyl Isothiocyanate has been used in trials studying the prevention and treatment of Leukemia, Lung Cancer, Tobacco Use Disorder, and Lymphoproliferative Disorders. NB-001 NB-001 has been investigated for the treatment of Recurrent Herpes Labialis. N-omega-nitro-L-arginine methyl ester L-NAME has been investigated for the treatment of Hypotension and Spinal Cord Injury. Atreleuton Atreleuton has been used in trials studying the treatment of Atherosclerosis and Coronary Artery Disease. Lometrexol Lometrexol has been used in trials studying the treatment of Lung Cancer, Drug/Agent Toxicity by Tissue/Organ, and Unspecified Adult Solid Tumor, Protocol Specific. Benserazide A medication used to treat Parkinson's disease, parkinsonism, and restless leg syndrome. Gabexate A protease inhibitor indicated in the treatment of acute pancreatitis. Sivelestat Sivelestat has been used in trials studying the treatment of Acute Lung Injury and Respiratory Distress Syndrome, Adult. Buthionine sulfoximine Buthionine sulfoximine has been used in trials studying the treatment of Neuroblastoma and Melanoma (Skin). Nolatrexed Nolatrexed is under investigation in clinical trial NCT00012324 (Nolatrexed Dihydrochloride Compared With Doxorubicin in Treating Patients With Recurrent or Unresectable Liver Cancer). Nikkomycin Z Nikkomycin Z has been used in trials studying the treatment and basic science of Coccidioidomycosis. Didox Didox has been used in trials studying the supportive care of Gastric Cancer. Mitoguazone Mitoguazone has been used in trials studying the treatment of Lymphoma, HIV Infections, and Lymphoma, Non-Hodgkin. Hypericin Hypericin is under investigation for the treatment of Cutaneous T-cell Lymphoma. MK-0873 MK-0873 has been used in trials studying the treatment of Rheumatoid Arthritis. Methanesulfonyl Fluoride Methanesulfonyl Fluoride has been used in trials studying the treatment of Safety. Liarozole Liarozole has been used in trials studying the treatment of Ichthyosis, Lamellar. Talarozole Talarozole has been investigated for the treatment of Psoriasis and Cutaneous Inflammation. Zofenopril An ACE inhibitor indicated in the treatment of hypertension. Rhein No approved indication. Daidzein Not Annotated Sitafloxacin A fluoroquinolone antibiotic indicated in the treatment of susceptible bacterial infections. Proscillaridin Proscillaridin is a cardiac glycoside that is derived from plants of the genus Scilla and in Drimia maritima (Scilla maritima). Studies suggest the potential cytotoxic and anticancer property of proscillaridin,... Delapril An ACE inhibitor indicated in the treatment of essential hypertension. Flurithromycin Not Annotated Emetine Not Annotated Linsidomine Not Annotated Metildigoxin A digitalis glycoside indicated in the treatment of acute and chronic heart failure. Tenidap Not Annotated Paraoxon Not Annotated Melagatran Not Annotated Oxolinic acid Not Annotated Proquazone Not Annotated Distigmine A cholinesterase inhibitor indicated in the treatment of neurogenic bladder dysfunction or myasthenia gravis. Camostat A serine protease indicated in Japan to treat chronic pancreatitis. Dexrabeprazole A proton pump inhibitor indicated in the treatment of gastroesophageal reflux disease and gastrointestinal ulcers. Vorozole Not Annotated Rufloxacin A fluoroquinolone antibiotic indicated in the treatment of susceptible respiratory infections and uncomplicated cystitis. Brodimoprim Not Annotated Calcium levulinate This new application of calcium is intended for use as a food fortifier, to fortify foods like sauces, condiments, beer, beverages, soft drinks, milk and milk products, soy milk and... Adefovir Not Annotated Harmaline Not Annotated Brofaromine Not Annotated Iniparib Not Annotated Coumermycin A1 Not Annotated Clinafloxacin Clinafloxacin is a fluoroquinolone antibacterial currently under research. It has been proven to present good antibiotic properties. However, its approval and release have been halted due to the presence of... Furafylline Furafylline is a derivative of methylxanthine derivative. It was developed on the context of asthma as a long-acting alternative for theophylline. ABT-341 ABT-341 is a potent and selective DPP-4 inhibitor with a structure very similar to sitagliptin (in 2D; the 3D structure is significantly different). Wortmannin Wortmannin is a steroid metabolite of Penicillium funiculosum and Talaromyces wortmannii fungi. This drug acts as a nonspecific, covalent inhibitor of phosphoinositide 3-kinase enzymes (PI3Ks). Basifungin Basifungin, also known as aureuobacidin A, is a phosphorylceramide synthase inhibitor , . SC-236 SC-236 is a potent, selective, orally active inhibitor of cyclooxygenase-2 (COX-2) that has been studied in cancer therapy , lower back pain , and inflammation , , , . NS-398 NS-398 is a COX-2 inhibitor. It was developed as part of the mechanistic study of the cyclooxygenases. Concanamycin A Concanamycin A is an H+-ATPase (vacuolar) inhibitor. Benazeprilat Not Annotated Tenofovir A nucleotide analog indicated in the treatment of HIV infections. Fosinoprilat Fosinoprilat is the active phosphinic acid metabolite of prodrug fosinopril, which is activated by esterases in vivo. It binds zinc with phosphinic acid group. Ramiprilat The active metabolite of the prodrug Ramipril. Perindoprilat The active metabolite of the prodrug Perindopril. Quinaprilat The active metabolite of the prodrug quinapril. Lithium carbonate A medication used to treat manic episodes of bipolar disorder. Magnesium levulinate A supplement to treat magnesium deficiency. Acifluorfen Acifluorfen is a protoporphyrinogen oxidase inhibitor. acetylleucyl-leucyl-norleucinal Not Available Cholesterol sulfate Component of human seminal plasma & spermatozoa. Zenarestat Investigated for use/treatment in neuropathy (diabetic). S-Ethylisothiourea S-Ethylisothiourea is a nitric oxide synthase inhibitor. Oseltamivir acid Not Available Zardaverine Not Available Isoliquiritigenin Isoliquiritigenin is a precursor to several flavonones in many plants. Brequinar Not Available Piritrexim Piritrexim has been used in trials studying the treatment of Bladder Cancer, Urethral Cancer, and Transitional Cell Cancer of the Renal Pelvis and Ureter. Clorgiline An antidepressive agent and monoamine oxidase inhibitor related to PARGYLINE. Meglutol An antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids. It acts by interfering with the enzymatic steps involved in the conversion of acetate to hydroxymethylglutaryl coenzyme A as... Pimagedine Investigated for use/treatment in diabetic kidney disease. 7-ethyl-10-hydroxycamptothecin Investigated for use/treatment in colorectal cancer. Emodin Emodin has been investigated for the treatment of Polycystic Kidney. Fasudil Fasudil has been investigated in Carotid Stenosis. Emivirine Emivirine has been used in trials studying the treatment of HIV Infections. Lapachone Lapachone has been used in trials studying the treatment of Cancer, Carcinoma, Advanced Solid Tumors, Head and Neck Neoplasms, and Carcinoma, Squamous Cell. Ebselen Ebselen has been investigated for the treatment and basic science of Meniere's Disease, Type 2 Diabetes Mellitus, and Type 1 Diabetes Mellitus. Dabigatran Dabigatran is the active form of the orally bioavailable prodrug dabigatran etexilate. Methoxy arachidonyl fluorophosphonate Methoxy arachidonyl fluorophosphonate, commonly referred as MAFP, is an irreversible active site-directed enzyme inhibitor that inhibits nearly all serine hydrolases and serine proteases. It inhibits phospholipase A2 and fatty acid... Cycloguanil Cycloguanil is the active metabolite of proguanil. Salvianolic acid A Salvianolic acid A is under investigation in clinical trial NCT03908242 (Phase I Study of Continuous Administration of Salvianolic Acid A Tablet). Antipain Antipain is a serine/cysteine protease inhibitor originally isolated from various strains of actinomycetes. Early studies investigated the potential for antipain to alter DNA damage and chromosomal aberrations in irradiated cells... Perillyl alcohol Perillyl alcohol is under investigation in clinical trial NCT02704858 (Safety and Efficacy Study in Recurrent Grade IV Glioma). Epalrestat Epalrestat is under investigation in clinical trial NCT03244358 (Evaluation of Epalrestat in Metastatic Triple-negative Breast Cancer). Cidofovir An antiviral agent used to treat Cytomegalovirus (CMV) retinitis in patients with AIDS. Famciclovir A nucleoside analog DNA polymerase inhibitor used for the treatment of recurrent cold sores and genital herpes in healthy patients and patients with HIV, and to manage herpes zoster. Caspofungin An echinocandin used to treat a variety of fungal infections. Tigecycline A glycylcycline antibiotic used to treat a number of susceptible bacterial infections. Fondaparinux An anticoagulant used to prevent venous thromboembolism, to treat deep vein thrombosis, and to improve survival following myocardial infarction. Oxaprozin An NSAID used to treat osteoarthritis, rheumatoid arthritis, and juvenile rheumatoid arthritis. Fomepizole An inhibitor of alcohol dehydrogenase used as an antidote in confirmed or suspected methanol or ethylene glycol poisoning. Sunitinib A receptor tyrosine kinase inhibitor and chemotherapeutic agent used for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). Topiroxostat Indicated for the treatment of gout and hyperurcemia in Japan. D-Eritadenine Not Available Monastrol Not Available 2,5-di-tert-butylhydroquinone Not Available Licofelone For the management of osteoarthritis. Myxothiazol Not Available Omacetaxine mepesuccinate A cephalotaxine used in the treatment of Chronic Myeloid Leukemia (CML) that is intolerant to or resistant to two or more tyrosine kinase inhibitors. Phenserine For the treatment of Alzheimer's disease (AD). Rupintrivir Investigated for use/treatment in viral infection. Ranirestat Investigated for use/treatment in neuropathy (diabetic). Pelitinib Investigated for use/treatment in colorectal cancer and lung cancer. Motesanib Investigated for use/treatment in solid tumors. Arylacenamide Investigated for use/treatment in cancer/tumors (unspecified), immunosuppressive, and prostate cancer. AV-412 Investigated for use/treatment in cancer/tumors (unspecified). Elvucitabine Investigated for use/treatment in hepatitis (viral, B) and HIV infection. Indisulam Investigated for use/treatment in lung cancer. Human C1-esterase inhibitor A C1 inhibitor used to prevent angioedema attacks associated with hereditary angioedema. Lonafarnib A potent farnesyl transferase inhibitor used to reduce mortality associated with Hutchinson-Gilford progeria syndrome (HGPS) and other progeroid laminopathies. Cetilistat Investigated for use/treatment in obesity. Mafenide An antimicrobial topical agent indicated for use as an adjunctive treatment to control bacterial infection when used under moist dressings over meshed autografts on excised burn wounds. Capravirine Investigated for use/treatment in acquired immune deficiency syndrome (AIDS) and aids-related infections and HIV infection. Vemurafenib A kinase inhibitor used to treat patients with Erdheim-Chester Disease who have the BRAF V600 mutation, and melanoma in patients who have the BRAF V600E mutation. Afatinib An antineoplastic agent used for the treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC) with non-resistant EGFR mutations or resistance to platinum-based chemotherapy. Finafloxacin Finafloxacin is indicated for the treatment of acute otitis externa (AOE) with or without an otowick, caused by susceptible strains of Pseudomonas aeruginosa and Staphylococcus aureus in patients age 1... Desirudin Indicated as prophylaxis of deep vein thrombosis for patients undergoing hip replacement surgery. Asunaprevir An NS3 protease inhibitor used to treat hepatitis C genotype 1b. Ilorasertib Ilorasertib has been used in trials studying the treatment of Myelodysplasia, Solid Neoplasm, Advanced Cancers, Advanced Solid Tumors, and Acute Myelogenous Leukemia, among others. Peficitinib Peficitinib has been used in trials studying the treatment and basic science of Psoriasis, Pharmacodynamics, Drug Interactions, Colitis, Ulcerative, and RHEUMATOID ARTHRITIS, among others. MK-1775 MK-1775 has been used in trials studying the treatment of LYMPHOMA, Neoplasms, Ovarian Cancer, Tongue Carcinoma, and Adult Glioblastoma, among others. Pevonedistat Pevonedistat has been used in trials studying the treatment of Lymphoma, Solid Tumors, Multiple Myeloma, Hodgkin Lymphoma, and Metastatic Melanoma, among others. Momelotinib Momelotinib has been used in trials studying the treatment of Polycythemia Vera, Primary Myelofibrosis, Post-Polycythemia Vera, Essential Thrombocythemia, and Primary Myelofibrosis (PMF), among others. PF-04991532 PF-04991532 has been used in trials studying the basic science of Diabetes Mellitus, Type 2 Diabetes Mellitus, Diabetes Mellitus, Type 2, and Glucose Metabolism Disorders. Tosedostat Tosedostat has been used in trials studying the treatment and supportive care of AML, Leukemia, Pancreas Cancer, Multiple Myeloma, and Pancreatic Cancer, among others. Tosedostat is an inhibitor of the... GSK-2636771 GSK2636771 has been used in trials studying the treatment of CANCER, LYMPHOMA, Solid Neoplasm, Recurrent Solid Neoplasm, and Advanced Malignant Neoplasm, among others. Pritelivir Pritelivir has been used in trials studying the prevention of HSV-2 and Genital Herpes. Bafetinib Bafetinib has been used in trials studying the treatment of Adult Gliosarcoma, Adult Mixed Glioma, Adult Glioblastoma, Chronic Myeloid Leukemia, and Acute Lymphocytic Leukemia, among others. Gedatolisib Gedatolisib has been used in trials studying the basic science and treatment of Neoplasm, Ovary Cancer, Breast Cancer, Advanced Cancer, and Endometrial Cancer, among others. Flumatinib Flumatinib has been used in trials studying the treatment of Myelogenous Leukemia, Chronic. Bempedoic acid A drug used in conjunction with lifestyle modification and/or other agents for the treatment of refractory hypercholesterolemia. Tesevatinib Tesevatinib has been used in trials studying the treatment of Cancer, Stomach Cancer, Brain Metastases, Esophageal Cancer, and Leptomeningeal Metastases, among others. Tesevatinib is a potent inhibitor of multiple RTKs... Entrectinib Entrectinib is indicated for the treatment of metastatic ROS1-positive non-small cell lung cancer in adults. Entrectinib is also indicated in adults and children over 12 years old for the treatment... Naquotinib Naquotinib has been used in trials studying the treatment of Solid Tumors, Non-small Cell Lung Cancer, Non-Small-Cell Lung Cancer (NSCLC), Epidermal Growth Factor Receptor Mutations, and Epidermal Growth Factor Receptor... Vaborbactam A beta lactamase inhibitor used to treat complicated urinary tract infections. Rigosertib Rigosertib has been used in trials studying the treatment and basic science of MDS, RAEB, Cancer, Hepatoma, and Neoplasms, among others. Obatoclax Obatoclax has been used in trials studying the treatment of AML, Leukemia, Myelofibrosis, Hodgkin's Lymphoma, and Mantle-Cell Lymphoma, among others. Betrixaban A Factor Xa inhibitor used for prophylaxis of venous thromboembolism in hospitalized patients. Ricolinostat Ricolinostat is under investigation for the treatment of Breast Carcinoma and Metastatic Breast Cancer. Zamicastat Zamicastat has been used in trials studying the treatment of Hypertension and Chronic Heart Failure. Galeterone Galeterone has been used in trials studying the treatment of Prostate Cancer. Anagliptin Anagliptin is under investigation for the treatment of LDL Cholesterol, Coronary Disease, Diabetes Mellitus, Glycosylated Hemoglobin, and Dipeptidyl-Peptidase 4 Inhibitors. Dexelvucitabine Dexelvucitabine has been used in trials studying the treatment of HIV Infections and Human Immunodeficiency Virus. Acotiamide Acotiamide has been used in trials studying the treatment of Dyspepsia and Functional Dyspepsia. WNT-974 WNT974 has been used in trials studying the treatment of Metastatic Colorectal Cancer and Squamous Cell Carcinoma, Head And Neck. Rimacalib Rimacalib has been used in trials studying the treatment of Rheumatoid Arthritis (RA). Bindarit Bindarit has been used in trials studying the prevention and treatment of Coronary Restenosis and Diabetic Nephropathy. Rebastinib Rebastinib has been used in trials studying the treatment of Chronic Myeloid Leukemia. It is an inhibitor of Tie2 tyrosine kinase receptor and an antineoplastic agent. LCB01-0371 Lcb01 0371 is under investigation in clinical trial NCT01554995 (A Clinical Study, Randomized, Double-blind, Placebo-controlled, Single Dose Study). AZD-0424 AZD0424 has been used in trials studying the treatment of Advanced Solid Tumours. X-396 X-396 has been used in trials studying the treatment of Advanced Solid Tumors and Non-small Cell Lung Cancer. Reposal Reposal is a barbiturate derivative invented in the 1960s in Denmark that has sedative, hypnotic and anticonvulsant properties. It was used primarily in the treatment of insomnia. Baloxavir marboxil A polymerase acidic endonuclease inhibitor used to treat uncomplicated influenza. Ivosidenib An isocitrate dehydrogenase-1 inhibitor used to treat acute myeloid leukemia with a susceptible mutation. CPI-1205 Potent and selective histone methyltransferase EZH2 inhibitor. Rivoceranib Rivoceranib is under investigation in clinical trial NCT02726854 (Apatinib as Second-line Treatment of Advanced Pancreatic Cancer). Ensartinib Ensartinib is under investigation in clinical trial NCT03420508 (Treating Patients With Melanoma and ALK Alterations With Ensartinib). Selitrectinib Selitrectinib is under investigation in clinical trial NCT03215511 (Phase 1/2 Study of LOXO-195 in Patients With Previously Treated NTRK Fusion Cancers). Imetelstat Imetelstat is under investigation in clinical trial NCT01916187 (Imetelstat Given Intravenously Alone and With Standard 13-Cis-Retinoic Acid in Children With Neuroblastoma). Serabelisib Serabelisib is under investigation in clinical trial NCT02625259 (A Study to Evaluate the Relative Bioavailability, Effect of Food, and Gastric Potential Hydrogen (pH) Modification on the Pharmacokinetics of TAK-117 (MLN1117)... Etirinotecan pegol Etirinotecan pegol is under investigation in clinical trial NCT01663012 (Phase II NKTR-102 In Bevacizumab-Resistant High Grade Glioma). Linrodostat Linrodostat is under investigation in clinical trial NCT03247283 (Pharmacokinetics and Metabolism Study in Healthy Male Participants). PF-06700841 PF-06700841 is under investigation in clinical trial NCT03236493 (Safety and Pharmacokinetic Study of PF-06700841 in Japanese Healthy Volunteers). Zanubrutinib A kinase inhibitor used to treat mantle cell lymphoma, a type of B-cell non-Hodgkin lymphoma, in adults who previously received therapy. Upadacitinib An oral Janus kinase (JAK)1-selective inhibitor used in the treatment of moderate to severe rheumatoid arthritis, active psoriatic arthritis, ankylosing spondylitis, and severe atopic dermatitis, including in patients who did not respond well to other therapies. Voruciclib Voruciclib is under investigation in clinical trial NCT03547115 (A Phase 1 Study of Voruciclib in Subjects With B-Cell Malignancies or AML). GDC-0084 GDC-0084 is under investigation in clinical trial NCT03696355 (Study of GDC-0084 in Pediatric Patients With Newly Diagnosed Diffuse Intrinsic Pontine Glioma or Diffuse Midline Gliomas). KRN-5500 KRN-5500 is under investigation in clinical trial NCT00002923 (KRN5500 in Treating Patients With Metastatic Solid Tumors). Avidin Avidin is under investigation in clinical trial NCT00345618 (Clinical Study Assessing Idrabiotaparinux Sodium Injections Once-weekly in Pulmonary Embolism Therapeutic Approach). CB-1158 CB-1158 is under investigation in clinical trial NCT03910530 (A Study of INCMGA00012, INCB001158, and the Combination in Japanese Participants With Advanced Solid Tumors). Posiphen Posiphen is under investigation in clinical trial NCT02925650 (Safety, Tolerability, PK and PD of Posiphen® in Subjects With Early Alzheimer's Disease). Abivertinib Abivertinib is a tyrosine kinase inhibitor targeted against mutant forms of both human epidermal growth factor receptor (EGFR) and Bruton's tyrosine kinase (BTK). It has been investigated for use in... Cilazaprilat Not Annotated p-Hydroxymercuribenzoic acid Not Available 2-[3-(5-Mercapto-[1,3,4]thiadiazol-2-yl)-ureido]-N-methyl-3-phenyl-propionamide Not Available 2-[3-(5-Mercapto-[1,3,4]thiadiazol-2yl)-ureido]-N-methyl-3-pentafluorophenyl-propionamide Not Available 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide Not Available 2-deoxy-2,3-dehydro-N-acetylneuraminic acid Not Available Thiocitrulline Not Available Echinomycin Echinomycin is a cytotoxic polypeptide quinoxaline antibiotic isolated from Streptomyces echinatus that binds to DNA and inhibits RNA synthesis. Ursolic acid Not Annotated N(G)-Iminoethylornithine Not Available R-82913 Not Available H-89 Not Available Zopolrestat Not Available CGS-27023 Not Available Bisindolylmaleimide VIII Not Available CP-320626 Not Available Trichostatin A Not Available GW-813893 Not Available Y-27632 Y-27632 is an inhibitor of Rho-associated protein kinase. It inhibits calcium sensitization to affect smooth muscle relaxation. Bisindolylmaleimide I Not Available 5-Benzylacyclouridine Not Available Harmine Not Available Dichlororibofuranosylbenzimidazole Not Available Dorsomorphin Not Available Adenosine 5'-methylenediphosphate Not Available t-Butylhydroquinone Not Available Islatravir Islatravir is under investigation in clinical trial NCT04233216 (Doravirine/islatravir (DOR/ISL) in Heavily Treatment-experienced (HTE) Participants for Human Immunodeficiency Virus Type 1 (HIV-1) Infection (MK-8591A-019)). Methyldopa A centrally-acting alpha-2 adrenergic agonist used to manage hypertension alone or in combination with hydrochlorothiazide, and to treat hypertensive crises. Baloxavir Baloxavir is under investigation in clinical trial NCT04327791 (Combination Therapy With Baloxavir and Oseltamavir 1 for Hospitalized Patients With Influenza (The COMBO Trial 1)). (Rp)-cAMPS Not Available Vigabatrin An irreversible GABA transaminase inhibitor used as an adjunct therapy to treat refractory complex partial seizures in patients ≥2 years unresponsive to alternatives. May also be used as monotherapy to treat infantile spasms in infants 1 month to 2 years. Zinc protoporphyrin Not Available Carbaryl A medication used in shampoo to remove lice. Garlic oil Not Annotated FF-10101-01 FF-10101-01 is under investigation in clinical trial NCT03194685 (Study of FF-10101-01 in Patients With Relapsed or Refractory Acute Myeloid Leukemia). Aclimostat Aclimostat is under investigation in clinical trial NCT03254368 (Study to Assess the Effects and Safety of ZGN-1061 in Overweight and Obese Participants With Type 2 Diabetes). Acrizanib Acrizanib is under investigation in clinical trial NCT02355028 (LHA510 Proof-of-concept Study as a Maintenance Therapy for Patients With Wet Age-related Macular Degeneration). Baicalein Baicalein is under investigation in clinical trial NCT03830684 (A Randomized, Double-blind, Placebo-controlled, Multicenter and Phase ⅡA Clinical Trial for the Effectiveness and Safety of Baicalein Tablets in the Treatment of... HIV Integrase Inhibitor HIV Integrase Inhibitor is under investigation in clinical trial NCT00397566 (A Multiple Ascending Dose Study of BMS-707035 in HIV-1 Infected Subjects). Firsocostat Firsocostat is under investigation in clinical trial NCT02781584 (Safety, Tolerability, and Efficacy of Selonsertib, Firsocostat, and Cilofexor in Adults With Nonalcoholic Steatohepatitis (NASH)). Nafithromycin Nafithromycin is under investigation in clinical trial NCT02903836 (Phase II Study of Oral Nafithromycin in CABP). Nemiralisib Nemiralisib is under investigation in clinical trial NCT03345407 (Dose Finding Study of Nemiralisib (GSK2269557) in Subjects With an Acute Moderate or Severe Exacerbation of Chronic Obstructive Pulmonary Disease (COPD)). Osoresnontrine Osoresnontrine is under investigation in clinical trial NCT02281773 (A Study to Investigate the Efficacy, Safety and Tolerability of Four Different Doses of BI 409306 Compared to Placebo Given for 12... Racemetyrosine Racemetyrosine is under investigation in clinical trial NCT03512756 (A Randomized Phase 2/3 Multi-center Study of SM-88 in Patients With Metastatic Pancreatic Cancer). Veliflapon Veliflapon is under investigation in clinical trial NCT00353067 (Veliflapon (Dg-031)to Prevent Heart Attacks or Stroke in Patients With a History of Heart Attack or Unstable Angina). Tin protoporphyrin IX Not Available Deucravacitinib Deucravacitinib is under investigation in clinical trial NCT04772079 (A Study to Evaluate the Drug Levels, Efficacy and Safety of BMS-986165 in Adolescent Participants With Moderate to Severe Plaque Psoriasis). Telaprevir An NS3/4A viral protease inhibitor used in combination with other antivirals for the curative treatment of chronic Hepatitis C Virus infections. Boceprevir A hepatitis C virus NS3/4A protease inhibitor used in combination with other medications to treat chronic hepatitis C genotype 1 infection. Boceprevir is not indicated as monotherapy. Faldaprevir Faldaprevir has been investigated for the treatment of Chronic Hepatitis C. Conestat alfa A recombinant C1INH used for the treatment of acute attacks of hereditary angioedema (HAE) due to C1 esterase inhibitor deficiency in adults. Tipranavir A protease inhibitor used to treat HIV-1 resistant to more than 1 protease inhibitor. Epicaptopril Not Available Carbomer Not Annotated Nirmatrelvir An oral protease inhibitor with emergency use authorization for the treatment of mild-to-moderate COVID-19. MK-886 MK-886 is an experimental inhibitor of leukotriene synthesis.
- Drugs & Drug Targets