Mitogen-activated protein kinase (MEK) inhibitors

Name
Mitogen-activated protein kinase (MEK) inhibitors
Accession Number
DBCAT005740
Description

Not Available

ATC Classification
Drugs
DrugDrug Description
CobimetinibAn antineoplastic agent and selective inhibitor of the mitogen-activated extracellular kinase (MEK) pathway used to treat unresectable or metastatic melanoma.
TrametinibA kinase inhibitor used alone or in combination with dabrafenib to treat patients with cancers with specific BRAF mutations, such as melanoma and non-small cell lung cancer.
SelumetinibA MEK 1/2 inhibitor used in pediatric patients to treat neurofibromatosis type 1 (NF1) accompanied by symptomatic, inoperable plexiform neurofibromas (PN).
BinimetinibA medication used to treat metastatic melanoma with specific mutations.
Drugs & Drug Targets
DrugTargetType
CobimetinibDual specificity mitogen-activated protein kinase kinase 1target
CobimetinibCytochrome P450 3A4enzyme
CobimetinibSolute carrier organic anion transporter family member 1B1transporter
CobimetinibSolute carrier organic anion transporter family member 1B3transporter
CobimetinibATP-binding cassette sub-family G member 2transporter
CobimetinibP-glycoprotein 1transporter
CobimetinibUDP-glucuronosyltransferase 2B7enzyme
CobimetinibCytochrome P450 2D6enzyme
CobimetinibCytochrome P450 3A5enzyme
CobimetinibAlpha-1-acid glycoprotein 1carrier
TrametinibCytochrome P450 2C8enzyme
TrametinibCytochrome P450 3A4enzyme
TrametinibDual specificity mitogen-activated protein kinase kinase 1target
TrametinibDual specificity mitogen-activated protein kinase kinase 2target
SelumetinibDual specificity mitogen-activated protein kinase kinase 1target
SelumetinibDual specificity mitogen-activated protein kinase kinase 2target
SelumetinibSerum albumincarrier
Selumetinibalpha1-acid glycoproteincarrier
SelumetinibP-glycoprotein 1transporter
SelumetinibATP-binding cassette sub-family G member 2transporter
SelumetinibCytochrome P450 2C19enzyme
SelumetinibUDP-glucuronosyltransferase 1-1enzyme
SelumetinibCytochrome P450 2C9enzyme
SelumetinibCytochrome P450 3A4enzyme
SelumetinibCytochrome P450 1A2enzyme
SelumetinibCytochrome P450 2C8enzyme
SelumetinibUDP-glucuronosyltransferase 1-3enzyme
SelumetinibCytochrome P450 2E1enzyme
SelumetinibCytochrome P450 3A5enzyme
BinimetinibUDP-glucuronosyltransferase 1-1enzyme
BinimetinibCytochrome P450 1A2enzyme
BinimetinibCytochrome P450 2C19enzyme
BinimetinibDual specificity mitogen-activated protein kinase kinase 2target
BinimetinibSerum albumincarrier
BinimetinibDual specificity mitogen-activated protein kinase kinase 1target
BinimetinibATP-binding cassette sub-family G member 2transporter
BinimetinibP-glycoprotein 1transporter