Dopamine And Norepinephrine Reuptake Inhibitors

Name
Dopamine And Norepinephrine Reuptake Inhibitors
Accession Number
DBCAT005675
Description

Drugs that block specific transporter proteins, increasing the amount of active norepinephrine and dopamine neurotransmitters in the brain.

Drugs
DrugDrug Description
SolriamfetolSolriamfetol is indicated for treatment of daytime sleepiness associated with obstructive sleep apnea and narcolepsy, but is not a treatment for the underlying airway obstruction in apnea patients[FDA Label][A176534,A176744].
BupropionA norepinephrine and dopamine reuptake inhibitor used in the treatment of major depressive disorder (MDD), seasonal affective disorder (SAD), and as an aid to smoking cessation.
Drugs & Drug Targets
DrugTargetType
SolriamfetolSolute carrier family 22 member 2transporter
SolriamfetolSolute carrier family 22 member 4transporter
SolriamfetolSolute carrier family 22 member 5transporter
SolriamfetolSodium-dependent dopamine transportertarget
SolriamfetolSodium-dependent noradrenaline transportertarget
BupropionSodium-dependent dopamine transportertarget
BupropionSodium-dependent noradrenaline transportertarget
BupropionCytochrome P450 2B6enzyme
BupropionCytochrome P450 2D6enzyme
BupropionAlpha-1-acid glycoprotein 1carrier
BupropionNeuronal acetylcholine receptor subunit alpha-3target
BupropionCytochrome P450 2C9enzyme
BupropionCytochrome P450 2E1enzyme
BupropionSolute carrier family 22 member 2transporter
Bupropion5-hydroxytryptamine receptor 3Atarget