Solriamfetol

DB14754ApprovedInvestigationalSmall moleculeDopamine And Norepinephrine Reuptake InhibitorsWakefulness-Promoting Agents

Solriamfetol marketed under the brand name Sunosi by Jazz Pharmaceuticals in the United States is a dopamine and norepinephrine reuptake inhibitor (DNRI) indicated in treating daytime sleepiness associated with narcolepsy... Solriamfetol was given FDA approval in 2019.

Chemical structure of Solriamfetol
Mechanism
Curator reviewed · 1 reference
Primary indication
Solriamfetol is indicated for treatment of daytime sleepiness associated with obstructive sleep apnea and narcolepsy, but is not a treatment for the underlying airway obstruction in apnea patients.Curator reviewed · 2 structured indications
Formula / weight
C10H14N2O2 · 194.234 g/mol (avg)
First approval
Canada, 2022 · United States, 2019 · European Union, 2020
Code names
JZP-110 · R-228060 · SKL-N-05 · YKP-10A
Brand names
  • Sunosi

Resolves to

Compound
UNII939U7C91AICAS178429-62-4ChEMBLCHEMBL4297620ChEBI757090PubChem10130337
Clinical / RWD
RxNorm2121751ATCN06BA14
Structure
InChIKeyUCTRAOBQFUDCSR-SECBINFHSA-NSMILESN[C@@H](COC(N)=O)CC1=CC=CC=C1
Targets
Q01959SLC6A3P23975SLC6A2
Transporters
O15244SLC22A2Q9H015SLC22A4O76082SLC22A5Q96FL8SLC47A1

What you can answer from here — as of September 23, 2026

2Protein targetsEach mapped to UniProt, with action and pharmacological action
Listed above
4TransportersSubstrate / inhibitor direction, not just membership
Listed above
1,653Drug interactionsStructured to mechanism, not free text
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30Clinical trialsPhase, status and sponsor resolved per trial
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2Structured indicationsCondition, population, route and combination as fields, not prose
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1ContraindicationEach with its own population and attribute set
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26Marketed productsAcross 4 countries and 5 labellers
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1ATC codeIncluding every combination product, plus 28 drug categories
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15+ReferencesStructured and connected to the statements they support
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Which drugs share a target with Solriamfetol, and which of those have an active Phase 3 trial?

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